Efecto de un Alimento Funcional a base de Lenteja y Aceite de Capulín, Sobre un Modelo Experimental Murino con Diabetes Mellitus Tipo 2
Tesis Materias > Alimentación Universidad Internacional Iberoamericana México > Investigación > Tesis Doctorales Cerrado Español Los alimentos funcionales han demostrado científicamente poseer efectos benéficos a la salud, por lo cual se realiza la investigación para identificar la efectividad hipoglucemiante de la lenteja en conjunto con el aceite de capulín, sobre un modelo experimental murino. Se indujo a 4 grupos de ratones diabetes mellitus tipo 2, identificando su estado hipoglucémico mediante la prueba rápida de glucosa capilar para iniciar con la administración de 3 formulaciones de alimentos funcionales y una dieta control durante 14 días, realizando nuevamente la medición de glucosa capilar a cada uno de los ratones el día 7 y 14. Al término de los 14 días se obtiene muestra de sangre de los ratones para realizar análisis clínico de química sanguínea Vl. Los resultados mostraron que el diseño y la formulación de dietas con alimentos funcionales es necesaria para el tratamiento de enfermedades como la diabetes mellitus de tipo 2, por lo que la dieta a base de harina de lenteja en comparación con las dietas de los demás grupos de experimentación demostró una menor progresión del incremento de glucosa capilar y sérica, manteniendo controlados los niveles de colesterol, triglicéridos, urea y creatinina. Por lo que se concluye que la formulación del alimento funcional a base de harina de lenteja reduce los daños celulares y tisulares al tener un efecto hipoglucemiante, hipolipemiante no especifico y favorecer la excreción de compuestos nitrogenados que contribuyen el estrés oxidativo, que se genera en la diabetes mellitus tipo 2. Por lo que el harina de lenteja es un alimento funcional adecuado en los estados hiperglucémicos. metadata Chávez Larios, Iridia mail iridia.chl@gmail.com (2022) Efecto de un Alimento Funcional a base de Lenteja y Aceite de Capulín, Sobre un Modelo Experimental Murino con Diabetes Mellitus Tipo 2. Doctoral thesis, SIN ESPECIFICAR.
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Los alimentos funcionales han demostrado científicamente poseer efectos benéficos a la salud, por lo cual se realiza la investigación para identificar la efectividad hipoglucemiante de la lenteja en conjunto con el aceite de capulín, sobre un modelo experimental murino. Se indujo a 4 grupos de ratones diabetes mellitus tipo 2, identificando su estado hipoglucémico mediante la prueba rápida de glucosa capilar para iniciar con la administración de 3 formulaciones de alimentos funcionales y una dieta control durante 14 días, realizando nuevamente la medición de glucosa capilar a cada uno de los ratones el día 7 y 14. Al término de los 14 días se obtiene muestra de sangre de los ratones para realizar análisis clínico de química sanguínea Vl. Los resultados mostraron que el diseño y la formulación de dietas con alimentos funcionales es necesaria para el tratamiento de enfermedades como la diabetes mellitus de tipo 2, por lo que la dieta a base de harina de lenteja en comparación con las dietas de los demás grupos de experimentación demostró una menor progresión del incremento de glucosa capilar y sérica, manteniendo controlados los niveles de colesterol, triglicéridos, urea y creatinina. Por lo que se concluye que la formulación del alimento funcional a base de harina de lenteja reduce los daños celulares y tisulares al tener un efecto hipoglucemiante, hipolipemiante no especifico y favorecer la excreción de compuestos nitrogenados que contribuyen el estrés oxidativo, que se genera en la diabetes mellitus tipo 2. Por lo que el harina de lenteja es un alimento funcional adecuado en los estados hiperglucémicos.
| Tipo de Documento: | Tesis (Doctoral) |
|---|---|
| Palabras Clave: | Alimento funcional, lentejas, aceite de capulín, aceite de oliva, diabetes mellitus tipo 2, hipoglucemia. |
| Clasificación temática: | Materias > Alimentación |
| Divisiones: | Universidad Internacional Iberoamericana México > Investigación > Tesis Doctorales |
| Depositado: | 21 Sep 2023 23:30 |
| Ultima Modificación: | 21 Sep 2023 23:30 |
| URI: | https://repositorio.unini.edu.mx/id/eprint/1297 |
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A scalable and secure federated learning authentication scheme for IoT
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Background/Objectives: The growing integration of Artificial Intelligence (AI) and chatbots in health professional education offers innovative methods to enhance learning and clinical preparedness. This study aimed to evaluate the educational impact and perceptions in university students of Human Nutrition and Dietetics, regarding the utility, usability, and design of the E+DIEting_Lab chatbot platform when implemented in clinical nutrition training. Methods: The platform was piloted from December 2023 to April 2025 involving 475 students from multiple European universities. While all 475 students completed the initial survey, 305 finished the follow-up evaluation, representing a 36% attrition rate. Participants completed surveys before and after interacting with the chatbots, assessing prior experience, knowledge, skills, and attitudes. Data were analyzed using descriptive statistics and independent samples t-tests to compare pre- and post-intervention perceptions. Results: A total of 475 university students completed the initial survey and 305 the final evaluation. Most university students were females (75.4%), with representation from six languages and diverse institutions. Students reported clear perceived learning gains: 79.7% reported updated practical skills in clinical dietetics and communication were updated, 90% felt that new digital tools improved classroom practice, and 73.9% reported enhanced interpersonal skills. Self-rated competence in using chatbots as learning tools increased significantly, with mean knowledge scores rising from 2.32 to 2.66 and skills from 2.39 to 2.79 on a 0–5 Likert scale (p < 0.001 for both). Perceived effectiveness and usefulness of chatbots as self-learning tools remained positive but showed a small decline after use (effectiveness from 3.63 to 3.42; usefulness from 3.63 to 3.45), suggesting that hands-on experience refined, but did not diminish, students’ overall favorable views of the platform. Conclusions: The implementation and pilot evaluation of the E+DIEting_Lab self-learning virtual patient chatbot platform demonstrate that structured digital simulation tools can significantly improve perceived clinical nutrition competences. These findings support chatbot adoption in dietetics curricula and inform future digital education innovations.
