Documentos donde el Autor es "Mazas Pérez-Oleaga, Cristina"

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Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Producción Científica
Universidad de La Romana > Investigación > Producción Científica
Abierto Inglés The evolution of the COVID-19 pandemic has been associated with variations in clinical presentation and severity. Similarly, prediction scores may suffer changes in their diagnostic accuracy. The aim of this study was to test the 30-day mortality predictive validity of the 4C and SEIMC scores during the sixth wave of the pandemic and to compare them with those of validation studies. This was a longitudinal retrospective observational study. COVID-19 patients who were admitted to the Emergency Department of a Spanish hospital from December 15, 2021, to January 31, 2022, were selected. A side-by-side comparison with the pivotal validation studies was subsequently performed. The main measures were 30-day mortality and the 4C and SEIMC scores. A total of 27,614 patients were considered in the study, including 22,361 from the 4C, 4,627 from the SEIMC and 626 from our hospital. The 30-day mortality rate was significantly lower than that reported in the validation studies. The AUCs were 0.931 (95% CI: 0.90–0.95) for 4C and 0.903 (95% CI: 086–0.93) for SEIMC, which were significantly greater than those obtained in the first wave. Despite the changes that have occurred during the coronavirus disease 2019 (COVID-19) pandemic, with a reduction in lethality, scorecard systems are currently still useful tools for detecting patients with poor disease risk, with better prognostic capacity. metadata de Santos Castro, Pedro Ángel; del Pozo Vegas, Carlos; Pinilla Arribas, Leyre Teresa; Zalama Sánchez, Daniel; Sanz-García, Ancor; Vásquez del Águila, Tony Giancarlo; González Izquierdo, Pablo; de Santos Sánchez, Sara; Mazas Pérez-Oleaga, Cristina; Dominguez Azpíroz, Irma; Elío Pascual, Iñaki y Martín-Rodríguez, Francisco mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, cristina.mazas@uneatlantico.es, irma.dominguez@unini.edu.mx, inaki.elio@uneatlantico.es, SIN ESPECIFICAR (2024) Performance of the 4C and SEIMC scoring systems in predicting mortality from onset to current COVID-19 pandemic in emergency departments. Scientific Reports, 14 (1). ISSN 2045-2322

Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Producción Científica
Universidad de La Romana > Investigación > Producción Científica
Abierto Inglés The evolution of the COVID-19 pandemic has been associated with variations in clinical presentation and severity. Similarly, prediction scores may suffer changes in their diagnostic accuracy. The aim of this study was to test the 30-day mortality predictive validity of the 4C and SEIMC scores during the sixth wave of the pandemic and to compare them with those of validation studies. This was a longitudinal retrospective observational study. COVID-19 patients who were admitted to the Emergency Department of a Spanish hospital from December 15, 2021, to January 31, 2022, were selected. A side-by-side comparison with the pivotal validation studies was subsequently performed. The main measures were 30-day mortality and the 4C and SEIMC scores. A total of 27,614 patients were considered in the study, including 22,361 from the 4C, 4,627 from the SEIMC and 626 from our hospital. The 30-day mortality rate was significantly lower than that reported in the validation studies. The AUCs were 0.931 (95% CI: 0.90–0.95) for 4C and 0.903 (95% CI: 086–0.93) for SEIMC, which were significantly greater than those obtained in the first wave. Despite the changes that have occurred during the coronavirus disease 2019 (COVID-19) pandemic, with a reduction in lethality, scorecard systems are currently still useful tools for detecting patients with poor disease risk, with better prognostic capacity. metadata de Santos Castro, Pedro Ángel; del Pozo Vegas, Carlos; Pinilla Arribas, Leyre Teresa; Zalama Sánchez, Daniel; Sanz-García, Ancor; Vásquez del Águila, Tony Giancarlo; González Izquierdo, Pablo; de Santos Sánchez, Sara; Mazas Pérez-Oleaga, Cristina; Dominguez Azpíroz, Irma; Elío Pascual, Iñaki y Martín-Rodríguez, Francisco mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, cristina.mazas@uneatlantico.es, irma.dominguez@unini.edu.mx, inaki.elio@uneatlantico.es, SIN ESPECIFICAR (2024) Performance of the 4C and SEIMC scoring systems in predicting mortality from onset to current COVID-19 pandemic in emergency departments. Scientific Reports, 14 (1). ISSN 2045-2322

