TY  - JOUR
UR  - http://doi.org/10.1016/j.phrs.2014.10.007
ID  - uninimx98
SP  - 1
SN  - 10436618
A1  - Bullón, Pedro
A1  - Román-Malo, Lourdes
A1  - Marín-Aguilar, Fabiola
A1  - Alvarez-Suarez, José Miguel
A1  - Giampieri, Francesca
A1  - Battino, Maurizio
A1  - Cordero, Mario D.
N2  - Oxidative stress is implicated in several infectious diseases. In this regard, lipopolysaccharide (LPS), an endotoxic component, induces mitochondrial dysfunction and oxidative stress in several pathological events such as periodontal disease or sepsis. In our experiments, LPS-treated fibroblasts provoked increased oxidative stress, mitochondrial dysfunction, reduced oxygen consumption and mitochondrial biogenesis. After comparing coenzyme Q10 (CoQ10) and N-acetylcysteine (NAC), we observed a more significant protection of CoQ10 than of NAC, which was comparable with other lipophilic and hydrophilic antioxidants such as vitamin E or BHA respectively. CoQ10 improved mitochondrial biogenesis by activating PGC-1? and TFAM. This lipophilic antioxidant protection was observed in mice after LPS injection. These results show that mitochondria-targeted lipophilic antioxidants could be a possible specific therapeutic strategy in pharmacology in the treatment of infectious diseases and their complications.
TI  - Lipophilic antioxidants prevent lipopolysaccharide-induced mitochondrial dysfunction through mitochondrial biogenesis improvement
AV  - none
VL  - 91
JF  - Pharmacological Research
KW  - Porphyromonas gingivalis; Lipopolysaccharide; Coenzyme Q10; N-acetylcysteine; Mitochondria
EP  - 8
Y1  - 2015///
ER  -