eprintid: 5793 rev_number: 6 eprint_status: archive userid: 2 dir: disk0/00/00/57/93 datestamp: 2023-02-09 23:30:08 lastmod: 2023-02-09 23:30:08 status_changed: 2023-02-09 23:30:08 type: article metadata_visibility: show creators_name: Cassotta, Manuela creators_name: Cianciosi, Danila creators_name: De Giuseppe, Rachele creators_name: Navarro-Hortal, Maria Dolores creators_name: Diaz, Yasmany Armas creators_name: Forbes-Hernández, Tamara Yuliett creators_name: Tutusaus, Kilian creators_name: Pascual Barrera, Alina Eugenia creators_name: Grosso, Giuseppe creators_name: Xiao, Jianbo creators_name: Battino, Maurizio creators_name: Giampieri, Francesca creators_id: manucassotta@gmail.com creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: kilian.tutusaus@uneatlantico.es creators_id: alina.pascual@unini.edu.mx creators_id: creators_id: creators_id: maurizio.battino@uneatlantico.es creators_id: francesca.giampieri@uneatlantico.es title: Possible role of nutrition in the prevention of Inflammatory Bowel Disease-related colorectal cancer: a focus on human studies ispublished: pub subjects: uneat_sn divisions: uneatlantico_produccion_cientifica divisions: uninimx_produccion_cientifica divisions: unic_produccion_cientifica full_text_status: none keywords: diet; colitis-associated cancer; CAC; CRC; IBD-colorectal cancer abstract: Inflammatory bowel disease (IBD) patients are at substantially higher risk of colorectal cancer (CRC) and IBD-associated CRC accounts for roughly 10-15% of the annual mortality in IBD patients. IBD-related CRC also affects younger patients if compared with sporadic CRC, with a 5-year survival rate of 50%. Regardless of medical therapies, the persistent inflammation state characterizing IBD raises the risk for precancerous changes and CRC, with additional input from several elements including genetic and environmental risk factors, IBD-associated comorbidities, intestinal barrier disfunction, and gut microbiota modifications. It is well known that nutritional habits and dietary bioactive compounds can influence IBD-associated inflammation, microbiome abundance and composition, oxidative stress balance, and gut permeability. In addition, in the last years, results from broad epidemiological and experimental studies have associated certain foods or nutritional patterns with the risk of colorectal neoplasia. Here we review the possible role of nutrition in the prevention of IBD-related CRC, focusing specifically on human studies. In conclusion it emerges that nutritional interventions based on healthy, nutrient-dense dietary patterns characterized by a high intake of fiber, vegetables, fruit, Omega-3 PUFAs, and low amount of animal proteins, processed foods and alcohol, combined with probiotic supplementation have the potential of reducing IBD-activity and preventing the risk of IBD-related CRC through different mechanisms, suggesting that targeted nutritional interventions may represent a novel promising approach for the prevention and management of IBD-associated CRC. date: 2023 publication: Nutrition pagerange: 111980 id_number: doi:10.1016/j.nut.2023.111980 refereed: TRUE issn: 08999007 official_url: http://doi.org/10.1016/j.nut.2023.111980 access: close language: en citation: Artículo Materias > Alimentación <http://repositorio.unini.edu.mx/view/subjects/uneat=5Fsn.html> Universidad Europea del Atlántico > Investigación > Producción Científica <http://repositorio.unini.edu.mx/view/divisions/uneatlantico=5Fproduccion=5Fcientifica.html> Universidad Internacional Iberoamericana México > Investigación > Artículos y libros <http://repositorio.unini.edu.mx/view/divisions/uninimx=5Fproduccion=5Fcientifica.html> Universidad Internacional do Cuanza > Investigación > Producción Científica <http://repositorio.unini.edu.mx/view/divisions/unic=5Fproduccion=5Fcientifica.html> Cerrado Inglés Inflammatory bowel disease (IBD) patients are at substantially higher risk of colorectal cancer (CRC) and IBD-associated CRC accounts for roughly 10-15% of the annual mortality in IBD patients. IBD-related CRC also affects younger patients if compared with sporadic CRC, with a 5-year survival rate of 50%. Regardless of medical therapies, the persistent inflammation state characterizing IBD raises the risk for precancerous changes and CRC, with additional input from several elements including genetic and environmental risk factors, IBD-associated comorbidities, intestinal barrier disfunction, and gut microbiota modifications. It is well known that nutritional habits and dietary bioactive compounds can influence IBD-associated inflammation, microbiome abundance and composition, oxidative stress balance, and gut permeability. In addition, in the last years, results from broad epidemiological and experimental studies have associated certain foods or nutritional patterns with the risk of colorectal neoplasia. Here we review the possible role of nutrition in the prevention of IBD-related CRC, focusing specifically on human studies. In conclusion it emerges that nutritional interventions based on healthy, nutrient-dense dietary patterns characterized by a high intake of fiber, vegetables, fruit, Omega-3 PUFAs, and low amount of animal proteins, processed foods and alcohol, combined with probiotic supplementation have the potential of reducing IBD-activity and preventing the risk of IBD-related CRC through different mechanisms, suggesting that targeted nutritional interventions may represent a novel promising approach for the prevention and management of IBD-associated CRC. metadata Cassotta, Manuela; Cianciosi, Danila; De Giuseppe, Rachele; Navarro-Hortal, Maria Dolores; Diaz, Yasmany Armas; Forbes-Hernández, Tamara Yuliett; Tutusaus, Kilian; Pascual Barrera, Alina Eugenia; Grosso, Giuseppe; Xiao, Jianbo; Battino, Maurizio y Giampieri, Francesca mail manucassotta@gmail.com, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, kilian.tutusaus@uneatlantico.es, alina.pascual@unini.edu.mx, SIN ESPECIFICAR, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es, francesca.giampieri@uneatlantico.es (2023) Possible role of nutrition in the prevention of Inflammatory Bowel Disease-related colorectal cancer: a focus on human studies. Nutrition. p. 111980. ISSN 08999007