Artículo Materias > Biomedicina
Materias > Ciencias Sociales
Materias > Ingeniería
Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Producción Científica
Universidad de La Romana > Investigación > Producción Científica
Abierto Inglés Aim: The development of predictive models for patients treated by emergency medical services (EMS) is on the rise in the emergency field. However, how these models evolve over time has not been studied. The objective of the present work is to compare the characteristics of patients who present mortality in the short, medium and long term, and to derive and validate a predictive model for each mortality time. Methods: A prospective multicenter study was conducted, which included adult patients with unselected acute illness who were treated by EMS. The primary outcome was noncumulative mortality from all causes by time windows including 30-day mortality, 31- to 180-day mortality, and 181- to 365-day mortality. Prehospital predictors included demographic variables, standard vital signs, prehospital laboratory tests, and comorbidities. Results: A total of 4830 patients were enrolled. The noncumulative mortalities at 30, 180, and 365 days were 10.8%, 6.6%, and 3.5%, respectively. The best predictive value was shown for 30-day mortality (AUC = 0.930; 95% CI: 0.919–0.940), followed by 180-day (AUC = 0.852; 95% CI: 0.832–0.871) and 365-day (AUC = 0.806; 95% CI: 0.778–0.833) mortality. Discussion: Rapid characterization of patients at risk of short-, medium-, or long-term mortality could help EMS to improve the treatment of patients suffering from acute illnesses. metadata Enriquez de Salamanca Gambara, Rodrigo; Sanz-García, Ancor; del Pozo Vegas, Carlos; López-Izquierdo, Raúl; Sánchez Soberón, Irene; Delgado Benito, Juan F.; Martínez Díaz, Raquel; Mazas Pérez-Oleaga, Cristina; Martínez López, Nohora Milena; Dominguez Azpíroz, Irma y Martín-Rodríguez, Francisco mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, raquel.martinez@uneatlantico.es, cristina.mazas@uneatlantico.es, nohora.martinez@uneatlantico.es, irma.dominguez@unini.edu.mx, SIN ESPECIFICAR (2024) A Comparison of the Clinical Characteristics of Short-, Mid-, and Long-Term Mortality in Patients Attended by the Emergency Medical Services: An Observational Study. Diagnostics, 14 (12). p. 1292. ISSN 2075-4418

Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Producción Científica
Abierto Inglés In the last decades, the world population and demand for any kind of product have grown exponentially. The rhythm of production to satisfy the request of the population has become unsustainable and the concept of the linear economy, introduced after the Industrial Revolution, has been replaced by a new economic approach, the circular economy. In this new economic model, the concept of “the end of life” is substituted by the concept of restoration, providing a new life to many industrial wastes. Leaves are a by-product of several agricultural cultivations. In recent years, the scientific interest regarding leaf biochemical composition grew, recording that plant leaves may be considered an alternative source of bioactive substances. Plant leaves’ main bioactive compounds are similar to those in fruits, i.e., phenolic acids and esters, flavonols, anthocyanins, and procyanidins. Bioactive compounds can positively influence human health; in fact, it is no coincidence that the leaves were used by our ancestors as a natural remedy for various pathological conditions. Therefore, leaves can be exploited to manufacture many products in food (e.g., being incorporated in food formulations as natural antioxidants, or used to create edible coatings or films for food packaging), cosmetic and pharmaceutical industries (e.g., promising ingredients in anti-aging cosmetics such as oils, serums, dermatological creams, bath gels, and other products). This review focuses on the leaves’ main bioactive compounds and their beneficial health effects, indicating their applications until today to enhance them as a harvesting by-product and highlight their possible reuse for new potential healthy products. metadata Regolo, Lucia; Giampieri, Francesca; Battino, Maurizio; Armas Diaz, Yasmany; Mezzetti, Bruno; Elexpuru Zabaleta, Maria; Mazas Pérez-Oleaga, Cristina; Tutusaus, Kilian y Mazzoni, Luca mail SIN ESPECIFICAR, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, maria.elexpuru@uneatlantico.es, cristina.mazas@uneatlantico.es, kilian.tutusaus@uneatlantico.es, SIN ESPECIFICAR (2024) From by-products to new application opportunities: the enhancement of the leaves deriving from the fruit plants for new potential healthy products. Frontiers in Nutrition, 11. ISSN 2296-861X

Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Producción Científica
Universidad de La Romana > Investigación > Producción Científica
Abierto Inglés Objective The aim was to explore the association of demographic and prehospital parameters with short-term and long-term mortality in acute life-threatening cardiovascular disease by using a hazard model, focusing on elderly individuals, by comparing patients under 75 years versus patients over 75 years of age. Design Prospective, multicentre, observational study. Setting Emergency medical services (EMS) delivery study gathering data from two back-to-back studies between 1 October 2019 and 30 November 2021. Six advanced life support (ALS), 43 basic life support and five hospitals in Spain were considered. Participants Adult patients suffering from acute life-threatening cardiovascular disease attended by the EMS. Primary and secondary outcome measures The primary outcome was in-hospital mortality from any cause within the first to the 365 days following EMS attendance. The main measures included prehospital demographics, biochemical variables, prehospital ALS techniques used and syndromic suspected conditions. Results A total of 1744 patients fulfilled the inclusion criteria. The 365-day cumulative mortality in the elderly amounted to 26.1% (229 cases) versus 11.6% (11.6%) in patients under 75 years old. Elderly patients (≥75 years) presented a twofold risk of mortality compared with patients ≤74 years. Life-threatening interventions (mechanical ventilation, cardioversion and defibrillation) were also related to a twofold increased risk of mortality. Importantly, patients suffering from acute heart failure presented a more than twofold increased risk of mortality. Conclusions This study revealed the prehospital variables associated with the long-term mortality of patients suffering from acute cardiovascular disease. Our results provide important insights for the development of specific codes or scores for cardiovascular diseases to facilitate the risk of mortality characterisation. metadata del Pozo Vegas, Carlos; Zalama-Sánchez, Daniel; Sanz-Garcia, Ancor; López-Izquierdo, Raúl; Sáez-Belloso, Silvia; Mazas Pérez-Oleaga, Cristina; Dominguez Azpíroz, Irma; Elío Pascual, Iñaki y Martín-Rodríguez, Francisco mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, cristina.mazas@uneatlantico.es, irma.dominguez@unini.edu.mx, inaki.elio@uneatlantico.es, SIN ESPECIFICAR (2023) Prehospital acute life-threatening cardiovascular disease in elderly: an observational, prospective, multicentre, ambulance-based cohort study. BMJ Open, 13 (11). e078815. ISSN 2044-6055

Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Producción Científica
Abierto Inglés Background: Nowadays, there is no gold standard score for prehospital sepsis and sepsis-related mortality identification. The aim of the present study was to analyze the performance of qSOFA, NEWS2 and mSOFA as sepsis predictors in patients with infection-suspected in prehospital care. The second objective is to study the predictive ability of the aforementioned scores in septic-shock and in-hospital mortality. Methods: Prospective, ambulance-based, and multicenter cohort study, developed by the emergency medical services, among patients (n = 535) with suspected infection transferred by ambulance with high-priority to the emergency department (ED). The study enrolled 40 ambulances and 4 ED in Spain between 1 January 2020, and 30 September 2021. All the variables used in the scores, in addition to socio-demographic data, standard vital signs, prehospital analytical parameters (glucose, lactate, and creatinine) were collected. For the evaluation of the scores, the discriminative power, calibration curve and decision curve analysis (DCA) were used. Results: The mSOFA outperformed the other two scores for mortality, presenting the following AUCs: 0.877 (95%CI 0.841–0.913), 0.761 (95%CI 0.706–0.816), 0.731 (95%CI 0.674–0.788), for mSOFA, NEWS, and qSOFA, respectively. No differences were found for sepsis nor septic shock, but mSOFA’s AUCs was higher than the one of the other two scores. The calibration curve and DCA presented similar results. Conclusion: The use of mSOFA could provide and extra insight regarding the short-term mortality and sepsis diagnostic, backing its recommendation in the prehospital scenario. metadata Melero-Guijarro, Laura; Sanz-García, Ancor; Martín-Rodríguez, Francisco; Lipari, Vivian; Mazas Pérez-Oleaga, Cristina; Carvajal-Altamiranda, Stefanía; Martínez López, Nohora Milena; Dominguez Azpíroz, Irma; Castro Villamor, Miguel A.; Sánchez Soberón, Irene y López-Izquierdo, Raúl mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, vivian.lipari@uneatlantico.es, cristina.mazas@uneatlantico.es, stefania.carvajal@uneatlantico.es, nohora.martinez@uneatlantico.es, irma.dominguez@unini.edu.mx, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR (2023) Prehospital qSOFA, mSOFA, and NEWS2 performance for sepsis prediction: A prospective, multi-center, cohort study. Frontiers in Medicine, 10. ISSN 2296-858X

