eprintid: 2124 rev_number: 8 eprint_status: archive userid: 2 dir: disk0/00/00/21/24 datestamp: 2022-05-31 18:33:45 lastmod: 2023-07-12 23:30:19 status_changed: 2022-05-31 18:33:45 type: article metadata_visibility: show creators_name: Chapartegui-González, Itziar creators_name: Lázaro-Díez, María creators_name: Ramos Vivas, Jose creators_id: creators_id: creators_id: jose.ramos@uneatlantico.es title: Genetic Resistance Determinants in Clinical Acinetobacter pittii Genomes ispublished: pub subjects: uneat_bm divisions: uneatlantico_produccion_cientifica divisions: uninimx_produccion_cientifica full_text_status: public keywords: Acinetobacter pittii; WGS; MDR; plasmid; nosocomial abstract: Antimicrobial-resistant pathogenic bacteria are an increasing problem in public health, especially in the healthcare environment, where nosocomial infection microorganisms find their niche. Among these bacteria, the genus Acinetobacter which belongs to the ESKAPE pathogenic group harbors different multi-drug resistant (MDR) species that cause human nosocomial infections. Although A. baumannii has always attracted more interest, the close-related species A. pittii is the object of more study due to the increase in its isolation and MDR strains. In this work, we present the genomic analysis of five clinically isolated A. pittii strains from a Spanish hospital, with special attention to their genetic resistance determinants and plasmid structures. All the strains harbored different genes related to β-lactam resistance, as well as different MDR efflux pumps. We also found and described, for the first time in this species, point mutations that seem linked with colistin resistance, which highlights the relevance of this comparative analysis among the pathogenic species isolates. date: 2022-05 date_type: published publication: Antibiotics volume: 11 number: 5 pagerange: 676 id_number: doi:10.3390/antibiotics11050676 refereed: TRUE issn: 2079-6382 official_url: http://doi.org/10.3390/antibiotics11050676 access: open language: en citation: Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Producción Científica Universidad Internacional Iberoamericana México > Investigación > Producción Científica Abierto Inglés Antimicrobial-resistant pathogenic bacteria are an increasing problem in public health, especially in the healthcare environment, where nosocomial infection microorganisms find their niche. Among these bacteria, the genus Acinetobacter which belongs to the ESKAPE pathogenic group harbors different multi-drug resistant (MDR) species that cause human nosocomial infections. Although A. baumannii has always attracted more interest, the close-related species A. pittii is the object of more study due to the increase in its isolation and MDR strains. In this work, we present the genomic analysis of five clinically isolated A. pittii strains from a Spanish hospital, with special attention to their genetic resistance determinants and plasmid structures. All the strains harbored different genes related to β-lactam resistance, as well as different MDR efflux pumps. We also found and described, for the first time in this species, point mutations that seem linked with colistin resistance, which highlights the relevance of this comparative analysis among the pathogenic species isolates. metadata Chapartegui-González, Itziar; Lázaro-Díez, María y Ramos Vivas, Jose mail SIN ESPECIFICAR, SIN ESPECIFICAR, jose.ramos@uneatlantico.es (2022) Genetic Resistance Determinants in Clinical Acinetobacter pittii Genomes. Antibiotics, 11 (5). p. 676. ISSN 2079-6382 document_url: http://repositorio.unini.edu.mx/id/eprint/2124/1/antibiotics-11-00676.pdf