Documentos donde el Autor es "Elexpuru Zabaleta, Maria"

2024

Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Producción Científica Abierto Inglés In the last decades, the world population and demand for any kind of product have grown exponentially. The rhythm of production to satisfy the request of the population has become unsustainable and the concept of the linear economy, introduced after the Industrial Revolution, has been replaced by a new economic approach, the circular economy. In this new economic model, the concept of “the end of life” is substituted by the concept of restoration, providing a new life to many industrial wastes. Leaves are a by-product of several agricultural cultivations. In recent years, the scientific interest regarding leaf biochemical composition grew, recording that plant leaves may be considered an alternative source of bioactive substances. Plant leaves’ main bioactive compounds are similar to those in fruits, i.e., phenolic acids and esters, flavonols, anthocyanins, and procyanidins. Bioactive compounds can positively influence human health; in fact, it is no coincidence that the leaves were used by our ancestors as a natural remedy for various pathological conditions. Therefore, leaves can be exploited to manufacture many products in food (e.g., being incorporated in food formulations as natural antioxidants, or used to create edible coatings or films for food packaging), cosmetic and pharmaceutical industries (e.g., promising ingredients in anti-aging cosmetics such as oils, serums, dermatological creams, bath gels, and other products). This review focuses on the leaves’ main bioactive compounds and their beneficial health effects, indicating their applications until today to enhance them as a harvesting by-product and highlight their possible reuse for new potential healthy products. metadata Regolo, Lucia; Giampieri, Francesca; Battino, Maurizio; Armas Diaz, Yasmany; Mezzetti, Bruno; Elexpuru Zabaleta, Maria; Mazas Pérez-Oleaga, Cristina; Tutusaus, Kilian y Mazzoni, Luca mail SIN ESPECIFICAR, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, maria.elexpuru@uneatlantico.es, cristina.mazas@uneatlantico.es, kilian.tutusaus@uneatlantico.es, SIN ESPECIFICAR (2024) From by-products to new application opportunities: the enhancement of the leaves deriving from the fruit plants for new potential healthy products. Frontiers in Nutrition, 11. ISSN 2296-861X

Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Producción Científica Abierto Inglés Much of nutrition research has been conventionally based on the use of simplistic in vitro systems or animal models, which have been extensively employed in an effort to better understand the relationships between diet and complex diseases as well as to evaluate food safety. Although these models have undeniably contributed to increase our mechanistic understanding of basic biological processes, they do not adequately model complex human physiopathological phenomena, creating concerns about the translatability to humans. During the last decade, extraordinary advancement in stem cell culturing, three-dimensional cell cultures, sequencing technologies, and computer science has occurred, which has originated a wealth of novel human-based and more physiologically relevant tools. These tools, also known as “new approach methodologies,” which comprise patient-derived organoids, organs-on-chip, multi-omics approach, along with computational models and analysis, represent innovative and exciting tools to forward nutrition research from a human-biology-oriented perspective. After considering some shortcomings of conventional in vitro and vivo approaches, here we describe the main novel available and emerging tools that are appropriate for designing a more human-relevant nutrition research. Our aim is to encourage discussion on the opportunity to explore innovative paths in nutrition research and to promote a paradigm-change toward a more human biology-focused approach to better understand human nutritional pathophysiology, to evaluate novel food products, and to develop more effective targeted preventive or therapeutic strategies while helping in reducing the number and replacing animals employed in nutrition research. metadata Cassotta, Manuela; Cianciosi, Danila; Elexpuru Zabaleta, Maria; Elío Pascual, Iñaki; Sumalla Cano, Sandra; Giampieri, Francesca y Battino, Maurizio mail manucassotta@gmail.com, SIN ESPECIFICAR, maria.elexpuru@uneatlantico.es, inaki.elio@uneatlantico.es, sandra.sumalla@uneatlantico.es, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es (2024) Human‐based new approach methodologies to accelerate advances in nutrition research. Food Frontiers. pp. 1-32. ISSN 2643-8429