Artículo Materias > Ingeniería Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Docencia > Trabajos finales de grado
Abierto Inglés Power Quality (PQ) has become a significant issue in power networks. Power quality disturbances must be precisely and appropriately identified. This activity involves identifying, classifying, and mitigating power quality problems. A case study of the Awada industrial zone in Ethiopia is taken into consideration to show the practical applicability of the proposed work. It is found that the current harmonic distortion levels exceed the restrictions with a maximum percentage Total Harmonic Distortion of Current (THDI) value of up to 23.09%. The signal processing technique, i.e., Stockwell Transform (ST) is utilized for the identification of power quality issues, and it covers the most important and common power quality issues. The Support Vector Machine (SVM) method is used to categorize power quality issues, which enhances the classification procedure. The ST scored better in terms of accuracy than the Wavelet Transform (WT), Fourier Transform (FT), and Hilbert Transform (HT), obtaining 97.1%, as compared to 91.08%, 88.91%, and 86.8%, respectively. The maximum classification accuracy of SVM was 98.3%. To lower the current level of harmonic distortion in the industrial sector, a Distribution Static Compensator (D-STATCOM) is developed in the current control mode. To evaluate the performance of the D-STATCOM, the performance of the distribution network with and without D-STATCOM is simulated. The simulation results show that THDI is reduced to 4.36% when the suggested D-STATCOM is applied in the system. metadata Mengistu, Epaphros; Khan, Baseem; Qasaymeh, Yazeed; Alghamdi, Ali S.; Zubair, Muhammad; Awan, Ahmed Bilal; Ashiq, Muhammad Gul Bahar; Ali, Samia Gharib y Mazas Pérez-Oleaga, Cristina mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, cristina.mazas@uneatlantico.es (2023) Utilization of Stockwell Transform, Support Vector Machine and D-STATCOM for the Identification, Classification and Mitigation of Power Quality Problems. Sustainability, 15 (7). p. 6007. ISSN 2071-1050

Artículo Materias > Biomedicina
Materias > Alimentación
Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Producción Científica
Cerrado Inglés Cactus has been used in traditional folk medicine because of its role in treating a number of diseases and conditions. Prickly pear fruit is an excellent source of secondary metabolites (i.e., betalains, flavonoids, and ascorbic acid) with health-promoting properties against many common human diseases, including diabetes, hypertension, hypercholesterolemia, rheumatic pain, gastric mucosa diseases and asthma. In addition, prickly pears are potential candidates for the development of low-cost functional foods because they grow with low water requirements in arid regions of the world. This review describes the main bioactive compounds found in this fruit and shows the in vitro and some clinical studies about the fruit of most important cactus (Opuntia ficus-indica) and its relationship with some chronic diseases. Even though a lot of effort have been done to study the relationship between this fruit and the human health, more studies on Opuntia ficus-indica could help better understand its pharmacological mechanism of action to provide clear scientific evidence to explain its traditional uses, and to identify its therapeutic potential in other diseases. metadata Armas Diaz, Yasmany; Machì, Michele; Salinari, Alessia; Mazas Pérez-Oleaga, Cristina; Martínez López, Nohora Milena; Briones Urbano, Mercedes y Cianciosi, Danila mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, cristina.mazas@uneatlantico.es, nohora.martinez@uneatlantico.es, mercedes.briones@uneatlantico.es, SIN ESPECIFICAR (2022) Prickly pear fruits from "Opuntia ficus-indica" varieties as a source of potential bioactive compounds in the Mediterranean diet. Mediterranean Journal of Nutrition and Metabolism, 15 (4). pp. 581-592. ISSN 1973798X

