eprintid: 8725 rev_number: 9 eprint_status: archive userid: 2 dir: disk0/00/00/87/25 datestamp: 2023-09-08 23:30:10 lastmod: 2023-09-08 23:30:12 status_changed: 2023-09-08 23:30:10 type: article metadata_visibility: show creators_name: Shahzadi, Samra creators_name: Butt, Naveed Anwer creators_name: Sana, Muhammad Usman creators_name: Elío Pascual, Iñaki creators_name: Briones Urbano, Mercedes creators_name: Díez, Isabel de la Torre creators_name: Ashraf, Imran creators_id: creators_id: creators_id: creators_id: inaki.elio@uneatlantico.es creators_id: mercedes.briones@uneatlantico.es creators_id: creators_id: title: Voxel Extraction and Multiclass Classification of Identified Brain Regions across Various Stages of Alzheimer’s Disease Using Machine Learning Approaches ispublished: pub subjects: uneat_bm subjects: uneat_eng divisions: uneatlantico_produccion_cientifica divisions: unincol_produccion_cientifica divisions: uninimx_produccion_cientifica divisions: uninipr_produccion_cientifica divisions: unic_produccion_cientifica full_text_status: public keywords: Alzheimer’s disease detection; classification; machine learning abstract: This study sought to investigate how different brain regions are affected by Alzheimer’s disease (AD) at various phases of the disease, using independent component analysis (ICA). The study examines six regions in the mild cognitive impairment (MCI) stage, four in the early stage of Alzheimer’s disease (AD), six in the moderate stage, and six in the severe stage. The precuneus, cuneus, middle frontal gyri, calcarine cortex, superior medial frontal gyri, and superior frontal gyri were the areas impacted at all phases. A general linear model (GLM) is used to extract the voxels of the previously mentioned regions. The resting fMRI data for 18 AD patients who had advanced from MCI to stage 3 of the disease were obtained from the ADNI public source database. The subjects include eight women and ten men. The voxel dataset is used to train and test ten machine learning algorithms to categorize the MCI, mild, moderate, and severe stages of Alzheimer’s disease. The accuracy, recall, precision, and F1 score were used as conventional scoring measures to evaluate the classification outcomes. AdaBoost fared better than the other algorithms and obtained a phenomenal accuracy of 98.61%, precision of 99.00%, and recall and F1 scores of 98.00% each. date: 2023-09 publication: Diagnostics volume: 13 number: 18 pagerange: 2871 id_number: doi:10.3390/diagnostics13182871 refereed: TRUE issn: 2075-4418 official_url: http://doi.org/10.3390/diagnostics13182871 access: open language: en citation: Artículo Materias > Biomedicina Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Producción Científica Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica Universidad Internacional Iberoamericana México > Investigación > Producción Científica Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica Universidad Internacional do Cuanza > Investigación > Producción Científica Abierto Inglés This study sought to investigate how different brain regions are affected by Alzheimer’s disease (AD) at various phases of the disease, using independent component analysis (ICA). The study examines six regions in the mild cognitive impairment (MCI) stage, four in the early stage of Alzheimer’s disease (AD), six in the moderate stage, and six in the severe stage. The precuneus, cuneus, middle frontal gyri, calcarine cortex, superior medial frontal gyri, and superior frontal gyri were the areas impacted at all phases. A general linear model (GLM) is used to extract the voxels of the previously mentioned regions. The resting fMRI data for 18 AD patients who had advanced from MCI to stage 3 of the disease were obtained from the ADNI public source database. The subjects include eight women and ten men. The voxel dataset is used to train and test ten machine learning algorithms to categorize the MCI, mild, moderate, and severe stages of Alzheimer’s disease. The accuracy, recall, precision, and F1 score were used as conventional scoring measures to evaluate the classification outcomes. AdaBoost fared better than the other algorithms and obtained a phenomenal accuracy of 98.61%, precision of 99.00%, and recall and F1 scores of 98.00% each. metadata Shahzadi, Samra; Butt, Naveed Anwer; Sana, Muhammad Usman; Elío Pascual, Iñaki; Briones Urbano, Mercedes; Díez, Isabel de la Torre y Ashraf, Imran mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, inaki.elio@uneatlantico.es, mercedes.briones@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR (2023) Voxel Extraction and Multiclass Classification of Identified Brain Regions across Various Stages of Alzheimer’s Disease Using Machine Learning Approaches. Diagnostics, 13 (18). p. 2871. ISSN 2075-4418 document_url: http://repositorio.unini.edu.mx/id/eprint/8725/1/diagnostics-13-02871.pdf