2023

Artículo Materias > Biomedicina
Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros Abierto Inglés The genus Aeromonas has received constant attention in different areas, from aquaculture and veterinary medicine to food safety, where more and more frequent isolates are occurring with increased resistance to antibiotics. The present paper studied the interaction of Aeromonas strains isolated from fresh produce and water with different eukaryotic cell types with the aim of better understanding the cytotoxic capacity of these strains. To study host-cell pathogen interactions in Aeromonas, we used HT-29, Vero, J774A.1, and primary mouse embryonic fibroblasts. These interactions were analyzed by confocal microscopy to determine the cytotoxicity of the strains. We also used Galleria mellonella larvae to test their pathogenicity in this experimental model. Our results demonstrated that two strains showed high cytotoxicity in epithelial cells, fibroblasts, and macrophages. Furthermore, these strains showed high virulence using the G. mellonella model. All strains used in this paper generally showed low levels of resistance to the different families of the antibiotics being tested. These results indicated that some strains of Aeromonas present in vegetables and water pose a potential health hazard, displaying very high in vitro and in vivo virulence. This pathogenic potential, and some recent concerning findings on antimicrobial resistance in Aeromonas, encourage further efforts in examining the precise significance of Aeromonas strains isolated from foods for human consumption. metadata Pintor-Cora, Alberto; Tapia Martínez, Olga; Elexpuru Zabaleta, Maria; Ruiz de Alegría, Carlos; Rodríguez-Calleja, Jose M.; Santos, Jesús A. y Ramos Vivas, Jose mail SIN ESPECIFICAR, olga.tapia@uneatlantico.es, maria.elexpuru@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, jose.ramos@uneatlantico.es (2023) Cytotoxicity and Antimicrobial Resistance of Aeromonas Strains Isolated from Fresh Produce and Irrigation Water. Antibiotics, 12 (3). p. 511. ISSN 2079-6382

2022

Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros Abierto Inglés Hafnia alvei is receiving increasing attention from both a medical and veterinary point of view, but the diversity of molecules it produces has made the interest in this bacterium extend to the field of probiotics, the microbiota, and above all, to its presence and action on consumer foods. The production of Acyl Homoserine Lactones (AHLs), a type of quorum-sensing (QS) signaling molecule, is the most often-studied chemical signaling molecule in Gram-negative bacteria. H. alvei can use this communication mechanism to promote the expression of certain enzymatic activities in fermented foods, where this bacterium is frequently present. H. alvei also produces a series of molecules involved in the modification of the organoleptic properties of different products, especially cheeses, where it shares space with other microorganisms. Although some strains of this species are implicated in infections in humans, many produce antibacterial compounds, such as bacteriocins, that inhibit the growth of true pathogens, so the characterization of these molecules could be very interesting from the point of view of clinical medicine and the food industry. Lastly, in some cases, H. alvei is responsible for the production of biogenic amines or other compounds of special interest in food health. In this article, we will review the most interesting molecules that produce the H. alvei strains and will discuss some of their properties, both from the point of view of their biological activity on other microorganisms and the properties of different food matrices in which this bacterium usually thrives. metadata Ramos Vivas, Jose; Tapia Martínez, Olga; Elexpuru Zabaleta, Maria; Tutusaus, Kilian; Armas Diaz, Yasmany; Battino, Maurizio y Giampieri, Francesca mail jose.ramos@uneatlantico.es, olga.tapia@uneatlantico.es, maria.elexpuru@uneatlantico.es, kilian.tutusaus@uneatlantico.es, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es, francesca.giampieri@uneatlantico.es (2022) The Molecular Weaponry Produced by the Bacterium Hafnia alvei in Foods. Molecules, 27 (17). p. 5585. ISSN 1420-3049

Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros Abierto Inglés The aim of this study was to evaluate the influence of the lockdown due to the COVID-19 pandemic, on eating and physical activity behavior, in a university population. A healthy diet such as the Mediterranean Diet (MD) pattern, rich in fruit and vegetables, can prevent degenerative diseases such as obesity, diabetes, cardiovascular diseases, etc. We conducted a cross-sectional study and data were collected by an anonymous online questionnaire. Participants completed a survey consisting of 3 sections: sociodemographic data; dietary behavior and physical activity; the Mediterranean Diet questionnaire (MEDAS-14) and the Emotional Eater Questionnaire (EEQ). A total of 168 participants completed the questionnaire: 66.7% were women, 79.2% were from Spain, 76.8% were students, 76.2% lived in their family home and 66.1% were of normal weight. During lockdown our population shopped for groceries 1 time or less per week (76.8%); maintained the same consumption of fruits (45.2%), vegetables (50.6%), dairy products (61.9%), pulses (64.9%), fish/seafood (57.7%), white meat (77.4%), red and processed meat (71.4%), pastries and snacks (48.2%), rice/pasta/potatoes (70.2%) and nuts (62.5%), spirits (98.8%) and sugary drinks (91.7%). Cooking time increased (73.2%) and the consumption decreased of low alcohol drinks (60.1%), spirits (75%) and sugary drinks (57.1%), and physical activity also diminished (49.4%). University Employees (UE) gained more weight (1.01 ± 0.02) than students (0.99 ± 0.03) (p < 0.05) during the confinement period. A total of 79.8% of the participants obtained a Medium/High Adherence to the MD during lockdown. Emotional and very emotional eaters were higher in the female group (p < 0.01). In the event of further confinement, strategies should be implemented to promote a balanced and healthy diet together with the practice of physical activity, taking special care of the female and UE groups. metadata Sumalla Cano, Sandra; Forbes-Hernández, Tamara; Aparicio-Obregón, Silvia; Crespo-Álvarez, Jorge; Elexpuru Zabaleta, Maria; Gracia Villar, Mónica; Giampieri, Francesca y Elío Pascual, Iñaki mail sandra.sumalla@uneatlantico.es, SIN ESPECIFICAR, silvia.aparicio@uneatlantico.es, jorge.crespo@uneatlantico.es, maria.elexpuru@uneatlantico.es, monica.gracia@uneatlantico.es, francesca.giampieri@uneatlantico.es, inaki.elio@uneatlantico.es (2022) Changes in the Lifestyle of the Spanish University Population during Confinement for COVID-19. International Journal of Environmental Research and Public Health, 19 (4). p. 2210. ISSN 1660-4601

2021

Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Producción Científica Cerrado Inglés Fasting, caloric restriction and foods or compounds mimicking the biological effects of caloric restriction, known as caloric restriction mimetics, have been associated with a lower risk of age-related diseases, including cardiovascular diseases, cancer and cognitive decline, and a longer lifespan. Reduced calorie intake has been shown to stimulate cancer immunosurveillance, reducing the migration of immunosuppressive regulatory T cells towards the tumor bulk. Autophagy stimulation via reduction of lysine acetylation, increased sensitivity to chemo- and immunotherapy, along with a reduction of insulin-like growth factor 1 and reactive oxygen species have been described as some of the major effects triggered by caloric restriction. Fasting and caloric restriction have also been shown to beneficially influence gut microbiota composition, modify host metabolism, reduce total cholesterol and triglyceride levels, lower diastolic blood pressure and elevate morning cortisol level, with beneficial modulatory effects on cardiopulmonary fitness, body fat and weight, fatigue and weakness, and general quality of life. Moreover, caloric restriction may reduce the carcinogenic and metastatic potential of cancer stem cells, which are generally considered responsible of tumor formation and relapse. Here, we reviewed in vitro and in vivo studies describing the effects of fasting, caloric restriction and some caloric restriction mimetics on immunosurveillance, gut microbiota, metabolism, and cancer stem cell growth, highlighting the molecular and cellular mechanisms underlying these effects. Additionally, studies on caloric restriction interventions in cancer patients or cancer risk subjects are discussed. Considering the promising effects associated with caloric restriction and caloric restriction mimetics, we think that controlled-randomized large clinical trials are warranted to evaluate the inclusion of these non-pharmacological approaches in clinical practice. metadata Pistollato, Francesca; Forbes-Hernández, Tamara Y.; Calderón Iglesias, Rubén; Ruiz Salces, Roberto; Elexpuru Zabaleta, Maria; Dominguez Azpíroz, Irma; Cianciosi, Danila; Quiles, José L.; Giampieri, Francesca y Battino, Maurizio mail francesca.pistollato@uneatlantico.es, SIN ESPECIFICAR, ruben.calderon@uneatlantico.es, roberto.ruiz@uneatlantico.es, maria.elexpuru@uneatlantico.es, irma.dominguez@unini.edu.mx, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR (2021) Effects of caloric restriction on immunosurveillance, microbiota and cancer cell phenotype: Possible implications for cancer treatment. Seminars in Cancer Biology. pp. 45-57. ISSN 1044-579X

Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros Abierto Inglés Presently, biopreservation through protective bacterial cultures and their antimicrobial products or using antibacterial compounds derived from plants are proposed as feasible strategies to maintain the long shelf-life of products. Another emerging category of food biopreservatives are bacteriophages or their antibacterial enzymes called “phage lysins” or “enzybiotics”, which can be used directly as antibacterial agents due to their ability to act on the membranes of bacteria and destroy them. Bacteriophages are an alternative to antimicrobials in the fight against bacteria, mainly because they have a practically unique host range that gives them great specificity. In addition to their potential ability to specifically control strains of pathogenic bacteria, their use does not generate a negative environmental impact as in the case of antibiotics. Both phages and their enzymes can favor a reduction in antibiotic use, which is desirable given the alarming increase in resistance to antibiotics used not only in human medicine but also in veterinary medicine, agriculture, and in general all processes of manufacturing, preservation, and distribution of food. We present here an overview of the scientific background of phages and enzybiotics in the food industry, as well as food applications of these biopreservatives. metadata Ramos Vivas, Jose; Elexpuru Zabaleta, Maria; Sámano Celorio, María Luisa; Pascual Barrera, Alina Eugenia; Forbes-Hernandez, Tamara Y.; Giampieri, Francesca y Battino, Maurizio mail jose.ramos@uneatlantico.es, maria.elexpuru@uneatlantico.es, marialuisa.samano@uneatlantico.es, alina.pascual@unini.edu.mx, tamara.forbes@unini.edu.mx, SIN ESPECIFICAR, SIN ESPECIFICAR (2021) Phages and Enzybiotics in Food Biopreservation. Molecules, 26 (17). p. 5138. ISSN 1420-3049

Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros Cerrado Inglés BACKGROUND:In Spain, there are several studies published on the relationship between eating habits and lifestyle among university students; but only a few of them are focused on online postgraduate students. OBJECTIVE:Herein we aimed to evaluate the degree of adherence to the Mediterranean diet pyramid (2010 edition), non-communicable diseases (NCDs), and lifestyle in online postgraduate students aged 20–65 years belonging to the food area of the Fundación Universitaria Iberoamericana (FUNIBER). METHODS:We performed a descriptive cross-sectional study including 100 online post-graduate students aged 20–65 years who were recruited by an accidental non-probabilistic sampling method consisting of a questionnaire on their sociodemographic characteristics, NCDs, lifestyle, and a 3-day food intake record (3-d). RESULTS:The profile of the students was 74% women, with a mean age of 36.6 (±10.5) years and body mass index (BMI) of 22.6 kg / m2 (±3.3). 71% of the volunteers presented normal weight, while 20% were overweight. Indeed, only a low percentage of the volunteers presented hypertension (1%), cardiovascular disease (0%), diabetes mellitus 1 (2%), diabetes mellitus 2 (3%), hypercholesterolemia (9%), and hyperuricemia (2%). Concerning lifestyle, (77%) of students were non-smokers, (78%) consumed beverages with caffeine, (51%) did not consume alcoholic beverages, and nearly all of them (84%) frequently (3 times /week) practiced physical activity. 68% of the recruited students exhibited adherence to “Medium diet quality diet (4–7)” followed by (26%) with a “Poor diet quality (<3)” and “Optimal diet quality” (6%). CONCLUSIONS:Spanish postgraduate students of the nutritional area, have good health and a healthy lifestyle but are moving away from the MD model, should be established campaigns for the improvement of eating habits of the postgraduate university population. metadata Elío Pascual, Iñaki; Jarrin, Sandra; Elexpuru Zabaleta, Maria; Crespo-Álvarez, Jorge; Dominguez Azpíroz, Irma; Tutusaus, Kilian; Ruiz Salces, Roberto; Calderón Iglesias, Rubén y Sumalla Cano, Sandra mail inaki.elio@uneatlantico.es, sandra.jarrin@uneatlantico.es, maria.elexpuru@uneatlantico.es, jorge.crespo@uneatlantico.es, irma.dominguez@uneatlantico.es, kilian.tutusaus@uneatlantico.es, roberto.ruiz@uneatlantico.es, ruben.calderon@uneatlantico.es, sandra.sumalla@uneatlantico.es (2021) Adherence to the pyramid of the Mediterranean diet (2010), non-communicable diseases and lifestyle in online postgraduate Spanish students in the food area. Mediterranean Journal of Nutrition and Metabolism, 14 (2). pp. 191-205. ISSN 1973798X