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Abierto Inglés Automated dental imaging interpretation is one of the most prolific areas of research using artificial intelligence. X-ray imaging systems have enabled dental clinicians to identify dental diseases. However, the manual process of dental disease assessment is tedious and error-prone when diagnosed by inexperienced dentists. Thus, researchers have employed different advanced computer vision techniques, as well as machine and deep learning models for dental disease diagnoses using X-ray imagery. In this regard, a lightweight Mask-RCNN model is proposed for periapical disease detection. The proposed model is constructed in two parts: a lightweight modified MobileNet-v2 backbone and region-based network (RPN) are proposed for periapical disease localization on a small dataset. To measure the effectiveness of the proposed model, the lightweight Mask-RCNN is evaluated on a custom annotated dataset comprising images of five different types of periapical lesions. The results reveal that the model can detect and localize periapical lesions with an overall accuracy of 94%, a mean average precision of 85%, and a mean insection over a union of 71.0%. The proposed model improves the detection, classification, and localization accuracy significantly using a smaller number of images compared to existing methods and outperforms state-of-the-art approaches metadata Fatima, Anum; Shafi, Imran; Afzal, Hammad; Mahmood, Khawar; Díez, Isabel de la Torre; Lipari, Vivian; Brito Ballester, Julién y Ashraf, Imran mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, vivian.lipari@uneatlantico.es, julien.brito@uneatlantico.es, SIN ESPECIFICAR (2023) Deep Learning-Based Multiclass Instance Segmentation for Dental Lesion Detection. Healthcare, 11 (3). p. 347. ISSN 2227-9032