@article{uninimx612,
           title = {Polyphenol-Rich Strawberry Extract Protects Human Dermal Fibroblasts against Hydrogen Peroxide Oxidative Damage and Improves Mitochondrial Functionality},
           pages = {7798--7816},
          number = {6},
          author = {Francesca Giampieri and Jos{\'e} Alvarez-Suarez and Luca Mazzoni and Tamara Y. Forbes-Hernandez and Massimiliano Gasparrini and Ana Gonz{\`a}lez-Param{\`a}s and Celestino Santos-Buelga and Jos{\'e} Quiles and Stefano Bompadre and Bruno Mezzetti and Maurizio Battino},
          volume = {19},
         journal = {Molecules},
            year = {2014},
        keywords = {strawberry; anthocyanin; ROS; lipid peroxidation; DNA damage; fibroblasts},
        abstract = {Strawberry bioactive compounds are widely known to be powerful antioxidants. In this study, the antioxidant and anti-aging activities of a polyphenol-rich strawberry extract were evaluated using human dermal fibroblasts exposed to H2O2. Firstly, the phenol and flavonoid contents of strawberry extract were studied, as well as the antioxidant capacity. HPLC-DAD analysis was performed to determine the vitamin C and {\ensuremath{\beta}}-carotene concentration, while HPLC-DAD/ESI-MS analysis was used for anthocyanin identification. Strawberry extract presented a high antioxidant capacity, and a relevant concentration of vitamins and phenolics. Pelargonidin- and cyanidin-glycosides were the most representative anthocyanin components of the fruits. Fibroblasts incubated with strawberry extract and stressed with H2O2 showed an increase in cell viability, a smaller intracellular amount of ROS, and a reduction of membrane lipid peroxidation and DNA damage. Strawberry extract was also able to improve mitochondrial functionality, increasing the basal respiration of mitochondria and to promote a regenerative capacity of cells after exposure to pro-oxidant stimuli. These findings confirm that strawberries possess antioxidant properties and provide new insights into the beneficial role of strawberry bioactive compounds on protecting skin from oxidative stress and aging.},
             url = {http://repositorio.unini.edu.mx/id/eprint/612/}
}