eprintid: 16759 rev_number: 9 eprint_status: archive userid: 2 dir: disk0/00/01/67/59 datestamp: 2025-02-20 23:30:09 lastmod: 2025-02-20 23:30:10 status_changed: 2025-02-20 23:30:09 type: article metadata_visibility: show creators_name: Godos, Justyna creators_name: Currenti, Walter creators_name: Ferri, Raffaele creators_name: Lanza, Giuseppe creators_name: Caraci, Filippo creators_name: Frias-Toral, Evelyn creators_name: Guglielmetti, Monica creators_name: Ferraris, Cinzia creators_name: Lipari, Vivian creators_name: Carvajal Altamiranda, Stefanía creators_name: Galvano, Fabio creators_name: Castellano, Sabrina creators_name: Grosso, Giuseppe creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: vivian.lipari@uneatlantico.es creators_id: stefania.carvajal@uneatlantico.es creators_id: creators_id: creators_id: title: Chronotype and Cancer: Emerging Relation Between Chrononutrition and Oncology from Human Studies ispublished: pub subjects: uneat_bm subjects: uneat_sn divisions: uneatlantico_produccion_cientifica divisions: unincol_produccion_cientifica divisions: uninimx_produccion_cientifica divisions: unic_produccion_cientifica divisions: uniromana_produccion_cientifica full_text_status: public note: chronotype; sleep; time-restricted eating; circadian rhythm; metabolic dysregulation; gut microbiota; cancer abstract: Fasting–feeding timing is a crucial pattern implicated in the regulation of daily circadian rhythms. The interplay between sleep and meal timing underscores the importance of maintaining circadian alignment in order to avoid creating a metabolic environment conducive to carcinogenesis following the molecular and systemic disruption of metabolic performance and immune function. The chronicity of such a condition may support the initiation and progression of cancer through a variety of mechanisms, including increased oxidative stress, immune suppression, and the activation of proliferative signaling pathways. This review aims to summarize current evidence from human studies and provide an overview of the potential mechanisms underscoring the role of chrononutrition (including time-restricted eating) on cancer risk. Current evidence shows that the morning chronotype, suggesting an alignment between physiological circadian rhythms and eating timing, is associated with a lower risk of cancer. Also, early time-restricted eating and prolonged nighttime fasting were also associated with a lower risk of cancer. The current evidence suggests that the chronotype influences cancer risk through cell cycle regulation, the modulation of metabolic pathways and inflammation, and gut microbiota fluctuations. In conclusion, although there are no clear guidelines on this matter, emerging evidence supports the hypothesis that the role of time-related eating (i.e., time/calorie-restricted feeding and intermittent/periodic fasting) could potentially lead to a reduced risk of cancer. date: 2025-01 publication: Nutrients volume: 17 number: 3 pagerange: 529 id_number: doi:10.3390/nu17030529 refereed: TRUE issn: 2072-6643 official_url: http://doi.org/10.3390/nu17030529 access: open language: en citation: Artículo Materias > Biomedicina <http://repositorio.unini.edu.mx/view/subjects/uneat=5Fbm.html> Materias > Alimentación <http://repositorio.unini.edu.mx/view/subjects/uneat=5Fsn.html> Universidad Europea del Atlántico > Investigación > Producción Científica <http://repositorio.unini.edu.mx/view/divisions/uneatlantico=5Fproduccion=5Fcientifica.html> Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica <http://repositorio.unini.edu.mx/view/divisions/unincol=5Fproduccion=5Fcientifica.html> Universidad Internacional Iberoamericana México > Investigación > Artículos y libros <http://repositorio.unini.edu.mx/view/divisions/uninimx=5Fproduccion=5Fcientifica.html> Universidad Internacional do Cuanza > Investigación > Producción Científica <http://repositorio.unini.edu.mx/view/divisions/unic=5Fproduccion=5Fcientifica.html> Universidad de La Romana > Investigación > Producción Científica <http://repositorio.unini.edu.mx/view/divisions/uniromana=5Fproduccion=5Fcientifica.html> Abierto Inglés Fasting–feeding timing is a crucial pattern implicated in the regulation of daily circadian rhythms. The interplay between sleep and meal timing underscores the importance of maintaining circadian alignment in order to avoid creating a metabolic environment conducive to carcinogenesis following the molecular and systemic disruption of metabolic performance and immune function. The chronicity of such a condition may support the initiation and progression of cancer through a variety of mechanisms, including increased oxidative stress, immune suppression, and the activation of proliferative signaling pathways. This review aims to summarize current evidence from human studies and provide an overview of the potential mechanisms underscoring the role of chrononutrition (including time-restricted eating) on cancer risk. Current evidence shows that the morning chronotype, suggesting an alignment between physiological circadian rhythms and eating timing, is associated with a lower risk of cancer. Also, early time-restricted eating and prolonged nighttime fasting were also associated with a lower risk of cancer. The current evidence suggests that the chronotype influences cancer risk through cell cycle regulation, the modulation of metabolic pathways and inflammation, and gut microbiota fluctuations. In conclusion, although there are no clear guidelines on this matter, emerging evidence supports the hypothesis that the role of time-related eating (i.e., time/calorie-restricted feeding and intermittent/periodic fasting) could potentially lead to a reduced risk of cancer. metadata Godos, Justyna; Currenti, Walter; Ferri, Raffaele; Lanza, Giuseppe; Caraci, Filippo; Frias-Toral, Evelyn; Guglielmetti, Monica; Ferraris, Cinzia; Lipari, Vivian; Carvajal Altamiranda, Stefanía; Galvano, Fabio; Castellano, Sabrina y Grosso, Giuseppe mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, vivian.lipari@uneatlantico.es, stefania.carvajal@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR <http://repositorio.unini.edu.mx/id/eprint/16759/1/nutrients-17-00529.pdf> (2025) Chronotype and Cancer: Emerging Relation Between Chrononutrition and Oncology from Human Studies. Nutrients, 17 (3). p. 529. ISSN 2072-6643 document_url: http://repositorio.unini.edu.mx/id/eprint/16759/1/nutrients-17-00529.pdf