TY  - JOUR
IS  - 2
Y1  - 2024/02//
KW  - isoflavones; polyphenols; phytoestrogens; equol; vascular; gut microbiota
VL  - 17
AV  - public
JF  - Pharmaceuticals
ID  - uninimx10845
UR  - http://doi.org/10.3390/ph17020236
SN  - 1424-8247
A1  - Laudani, Samuele
A1  - Godos, Justyna
A1  - Romano, Giovanni Luca
A1  - Gozzo, Lucia
A1  - Di Domenico, Federica Martina
A1  - Dominguez Azpíroz, Irma
A1  - Martínez Díaz, Raquel
A1  - Giampieri, Francesca
A1  - Quiles, José L.
A1  - Battino, Maurizio
A1  - Drago, Filippo
A1  - Galvano, Fabio
A1  - Grosso, Giuseppe
TI  - Isoflavones Effects on Vascular and Endothelial Outcomes: How Is the Gut Microbiota Involved?
N2  - Isoflavones are a group of (poly)phenols, also defined as phytoestrogens, with chemical structures comparable with estrogen, that exert weak estrogenic effects. These phytochemical compounds have been targeted for their proven antioxidant and protective effects. Recognizing the increasing prevalence of cardiovascular diseases (CVD), there is a growing interest in understanding the potential cardiovascular benefits associated with these phytochemical compounds. Gut microbiota may play a key role in mediating the effects of isoflavones on vascular and endothelial functions, as it is directly implicated in isoflavones metabolism. The findings from randomized clinical trials indicate that isoflavone supplementation may exert putative effects on vascular biomarkers among healthy individuals, but not among patients affected by cardiometabolic disorders. These results might be explained by the enzymatic transformation to which isoflavones are subjected by the gut microbiota, suggesting that a diverse composition of the microbiota may determine the diverse bioavailability of these compounds. Specifically, the conversion of isoflavones in equol?a microbiota-derived metabolite?seems to differ between individuals. Further studies are needed to clarify the intricate molecular mechanisms behind these contrasting results.
ER  -