Artículo Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Producción Científica
Abierto Inglés Rivers are dynamic geological agents on the earth which transport the weathered materials of the continent to the sea. Estimation of suspended sediment yield (SSY) is essential for management, planning, and designing in any river basin system. Estimation of SSY is critical due to its complex nonlinear processes, which are not captured by conventional regression methods. Rainfall, temperature, water discharge, SSY, rock type, relief, and catchment area data of 11 gauging stations were utilized to develop robust artificial intelligence (AI), similar to an artificial-neural-network (ANN)-based model for SSY prediction. The developed highly generalized global single ANN model using a large amount of data was applied at individual gauging stations for SSY prediction in the Mahanadi River basin, which is one of India’s largest peninsular rivers. It appeared that the proposed ANN model had the lowest root-mean-squared error (0.0089) and mean absolute error (0.0029) along with the highest coefficient of correlation (0.867) values among all comparative models (sediment rating curve and multiple linear regression). The ANN provided the best accuracy at Tikarapara among all stations. The ANN model was the most suitable substitute over other comparative models for SSY prediction. It was also noticed that the developed ANN model using the combined data of eleven stations performed better at Tikarapara than the other ANN which was developed using data from Tikarapara only. These approaches are suggested for SSY prediction in river basin systems due to their ease of implementation and better performance. metadata Yadav, Arvind; Chithaluru, Premkumar; Singh, Aman; Joshi, Devendra; Elkamchouchi, Dalia H.; Mazas Pérez-Oleaga, Cristina y Anand, Divya mail SIN ESPECIFICAR, SIN ESPECIFICAR, aman.singh@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, cristina.mazas@uneatlantico.es, divya.anand@uneatlantico.es (2022) An Enhanced Feed-Forward Back Propagation Levenberg–Marquardt Algorithm for Suspended Sediment Yield Modeling. Water, 14 (22). p. 3714. ISSN 2073-4441

Artículo Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Producción Científica
Abierto Inglés The world population is on the rise, which demands higher food production. The reduction in the amount of land under cultivation due to urbanization makes this more challenging. The solution to this problem lies in the artificial cultivation of crops. IoT and sensors play an important role in optimizing the artificial cultivation of crops. The selection of sensors is important in order to ensure a better quality and yield in an automated artificial environment. There are many challenges involved in selecting sensors due to the highly competitive market. This paper provides a novel approach to sensor selection for saffron cultivation in an IoT-based environment. The crop used in this study is saffron due to the reason that much less research has been conducted on its hydroponic cultivation using sensors and its huge economic impact. A detailed hardware-based framework, the growth cycle of the crop, along with all the sensors, and the block layout used for saffron cultivation in a hydroponic medium are provided. The important parameters for a hydroponic medium, such as the concentration of nutrients and flow rate required, are discussed in detail. This paper is the first of its kind to explain the sensor configurations, performance metrics, and sensor-based saffron cultivation model. The paper discusses different metrics related to the selection, use and role of sensors in different IoT-based saffron cultivation practices. A smart hydroponic setup for saffron cultivation is proposed. The results of the model are evaluated using the AquaCrop simulator. The simulator is used to evaluate the value of performance metrics such as the yield, harvest index, water productivity, and biomass. The values obtained provide better results as compared to natural cultivation. metadata Kour, Kanwalpreet; Gupta, Deepali; Gupta, Kamali; Anand, Divya; Elkamchouchi, Dalia H.; Mazas Pérez-Oleaga, Cristina; Ibrahim, Muhammad y Goyal, Nitin mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, divya.anand@uneatlantico.es, SIN ESPECIFICAR, cristina.mazas@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR (2022) Monitoring Ambient Parameters in the IoT Precision Agriculture Scenario: An Approach to Sensor Selection and Hydroponic Saffron Cultivation. Sensors, 22 (22). p. 8905. ISSN 1424-8220

Artículo Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Producción Científica
Abierto Inglés β-Thalassemia is one of the dangerous causes of the high mortality rate in the Mediterranean countries. Substantial resources are required to save a β-Thalassemia carriers’ life and early detection of thalassemia patients can help appropriate treatment to increase the carrier’s life expectancy. Being a genetic disease, it can not be prevented however the analysis of several indicators in parents’ blood can be used to detect disorders causing Thalassemia. Laboratory tests for Thalassemia are time-consuming and expensive like high-performance liquid chromatography, Complete Blood Count (CBC) with peripheral smear, genetic test, etc. Red blood indices from CBC can be used with machine learning models for the same task. Despite the available approaches for Thalassemia carriers from CBC data, gaps exist between the desired and achieved accuracy. Moreover, the data imbalance problem is studied well which makes the models less generalizable. This study proposes a highly accurate approach for β-Thalassemia detection using red blood indices from CBC augmented by supervised machine learning. In view of the fact that all the features do not carry predictive information regarding the target variable, this study employs a unified framework of two features selection techniques including Principal Component Analysis (PCA) and Singular Vector Decomposition (SVD). The data imbalance between β-Thalassemia carrier and non-carriers is handled by Synthetic Minority Oversampling Technique (SMOTE) and Adaptive Synthetic (ADASYN). Extensive experiments are performed using many state-of-the-art machine learning models and deep learning models. Experimental results indicate the superiority of the proposed approach over existing approaches with an accuracy score of 0.96. metadata Rustam, Furqan; Ashraf, Imran; Jabbar, Shehbaz; Tutusaus, Kilian; Mazas Pérez-Oleaga, Cristina; Pascual Barrera, Alina Eugenia y de la Torre Diez, Isabel mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, kilian.tutusaus@uneatlantico.es, cristina.mazas@uneatlantico.es, alina.pascual@unini.edu.mx, SIN ESPECIFICAR (2022) Prediction β-Thalassemia carriers using complete blood count features. Scientific Reports, 12 (1). ISSN 2045-2322

