TY  - JOUR
UR  - http://doi.org/10.1016/j.foodchem.2024.138516
VL  - 444
N2  - In this study, the phytochemical profile of fifty olive leaves (OL) extracts from Spain, Italy, Greece, Portugal, and Morocco was characterized and their anti-cholinergic, anti-inflammatory, and antioxidant activities were evaluated. Luteolin-7-O-glucoside, isoharmnentin, and apigenin were involved in the acetylcholinesterase (AChE) inhibitory activity, while oleuropein and hydroxytyrosol showed noteworthy potential. Secoiridoids contributed to the cyclooxygenase-2 inhibitory activity and antioxidant capacity. Compounds such as oleuropein, ligstroside and luteolin-7-O-glucoside, may exert an important role in the ferric reducing antioxidant capacity. It should be also highlighted the role of hydroxytyrosol, hydroxycoumarins, and verbascoside concerning the antioxidant activity. This research provides valuable insights and confirms that specific compounds within OL extracts contribute to distinct anti-cholinergic, anti-inflammatory, and anti-oxidative effects.
Y1  - 2024/01//
KW  - Cholinergic; AChE; COX; Inflammation; Iron; Oxidative stress; Olive; Leaves
AV  - public
A1  - Romero-Márquez, Jose M.
A1  - Navarro-Hortal, María D.
A1  - Forbes-Hernández, Tamara Y.
A1  - Varela-López, Alfonso
A1  - Puentes, Juan G.
A1  - Sánchez-González, Cristina
A1  - Sumalla Cano, Sandra
A1  - Battino, Maurizio
A1  - García-Ruiz, Roberto
A1  - Sánchez, Sebastián
A1  - Quiles, José L.
TI  - Effect of olive leaf phytochemicals on the anti-acetylcholinesterase, anti-cyclooxygenase-2 and ferric reducing antioxidant capacity
SN  - 03088146
JF  - Food Chemistry
ID  - uninimx10843
ER  -