TY  - JOUR
N2  - Dietary polyphenols have been recently proposed as activators of the AMP-activated protein kinase (AMPK) signaling pathway and this fact might explain the relationship between the consumption of polyphenol-rich foods and the slowdown of the progression of aging. In the present work, the effects of strawberry consumption were evaluated on biomarkers of oxidative damage and on aging-associated reductions in mitochondrial function and biogenesis for 8weeks in old rats. Strawberry supplementation increased antioxidant enzyme activities, mitochondrial biomass and functionality, and decreased intracellular ROS levels and biomarkers of protein, lipid and DNA damage (P<0.05). Furthermore, a significant (P<0.05) increase in the expression of the AMPK cascade genes, involved in mitochondrial biogenesis and antioxidant defences, was also detected after strawberry intake. These in vivo results were then verified in vitro on HepG2 cells, confirming the involvement of AMPK in the beneficial effects exerted by strawberry against aging progression.
KW  - AMPK activation; Aging; Mitochondrial functionality; Oxidative stress; Strawberry polyphenols.
Y1  - 2017///
VL  - 234
ID  - uninimx563
SN  - 03088146
AV  - none
EP  - 471
A1  - Giampieri, Francesca
A1  - Alvarez-Suarez, Josč M.
A1  - Cordero, Mario D.
A1  - Gasparrini, Massimiliano
A1  - Forbes-Hernandez, Tamara Y.
A1  - Afrin, Sadia
A1  - Santos-Buelga, Celestino
A1  - González-Paramás, Ana M.
A1  - Astolfi, Paola
A1  - Rubini, Corrado
A1  - Zizzi, Antonio
A1  - Tulipani, Sara
A1  - Quiles, Josč L.
A1  - Mezzetti, Bruno
A1  - Battino, Maurizio
JF  - Food Chemistry
UR  - http://doi.org/10.1016/j.foodchem.2017.05.017
TI  - Strawberry consumption improves aging-associated impairments, mitochondrial biogenesis and functionality through the AMP-activated protein kinase signaling cascade
SP  - 464
ER  -