Artículo Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Producción Científica
Abierto Inglés Traditional optimization of open pit mine design is a crucial component of mining endeavors and is influenced by many variables. The critical factor in optimization is the geological uncertainty, which relates to the ore grade. To deal with uncertainties related to the block economic values of mining blocks and the general problem of mine design optimization, under unknown conditions, the best ultimate pit limits and pushback designs are produced by a minimum cut algorithm. The push–relabel minimal cut algorithm provides a framework for computationally efficient representation and processing of the economic values of mining blocks under multiple scenarios. A sequential Gaussian simulation-based smoothing spline technique was created. To produce pushbacks, an efficient parameterized minimum cut algorithm is suggested. An analysis of Indian iron ore mining was performed. The developed mine scheduling algorithm was compared with the conventional algorithm, and the results show that when uncertainty is considered, the cumulative metal production is higher and there is an additional increase of about 5% in net present value. The results of this work help the mining industry to plan mines in such a way that can generate maximum profit from the deposits. metadata Joshi, Devendra; Chithaluru, Premkumar; Singh, Aman; Yadav, Arvind; Elkamchouchi, Dalia H.; Mazas Pérez-Oleaga, Cristina y Anand, Divya mail SIN ESPECIFICAR, SIN ESPECIFICAR, aman.singh@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, cristina.mazas@uneatlantico.es, divya.anand@uneatlantico.es (2022) A Novel Large-Scale Stochastic Pushback Design Merged with a Minimum Cut Algorithm for Open Pit Mine Production Scheduling. Systems, 10 (5). p. 159. ISSN 2079-8954

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Association between socioeconomic and health variables and community-acquired pneumonia mortality rates in Chile from 1990 to 2021

Objectives To describe long-term trends in mortality attributed to community-acquired pneumonia (CAP) in Chile from 1990 to 2021, stratified by age group, and to evaluate associations with selected socioeconomic and demographic indicators. Study design Ecological, observational, longitudinal study using national secondary data. Methods CAP mortality rates were analyzed for the total population and by age group. Associations with the Human Development Index (HDI), poverty rate, aging index, and life expectancy at birth were examined using a hierarchical analytical approach. This included Spearman's rank correlation for initial exploration, multivariable linear regression to assess adjusted associations, and Prais–Winsten generalized least squares regression to account for first-order autocorrelation and shared temporal trends. Stationarity was evaluated using augmented Dickey–Fuller tests, with supplementary analyses using first-differenced variables. Missing data were imputed using time-based regression or interpolation, with sensitivity analyses performed. Results CAP mortality declined substantially across all age groups over the study period. Strong bivariate correlations were observed between mortality and all socioeconomic indicators; however, these associations were attenuated after adjustment for confounding and temporal autocorrelation. In multivariable and time-series models, HDI and the aging index remained significantly associated with CAP mortality in children (0–9 years) and older adults (≥65 years), whereas associations in intermediate age groups were not robust after accounting for shared secular trends. Poverty and life expectancy did not demonstrate independent associations in adjusted models. Conclusions CAP mortality in Chile has decreased markedly over the past three decades. Associations with socioeconomic indicators are strongest at the extremes of age and persist after accounting for temporal structure, although the ecological design precludes causal inference. These findings highlight the importance of considering demographic and socioeconomic context in population-level analyses of infectious disease outcomes.

