eprintid: 10843 rev_number: 9 eprint_status: archive userid: 2 dir: disk0/00/01/08/43 datestamp: 2024-02-12 23:30:28 lastmod: 2024-02-12 23:30:28 status_changed: 2024-02-12 23:30:28 type: article metadata_visibility: show creators_name: Romero-Márquez, Jose M. creators_name: Navarro-Hortal, María D. creators_name: Forbes-Hernández, Tamara Y. creators_name: Varela-López, Alfonso creators_name: Puentes, Juan G. creators_name: Sánchez-González, Cristina creators_name: Sumalla Cano, Sandra creators_name: Battino, Maurizio creators_name: García-Ruiz, Roberto creators_name: Sánchez, Sebastián creators_name: Quiles, José L. creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: sandra.sumalla@uneatlantico.es creators_id: maurizio.battino@uneatlantico.es creators_id: creators_id: creators_id: jose.quiles@uneatlantico.es title: Effect of olive leaf phytochemicals on the anti-acetylcholinesterase, anti-cyclooxygenase-2 and ferric reducing antioxidant capacity ispublished: pub subjects: uneat_sn divisions: uneatlantico_produccion_cientifica divisions: uninimx_produccion_cientifica full_text_status: public keywords: Cholinergic; AChE; COX; Inflammation; Iron; Oxidative stress; Olive; Leaves abstract: In this study, the phytochemical profile of fifty olive leaves (OL) extracts from Spain, Italy, Greece, Portugal, and Morocco was characterized and their anti-cholinergic, anti-inflammatory, and antioxidant activities were evaluated. Luteolin-7-O-glucoside, isoharmnentin, and apigenin were involved in the acetylcholinesterase (AChE) inhibitory activity, while oleuropein and hydroxytyrosol showed noteworthy potential. Secoiridoids contributed to the cyclooxygenase-2 inhibitory activity and antioxidant capacity. Compounds such as oleuropein, ligstroside and luteolin-7-O-glucoside, may exert an important role in the ferric reducing antioxidant capacity. It should be also highlighted the role of hydroxytyrosol, hydroxycoumarins, and verbascoside concerning the antioxidant activity. This research provides valuable insights and confirms that specific compounds within OL extracts contribute to distinct anti-cholinergic, anti-inflammatory, and anti-oxidative effects. date: 2024-01 publication: Food Chemistry volume: 444 pagerange: 138516 id_number: doi:10.1016/j.foodchem.2024.138516 refereed: TRUE issn: 03088146 official_url: http://doi.org/10.1016/j.foodchem.2024.138516 access: close language: en citation: Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica Universidad Internacional Iberoamericana México > Investigación > Producción Científica Cerrado Inglés In this study, the phytochemical profile of fifty olive leaves (OL) extracts from Spain, Italy, Greece, Portugal, and Morocco was characterized and their anti-cholinergic, anti-inflammatory, and antioxidant activities were evaluated. Luteolin-7-O-glucoside, isoharmnentin, and apigenin were involved in the acetylcholinesterase (AChE) inhibitory activity, while oleuropein and hydroxytyrosol showed noteworthy potential. Secoiridoids contributed to the cyclooxygenase-2 inhibitory activity and antioxidant capacity. Compounds such as oleuropein, ligstroside and luteolin-7-O-glucoside, may exert an important role in the ferric reducing antioxidant capacity. It should be also highlighted the role of hydroxytyrosol, hydroxycoumarins, and verbascoside concerning the antioxidant activity. This research provides valuable insights and confirms that specific compounds within OL extracts contribute to distinct anti-cholinergic, anti-inflammatory, and anti-oxidative effects. metadata Romero-Márquez, Jose M.; Navarro-Hortal, María D.; Forbes-Hernández, Tamara Y.; Varela-López, Alfonso; Puentes, Juan G.; Sánchez-González, Cristina; Sumalla Cano, Sandra; Battino, Maurizio; García-Ruiz, Roberto; Sánchez, Sebastián y Quiles, José L. mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, sandra.sumalla@uneatlantico.es, maurizio.battino@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, jose.quiles@uneatlantico.es (2024) Effect of olive leaf phytochemicals on the anti-acetylcholinesterase, anti-cyclooxygenase-2 and ferric reducing antioxidant capacity. Food Chemistry, 444. p. 138516. ISSN 03088146 document_url: http://repositorio.unini.edu.mx/id/eprint/10843/1/1-s2.0-S030881462400164X-main.pdf