TY  - JOUR
KW  - Nigella sativa
KW  -  Nutritional composition
KW  -  Anticancer properties
KW  -  Molecular pathways
KW  -  Combined therapy.
VL  - 26
UR  - http://doi.org/10.3390/molecules26082108
SN  - 1420-3049
TI  - Nutritional Value and Preventive Role of Nigella sativa L. and Its Main Component Thymoquinone in Cancer: An Evidenced-Based Review of Preclinical and Clinical Studies
AV  - public
ID  - uninimx77
N2  - In recent times, scientific attention has been paid to different foods and their bioactive components for the ability to inhibit the onset and progress of different types of cancer. Nigella sativa extract, powder and seed oil and its main components, thymoquinone and ?-hederin, have showed potent anticancer and chemosensitizing effects against various types of cancer, such as liver, colon, breast, renal, cervical, lung, ovarian, pancreatic, prostate and skin tumors, through the modulation of various molecular signaling pathways. Herein, the purpose of this review was to highlight the anticancer activity of Nigella sativa and it constitutes, focusing on different in vitro, in vivo and clinical studies and projects, in order to underline their antiproliferative, proapoptotic, cytotoxic and antimetastatic effects. Particular attention has been also given to the synergistic effect of Nigella sativa and it constitutes with chemotherapeutic drugs, and to the synthesized analogs of thymoquinone that seem to enhance the chemo-sensitizing potential. This review could be a useful step towards new research on N. sativa and cancer, to include this plant in the dietary treatments in support to conventional therapies, for the best achievement of therapeutic goals.
A1  - Ansary, Johura
A1  - Giampieri, Francesca
A1  - Forbes-Hernandez, Tamara Y.
A1  - Regolo, Lucia
A1  - Quinzi, Denise
A1  - Gracia Villar, Santos
A1  - Garcia Villena, Eduardo
A1  - Tutusaus, Kilian
A1  - Alvarez-Suarez, José M.
A1  - Battino, Maurizio
A1  - Cianciosi, Danila
Y1  - 2021/04//
IS  - 8
JF  - Molecules
ER  -