Artículos y libros

Italo Salvador López Muñoz mail italo.lopez@doctorado.unini.edu.mx, Maria Loreto Romero Ladrón de Guevara mail , Christian R. Mejia mail , Shyla Del-Aguila-Arcentales mail , Aldo Alvarez-Risco mail , Neal M. Davies mail , Jaime A. Yáñez mail ,

López Muñoz

<a class="ep_document_link" href="/28577/1/PIIS0002944026001367.pdf"><img class="ep_doc_icon" alt="[img]" src="/style/images/fileicons/text.png" border="0"/></a>

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An Integrated Machine Learning and Genomic Framework for Precise Detection of Gastric Cancer

This study presents a novel integrative approach for the analysis of high-dimensional gene expression data, leveraging the complementary strengths of unsupervised clustering and supervised classification. Using K-means clustering, the dataset is stratified into three distinct clusters, revealing intrinsic biological patterns and relationships. The resulting cluster assignments are subsequently employed as pseudo-labels to train machine learning models, including support vector machines, random forest, and a stacking ensemble classifier. To validate and enhance the robustness of clustering, complementary methodologies such as hierarchical clustering and DBSCAN are employed, with results visualized through PCA-driven dimensionality reduction. The high predictive accuracy achieved by the classifiers underscores the separability and reliability of the identified clusters. Furthermore, feature importance analysis highlighted key genetic determinants within each cluster, offering actionable insights into potential biomarkers and critical genomic features. This framework bridges the gap between exploratory unsupervised learning and predictive supervised modeling, providing a scalable and interpretable methodology for analyzing complex genomic datasets. Its applicability extends to biomarker discovery, patient stratification, and other precision medicine applications, emphasizing its utility in advancing genomic research and clinical practice.

Producción Científica

Eshmal Iman mail , Sohail Jabbar mail , Shabana Ramzan mail , Ali Raza mail , Farwa Raoof mail , Stefanía Carvajal-Altamiranda mail stefania.carvajal@uneatlantico.es, Vivian Lipari mail vivian.lipari@uneatlantico.es, Imran Ashraf mail ,

Iman

<a href="/28319/1/s41598-026-45575-1_reference.pdf" class="ep_document_link"><img class="ep_doc_icon" alt="[img]" src="/style/images/fileicons/text.png" border="0"/></a>

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A novel approach for disease and pests detection in potato production system based on deep learning

Vulnerability of potato crops to diseases and pest infestation can affect its quality and lead to significant yield losses. Timely detection of such diseases can help take effective decisions. For this purpose, a deep learning-based object detection framework is designed in this study to identify and classify major potato diseases and pests under real-world field conditions. A total of 2,688 field images were collected from two research farms in Punjab, Pakistan, across multiple growth stages in various seasonal conditions. Excluding 285 symptoms-free images from the earliest collection led to 2,403 images which were annotated into four biotic-stress classes: blight disease (n = 630), leaf spot disease (n = 370), leafroll virus (viral symptom complex; n = 888), and Colorado potato beetle (larvae/adults; n = 515), indicating class imbalance. Several state-of-the-art models were used including YOLOv8 variants (n/s/m), YOLOv7, YOLOv5, and Faster R-CNN, and the results are discussed in relation to recent potato disease classification studies involving cropped leaf images. Stratified splitting (70% training, 20% validation, 10% testing) was applied to preserve class distribution across all subsets. YOLOv8-medium achieve the best performance with mean average precision (mAP)@0.5 of 98% on the held-out test images. Results for stable 5-fold cross-validation show a mean mAP@0.5 of 97.8%, which offers a balance between accuracy and inference time. Model robustness was evaluated using 5-fold cross-validation and repeated training with different random seeds, showing a low variance of ±0.4% mAP. Results demonstrate promising outcomes under the real-world field conditions, while, broader cross-region and cross-season validation is intended for the future.

Producción Científica

Ahmed Abbas mail , Saif Ur Rehman mail , Khalid Mahmood mail , Santos Gracia Villar mail santos.gracia@uneatlantico.es, Luis Alonso Dzul López mail luis.dzul@uneatlantico.es, Aseel Smerat mail , Imran Ashraf mail ,

Abbas

<a class="ep_document_link" href="/28320/1/1-s2.0-S1876034126000912-main.pdf"><img class="ep_doc_icon" alt="[img]" src="/style/images/fileicons/text.png" border="0"/></a>

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Concern for mpox infection in Latin America

