TY  - JOUR
VL  - 15
AV  - public
JF  - Viruses
ID  - uninimx6097
UR  - http://doi.org/10.3390/v15020505
SN  - 1999-4915
A1  - Bakkas, Jamal
A1  - Hanine, Mohamed
A1  - Chekry, Abderrahman
A1  - Gounane, Said
A1  - de la Torre Díez, Isabel
A1  - Lipari, Vivian
A1  - Martínez López, Nohora Milena
A1  - Ashraf, Imran
N2  - Mutations allow viruses to continuously evolve by changing their genetic code to adapt to the hosts they infect. It is an adaptive and evolutionary mechanism that helps viruses acquire characteristics favoring their survival and propagation. The COVID-19 pandemic declared by the WHO in March 2020 is caused by the SARS-CoV-2 virus. The non-stop adaptive mutations of this virus and the emergence of several variants over time with characteristics favoring their spread constitute one of the biggest obstacles that researchers face in controlling this pandemic. Understanding the mutation mechanism allows for the adoption of anticipatory measures and the proposal of strategies to control its propagation. In this study, we focus on the mutations of this virus, and we propose the SARSMutOnto ontology to model SARS-CoV-2 mutations reported by Pango researchers. A detailed description is given for each mutation. The genes where the mutations occur and the genomic structure of this virus are also included. The sub-lineages and the recombinant sub-lineages resulting from these mutations are additionally represented while maintaining their hierarchy. We developed a Python-based tool to automatically generate this ontology from various published Pango source files. At the end of this paper, we provide some examples of SPARQL queries that can be used to exploit this ontology. SARSMutOnto might become a ?wet bench? machine learning tool for predicting likely future mutations based on previous mutations.
TI  - SARSMutOnto: An Ontology for SARS-CoV-2 Lineages and Mutations
IS  - 2
Y1  - 2023///
KW  - ontology; genome structure; SARS-CoV-2; mutation; lineage
ER  -