TY  - JOUR
IS  - 10
Y1  - 2023/10//
KW  - clinical features
KW  -  epidemiology
KW  -  monkeypox
KW  -  transmission
VL  - 6
AV  - public
JF  - Health Science Reports
A1  - Sharif, Nadim
A1  - Sharif, Nazmul
A1  - Alzahrani, Khalid J.
A1  - Halawani, Ibrahim F.
A1  - Alzahrani, Fuad M.
A1  - Díez, Isabel De la Torre
A1  - Lipari, Vivian
A1  - López Flores, Miguel Ángel
A1  - Parvez, Anowar K.
A1  - Dey, Shuvra K.
TI  - Molecular epidemiology, transmission and clinical features of 2022?mpox outbreak: A systematic review
N2  - Background and Aims
The 2022-mpox outbreak has spread worldwide in a short time. Integrated knowledge of the epidemiology, clinical characteristics, and transmission of mpox are limited. This systematic review of peer-reviewed articles and gray literature was conducted to shed light on the epidemiology, clinical features, and transmission of 2022-mpox outbreak.

Methods
We identified 45 peer-reviewed manuscripts for data analysis. The standards of the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) Statement and Cochrane Collaboration were followed for conducting the study.

Results
The case number of mpox has increased about 100 times worldwide. About 99% of the cases in 2022 outbreak was from non-endemic regions. Men (70%?98% cases) were mostly infected with homosexual and bisexual behavior (30%?60%). The ages of the infected people ranged between 30 and 40 years. The presence of HIV and sexually transmitted infections among 30%?60% of cases were reported. Human-to-human transmission via direct contact and different body fluids were involved in the majority of the cases (90%?100%). Lesions in genitals, perianal, and anogenital areas were more prevalent. Unusually, pharyngitis (15%?40%) and proctitis (20%?40%) were more common during 2022 outbreak than pre-2022 outbreaks. Brincidofovir is approved for the treatment of smallpox by FDA (USA). Two vaccines, including JYNNEOSTM and ACAM2000®, are approved and used for pre- and post-prophylaxis in cases. About 100% of the cases in non-endemic regions were associated with isolates of IIb clade with a divergence of 0.0018?0.0035. Isolates from B.1 lineage were the most predominant followed by B.1.2 and B.1.10.

Conclusion
This study will add integrated knowledge of the epidemiology, clinical features, and transmission of mpox.
UR  - http://doi.org/10.1002/hsr2.1603
ID  - uninimx9232
SN  - 2398-8835
ER  -