eprintid: 77 rev_number: 24 eprint_status: archive userid: 2 importid: 0 dir: disk0/00/00/00/77 datestamp: 2021-11-08 15:59:12 lastmod: 2023-07-07 23:30:08 status_changed: 2021-11-08 15:59:12 type: article succeeds: 0 commentary: 0 metadata_visibility: show item_issues_count: 0 sword_depositor: 0 creators_name: Ansary, Johura creators_name: Giampieri, Francesca creators_name: Forbes-Hernandez, Tamara Y. creators_name: Regolo, Lucia creators_name: Quinzi, Denise creators_name: Gracia Villar, Santos creators_name: Garcia Villena, Eduardo creators_name: Tutusaus, Kilian creators_name: Alvarez-Suarez, José M. creators_name: Battino, Maurizio creators_name: Cianciosi, Danila creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: santos.gracia@uneatlantico.es creators_id: eduardo.garcia@uneatlantico.es creators_id: kilian.tutusaus@uneatlantico.es creators_id: creators_id: creators_id: title: Nutritional Value and Preventive Role of Nigella sativa L. and Its Main Component Thymoquinone in Cancer: An Evidenced-Based Review of Preclinical and Clinical Studies ispublished: pub subjects: uneat_sn divisions: uneatlantico_produccion_cientifica divisions: uninimx_produccion_cientifica full_text_status: public keywords: Nigella sativa, Nutritional composition, Anticancer properties, Molecular pathways, Combined therapy. abstract: In recent times, scientific attention has been paid to different foods and their bioactive components for the ability to inhibit the onset and progress of different types of cancer. Nigella sativa extract, powder and seed oil and its main components, thymoquinone and α-hederin, have showed potent anticancer and chemosensitizing effects against various types of cancer, such as liver, colon, breast, renal, cervical, lung, ovarian, pancreatic, prostate and skin tumors, through the modulation of various molecular signaling pathways. Herein, the purpose of this review was to highlight the anticancer activity of Nigella sativa and it constitutes, focusing on different in vitro, in vivo and clinical studies and projects, in order to underline their antiproliferative, proapoptotic, cytotoxic and antimetastatic effects. Particular attention has been also given to the synergistic effect of Nigella sativa and it constitutes with chemotherapeutic drugs, and to the synthesized analogs of thymoquinone that seem to enhance the chemo-sensitizing potential. This review could be a useful step towards new research on N. sativa and cancer, to include this plant in the dietary treatments in support to conventional therapies, for the best achievement of therapeutic goals. date: 2021-04 date_type: published publication: Molecules volume: 26 number: 8 pagerange: 2108 pages: 0 id_number: doi:10.3390/molecules26082108 refereed: TRUE issn: 1420-3049 official_url: http://doi.org/10.3390/molecules26082108 num_pieces: 0 gscholar_impact: 0 gscholar_datestamp: 0000-00-00 00:00:00 access: open language: en citation: Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica Universidad Internacional Iberoamericana México > Investigación > Producción Científica Abierto Inglés In recent times, scientific attention has been paid to different foods and their bioactive components for the ability to inhibit the onset and progress of different types of cancer. Nigella sativa extract, powder and seed oil and its main components, thymoquinone and α-hederin, have showed potent anticancer and chemosensitizing effects against various types of cancer, such as liver, colon, breast, renal, cervical, lung, ovarian, pancreatic, prostate and skin tumors, through the modulation of various molecular signaling pathways. Herein, the purpose of this review was to highlight the anticancer activity of Nigella sativa and it constitutes, focusing on different in vitro, in vivo and clinical studies and projects, in order to underline their antiproliferative, proapoptotic, cytotoxic and antimetastatic effects. Particular attention has been also given to the synergistic effect of Nigella sativa and it constitutes with chemotherapeutic drugs, and to the synthesized analogs of thymoquinone that seem to enhance the chemo-sensitizing potential. This review could be a useful step towards new research on N. sativa and cancer, to include this plant in the dietary treatments in support to conventional therapies, for the best achievement of therapeutic goals. metadata Ansary, Johura; Giampieri, Francesca; Forbes-Hernandez, Tamara Y.; Regolo, Lucia; Quinzi, Denise; Gracia Villar, Santos; Garcia Villena, Eduardo; Tutusaus, Kilian; Alvarez-Suarez, José M.; Battino, Maurizio y Cianciosi, Danila mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, santos.gracia@uneatlantico.es, eduardo.garcia@uneatlantico.es, kilian.tutusaus@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR (2021) Nutritional Value and Preventive Role of Nigella sativa L. and Its Main Component Thymoquinone in Cancer: An Evidenced-Based Review of Preclinical and Clinical Studies. Molecules, 26 (8). p. 2108. ISSN 1420-3049 document_url: http://repositorio.unini.edu.mx/id/eprint/77/1/molecules-26-02108-v2.pdf