Background Mpox arrived in Latin America and quickly began to replicate, so it is important to measure the concern it generates among residents. The study aims to assess whether country or other factors are associated with concern about mpox infection in Latin America. Methods The study uses a cross-sectional, multicenter design. Sampling was conducted using non-random snowball sampling. From August to September 2022, concern about being infected with mpox was assessed using a previously validated questionnaire (Cronbach's Alpha: 0.85); it was divided into nine countries and other social variables. Results From 1404 respondents, the majority of respondents were female (60.3%) and young (median age 25 years); also, a few reported that it was a significant problem (6% almost all the time and 11% often) and were concerned (6% almost all the time and 11% often) about the possibility of mpox infection. In multivariate analysis, men (aPR: 0.85; 95% CI: 0.73–0.99; p-value=0.046), younger (aPR: 0.98; 95% CI: 0.97–0.99; p-value<0.001), single (aPR: 0.78; 95% CI: 0.62–0.99; p-value=0.042) and, compared to Peru, those living in Colombia (aPR: 0.75; 95% CI. 0.58–0.97; p-value=0.027) and Costa Rica (aPR: 0.65; 95% CI: 0.44–0.96; p-value=0.032) reported the lowest concern; also, Bolivia (aPR: 1.16; 95% CI: 0.94–1.43; p-value=0.176) and Honduras (aPR: 1.01; 95% CI: 0.80–1.27; p-value=0.943) reported that their concerns tend to be higher. Conclusions There were evident differences across respondents' countries; these baseline results show that the first report was made in many countries that were also significantly affected by mpox and now face a new epidemic threatening public health.

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Christian R. Mejia mail , Aldo Alvarez-Risco mail , Luciana Daniela Garlisi-Torales mail , Telmo Raúl Aveiro mail , Jamil Cedillo-Balcázar mail , Néstor Valentin Rocha-Saravia mail , Andrea Retana-González mail , Medally C. Paucar mail , Beatriz Mejia Raudales mail , Jose Armada mail , Shyla Del-Aguila-Arcentales mail , Neal M. Davies mail , Jaime A. Yáñez mail jaime.yanez@unini.edu.mx,

Mejia

<a class="ep_document_link" href="/28323/1/s40520-026-03363-x_reference.pdf"><img class="ep_doc_icon" alt="[img]" src="/style/images/fileicons/text.png" border="0"/></a>

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Fish consumption and brain structure: a comprehensive systematic review of observational studies

Background Age-related structural changes in the human brain, including cortical atrophy, reductions in grey and white matter volumes, and the accumulation of small vessel–related lesions such as white matter hyperintensities (WMH) and cerebral microbleeds, represent critical biological substrates underlying cognitive decline and dementia. Fish consumption has been associated with slower cognitive decline and reduced risk of dementia, but a comprehensive evaluation of its relation with brain structures is lacking. Aims The aim of this study was to systematically review current scientific literature providing evidence of relation between fish intake and brain structures in human studies. Methods Studies indexed in two major electronic databases have been screened based on a combination of keywords and MeSH terms. Studies were eligible whether they assessed fish consumption in relation to brain structures in the adult populations. Results A total of 24 studies conducted predominantly on older adults met inclusion criteria. Most brain volume measures were obtained via magnetic resonance imaging (MRI) procedures. Higher fish consumption was associated with reduced severity of white matter hyperintensities (a biomarker of cerebral small vessel disease and white matter damage) and cerebral micro-bleed, preservation of certain brain areas volumes (i.e., hippocampus, temporal lobe and periventricle white matter) and cortical thickness of specific areas (i.e., precuneus, parietal, and cingulate grey matter), among others, compared to lower intake. Some analyses found no association and isolated findings suggested possible adverse associations that were not consistently replicated. Studies reporting null findings may underline the possible relevance of the overall diet (i.e., adherence to the Mediterranean diet). Conclusions Inclusion of fish in a healthy and balanced diet is associated with better white matter grades on MRI and slower progression of white matter hyperintensities and reduction of vascular-related lesions of the aging brain, suggesting a potential role in preventing neurocognitive deterioration. Heterogeneity across studies underscores the need for additional studies.

Producción Científica

Justyna Godos mail , Giuseppe Caruso mail , Agnieszka Micek mail , Alberto Dolci mail , Zoltan Ungvari mail , Andrea Lehoczki mail , Lisandra León Brizuela mail , Evelyn Frias-Toral mail , Andrea Di Mauro mail , Mario Siervo mail , Michelino Di Rosa mail , Giuseppe Grosso mail ,

Godos