TY  - JOUR
KW  - Skin damage
KW  -  UVA-radiation
KW  -  ROS
KW  -  Apoptosis
KW  -  Mitochondria functionality
KW  -  Antioxidant defense
KW  -  Inflammatory status
KW  -  Strawberry polyphenols; Cosmetic formulation.
Y1  - 2017///
IS  - 6
SN  - 2072-6643
UR  - http://doi.org/10.3390/nu9060605
ID  - uninimx141
TI  - Strawberry-Based Cosmetic Formulations Protect Human Dermal Fibroblasts against UVA-Induced Damage
N2  - Extreme exposure of skin to Ultraviolet A (UVA)-radiation may induce a dysregulated production of reactive oxygen species (ROS) which can interact with cellular biomolecules leading to oxidative stress, inflammation, DNA damage, and alteration of cellular molecular pathways, responsible for skin photoaging, hyperplasia, erythema, and cancer. For these reasons, the use of dietary natural bioactive compounds with remarkable antioxidant activity could be a strategic tool to counteract these UVA-radiation-caused deleterious effects. Thus, the purpose of the present work was to test the efficacy of strawberry (50 ?g/mL)-based formulations supplemented with Coenzyme Q10 (100 ?g/mL) and sun protection factor 10 in human dermal fibroblasts irradiated with UVA-radiation. The apoptosis rate, the amount of intracellular reactive oxygen species (ROS) production, the expression of proteins involved in antioxidant and inflammatory response, and mitochondrial functionality were evaluated. The results showed that the synergic topical use of strawberry and Coenzyme Q10 provided a significant (p < 0.05) photoprotective effect, reducing cell death and ROS, increasing antioxidant defense, lowering inflammatory markers, and improving mitochondrial functionality. The obtained results suggest the use of strawberry-based formulations as an innovative, natural, and useful tool for the prevention of UVA exposure-induced skin diseases in order to decrease or substitute the amount of synthetic sunscreen agents.
A1  - Gasparrini, Massimiliano
A1  - Forbes-Hernandez, Tamara Y.
A1  - Afrin, Sadia
A1  - Reboredo-Rodriguez, Patricia
A1  - Cianciosi, Danila
A1  - Mezzetti, Bruno
A1  - Quiles, José L.
A1  - Bompadre, Stefano
A1  - Battino, Maurizio
A1  - Giampieri, Francesca
JF  - Nutrients
AV  - public
VL  - 9
ER  -