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primary topic: Molecular mechanisms underlying the neuroprotective effects of polyphenols: implications for cognitive function

Molecular mechanisms underlying the neuroprotective effects of polyphenols: implications for cognitive function
type: AcademicArticle
type: Article
abstract: Polyphenols are naturally occurring compounds that can be found in plant-based foods, including fruits, vegetables, nuts, seeds, herbs, spices, and beverages, the use of which has been linked to enhanced brain health and cognitive function. These natural molecules are broadly classified into two main groups: flavonoids and non-flavonoid polyphenols, the latter including phenolic acids, stilbenes, and tannins. Flavonoids are primarily known for their potent antioxidant properties, which help neutralize harmful reactive oxygen species (ROS) in the brain, thereby reducing oxidative stress, a key contributor to neurodegenerative diseases. In addition to their antioxidant effects, flavonoids have been shown to modulate inflammation, enhance neuronal survival, and support neurogenesis, all of which are critical for maintaining cognitive function. Phenolic acids possess strong antioxidant properties and are believed to protect brain cells from oxidative damage. Neuroprotective effects of these molecules can also depend on their ability to modulate signaling pathways associated with inflammation and neuronal apoptosis. Among polyphenols, hydroxycinnamic acids such as caffeic acid have been shown to enhance blood-brain barrier permeability, which may increase the delivery of other protective compounds to the brain. Another compound of interest is represented by resveratrol, a stilbene extensively studied for its potential neuroprotective properties related to its ability to activate the sirtuin pathway, a molecular signaling pathway involved in cellular stress response and aging. Lignans, on the other hand, have shown promise in reducing neuroinflammation and oxidative stress, which could help slow the progression of neurodegenerative diseases and cognitive decline. Polyphenols belonging to different subclasses, such as flavonoids, phenolic acids, stilbenes, and lignans, exert neuroprotective effects by regulating microglial activation, suppressing pro-inflammatory cytokines…
date: 2025-09
volume: 24
is part of: EXCLI journal
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Molecular mechanisms underlying the neuroprotective effects of polyphenols: implications for cognitive function (Texto)
has document: Molecular mechanisms underlying the neuroprotective effects of polyphenols: implications for cognitive function (Otro)
subject: Biomedicine
subject: Nutrition

Molecular mechanisms underlying the neuroprotective effects of polyphenols: implications for cognitive function (Texto)
type: Document
has file: excli2025-8779.pdf
has part: excli2025-8779.pdf

EXCLI journal
type: Collection
issn: 16112156

Maurizio Battino
type: Person
given name: Maurizio
family name: Battino

Agnieszka Micek
type: Person
given name: Agnieszka
family name: Micek

Justyna Godos
type: Person
given name: Justyna
family name: Godos

Francesca Giampieri
type: Person
given name: Francesca
family name: Giampieri

José L. Quiles
type: Person
given name: José L.
family name: Quiles

Evelyn Frias-Toral
type: Person
given name: Evelyn
family name: Frias-Toral

Giuseppe Caruso
type: Person
given name: Giuseppe
family name: Caruso

Carmen Lilí Rodríguez Velasco
type: Person
given name: Carmen Lilí
family name: Rodríguez Velasco

Julién Brito Ballester
type: Person
given name: Julién
family name: Brito Ballester

Giuseppe Carota
type: Person
given name: Giuseppe
family name: Carota

Molecular mechanisms underlying the neuroprotective effects of polyphenols: implications for cognitive function (Otro)
type: Document
is version of: Molecular mechanisms underlying the neuroprotective effects of polyphenols: implications for cognitive function (Texto)
is volatile version of: Molecular mechanisms underlying the neuroprotective effects of polyphenols: implications for cognitive function (Texto)
is index codes version of: Molecular mechanisms underlying the neuroprotective effects of polyphenols: implications for cognitive function (Texto)
has file: indexcodes.txt
has part: indexcodes.txt

HTML Summary of #17857 Molecular mechanisms underlying the neuroprotective effects of polyphenols: implications for cognitive function
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primary topic: Molecular mechanisms underlying the neuroprotective effects of polyphenols: implications for cognitive function

Biomedicine
type: Concept
preferred label: Biomedicina @es

Nutrition
type: Concept
preferred label: Alimentación @es