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Suicide Ideation Detection Using Social Media Data and Ensemble Machine Learning Model
Identifying the emotional state of individuals has useful applications, particularly to reduce the risk of suicide. Users’ thoughts on social media platforms can be used to find cues on the emotional state of individuals. Clinical approaches to suicide ideation detection primarily rely on evaluation by psychologists, medical experts, etc., which is time-consuming and requires medical expertise. Machine learning approaches have shown potential in automating suicide detection. In this regard, this study presents a soft voting ensemble model (SVEM) by leveraging random forest, logistic regression, and stochastic gradient descent classifiers using soft voting. In addition, for the robust training of SVEM, a hybrid feature engineering approach is proposed that combines term frequency-inverse document frequency and the bag of words. For experimental evaluation, “Suicide Watch” and “Depression” subreddits on the Reddit platform are used. Results indicate that the proposed SVEM model achieves an accuracy of 94%, better than existing approaches. The model also shows robust performance concerning precision, recall, and F1, each with a 0.93 score. ERT and deep learning models are also used, and performance comparison with these models indicates better performance of the SVEM model. Gated recurrent unit, long short-term memory, and recurrent neural network have an accuracy of 92% while the convolutional neural network obtains an accuracy of 91%. SVEM’s computational complexity is also low compared to deep learning models. Further, this study highlights the importance of explainability in healthcare applications such as suicidal ideation detection, where the use of LIME provides valuable insights into the contribution of different features. In addition, k-fold cross-validation further validates the performance of the proposed approach.
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Human metapneumovirus (hMPV) is one of the potential pandemic pathogens, and it is a concern for elderly subjects and immunocompromised patients. There is no vaccine or specific antiviral available for hMPV. We conducted an in-silico study to predict initial antiviral candidates against human metapneumovirus. Our methodology included protein modeling, stability assessment, molecular docking, molecular simulation, analysis of non-covalent interactions, bioavailability, carcinogenicity, and pharmacokinetic profiling. We pinpointed four plant-derived bio-compounds as antiviral candidates. Among the compounds, apigenin showed the highest binding affinity, with values of − 8.0 kcal/mol for the hMPV-F protein and − 7.6 kcal/mol for the hMPV-N protein. Molecular dynamic simulations and further analyses confirmed that the protein-ligand docked complexes exhibited acceptable stability compared to two standard antiviral drugs. Additionally, these four compounds yielded satisfactory outcomes in bioavailability, drug-likeness, and ADME-Tox (absorption, distribution, metabolism, excretion, and toxicity) and STopTox analyses. This study highlights the potential of apigenin and xanthoangelol E as an initial antiviral candidate, underscoring the necessity for wet-lab evaluation, preclinical and clinical trials against human metapneumovirus infection.
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Introduction: Jackfruit cultivation is highly affected by leaf diseases that reduce yield, fruit quality, and farmer income. Early diagnosis remains challenging due to the limitations of manual inspection and the lack of automated and scalable disease detection systems. Existing deep-learning approaches often suffer from limited generalization and high computational cost, restricting real-time field deployment. Methods: This study proposes CNNAttLSTM, a hybrid deep-learning architecture integrating Convolutional Neural Networks (CNN), Long Short-Term Memory (LSTM) units, and an attention mechanism for multi-class classification of algal leaf spot, black spot, and healthy jackfruit leaves. Each image is divided into ordered 56×56 spatial patches, treated as pseudo-temporal sequences to enable the LSTM to capture contextual dependencies across different leaf regions. Spatial features are extracted via Conv2D, MaxPooling, and GlobalAveragePooling layers; temporal modeling is performed by LSTM units; and an attention mechanism assigns adaptive weights to emphasize disease-relevant regions. Experiments were conducted on a publicly available Kaggle dataset comprising 38,019 images, using predefined training, validation, and testing splits. Results: The proposed CNNAttLSTM model achieved 99% classification accuracy, outperforming the baseline CNN (86%) and CNN–LSTM (98%) models. It required only 3.7 million parameters, trained in 45 minutes on an NVIDIA Tesla T4 GPU, and achieved an inference time of 22 milliseconds per image, demonstrating high computational efficiency. The patch-based pseudo-temporal approach improved spatial–temporal feature representation, enabling the model to distinguish subtle differences between visually similar disease classes. Discussion: Results show that combining spatial feature extraction with temporal modeling and attention significantly enhances robustness and classification performance in plant disease detection. The lightweight design enables real-time and edge-device deployment, addressing a major limitation of existing deep-learning techniques. The findings highlight the potential of CNNAttLSTM for scalable, efficient, and accurate agricultural disease monitoring and broader precision agriculture applications.
Gaurav Tuteja mail , Fuad Ali Mohammed Al-Yarimi mail , Amna Ikram mail , Rupesh Gupta mail , Ateeq Ur Rehman mail , Jeewan Singh mail , Irene Delgado Noya mail irene.delgado@uneatlantico.es, Luis Alonso Dzul López mail luis.dzul@uneatlantico.es,
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