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2023

Article Subjects > Biomedicine
Subjects > Engineering Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production Abierto Inglés In the last decade, artificial intelligence (AI) and AI-mediated technologies have undergone rapid evolution in healthcare and medicine, from apps to computer software able to analyze medical images, robotic surgery and advanced data storage system. The main aim of the present commentary is to briefly describe the evolution of AI and its applications in healthcare, particularly in nutrition and clinical biochemistry. Indeed, AI is revealing itself to be an important tool in clinical nutrition by using telematic means to self-monitor various health metrics, including blood glucose levels, body weight, heart rate, fat percentage, blood pressure, activity tracking and calorie intake trackers. In particular, the application of the most common digital technologies used in the field of nutrition as well as the employment of AI in the management of diabetes and obesity, two of the most common nutrition-related pathologies worldwide, will be presented. metadata Salinari, Alessia and Machì, Michele and Armas Diaz, Yasmany and Cianciosi, Danila and Qi, Zexiu and Yang, Bei and Ferreiro Cotorruelo, Maria Soledad and Gracia Villar, Santos and Dzul López, Luis Alonso and Battino, Maurizio and Giampieri, Francesca mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, santos.gracia@uneatlantico.es, luis.dzul@uneatlantico.es, maurizio.battino@uneatlantico.es, francesca.giampieri@uneatlantico.es (2023) The Application of Digital Technologies and Artificial Intelligence in Healthcare: An Overview on Nutrition Assessment. Diseases, 11 (3). p. 97. ISSN 2079-9721

Article Subjects > Biomedicine
Subjects > Engineering Europe University of Atlantic > Research > Scientific Production
Fundación Universitaria Internacional de Colombia > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production Abierto Inglés Artificial intelligence has made substantial progress in medicine. Automated dental imaging interpretation is one of the most prolific areas of research using AI. X-ray and infrared imaging systems have enabled dental clinicians to identify dental diseases since the 1950s. However, the manual process of dental disease assessment is tedious and error-prone when diagnosed by inexperienced dentists. Thus, researchers have employed different advanced computer vision techniques, and machine- and deep-learning models for dental disease diagnoses using X-ray and near-infrared imagery. Despite the notable development of AI in dentistry, certain factors affect the performance of the proposed approaches, including limited data availability, imbalanced classes, and lack of transparency and interpretability. Hence, it is of utmost importance for the research community to formulate suitable approaches, considering the existing challenges and leveraging findings from the existing studies. Based on an extensive literature review, this survey provides a brief overview of X-ray and near-infrared imaging systems. Additionally, a comprehensive insight into challenges faced by researchers in the dental domain has been brought forth in this survey. The article further offers an amalgamative assessment of both performances and methods evaluated on public benchmarks and concludes with ethical considerations and future research avenues. metadata Shafi, Imran and Fatima, Anum and Afzal, Hammad and Díez, Isabel de la Torre and Lipari, Vivian and Breñosa, Jose and Ashraf, Imran mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, vivian.lipari@uneatlantico.es, josemanuel.brenosa@uneatlantico.es, UNSPECIFIED (2023) A Comprehensive Review of Recent Advances in Artificial Intelligence for Dentistry E-Health. Diagnostics, 13 (13). p. 2196. ISSN 2075-4418

Article Subjects > Biomedicine
Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Inglés The genus Aeromonas has received constant attention in different areas, from aquaculture and veterinary medicine to food safety, where more and more frequent isolates are occurring with increased resistance to antibiotics. The present paper studied the interaction of Aeromonas strains isolated from fresh produce and water with different eukaryotic cell types with the aim of better understanding the cytotoxic capacity of these strains. To study host-cell pathogen interactions in Aeromonas, we used HT-29, Vero, J774A.1, and primary mouse embryonic fibroblasts. These interactions were analyzed by confocal microscopy to determine the cytotoxicity of the strains. We also used Galleria mellonella larvae to test their pathogenicity in this experimental model. Our results demonstrated that two strains showed high cytotoxicity in epithelial cells, fibroblasts, and macrophages. Furthermore, these strains showed high virulence using the G. mellonella model. All strains used in this paper generally showed low levels of resistance to the different families of the antibiotics being tested. These results indicated that some strains of Aeromonas present in vegetables and water pose a potential health hazard, displaying very high in vitro and in vivo virulence. This pathogenic potential, and some recent concerning findings on antimicrobial resistance in Aeromonas, encourage further efforts in examining the precise significance of Aeromonas strains isolated from foods for human consumption. metadata Pintor-Cora, Alberto and Tapia Martínez, Olga and Elexpuru Zabaleta, Maria and Ruiz de Alegría, Carlos and Rodríguez-Calleja, Jose M. and Santos, Jesús A. and Ramos Vivas, Jose mail UNSPECIFIED, olga.tapia@uneatlantico.es, maria.elexpuru@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, jose.ramos@uneatlantico.es (2023) Cytotoxicity and Antimicrobial Resistance of Aeromonas Strains Isolated from Fresh Produce and Irrigation Water. Antibiotics, 12 (3). p. 511. ISSN 2079-6382

Article Subjects > Biomedicine
Subjects > Engineering Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production Abierto Inglés A novel approach is presented in this study for the classification of lower limb disorders, with a specific emphasis on the knee, hip, and ankle. The research employs gait analysis and the extraction of PoseNet features from video data in order to effectively identify and categorize these disorders. The PoseNet algorithm facilitates the extraction of key body joint movements and positions from videos in a non-invasive and user-friendly manner, thereby offering a comprehensive representation of lower limb movements. The features that are extracted are subsequently standardized and employed as inputs for a range of machine learning algorithms, such as Random Forest, Extra Tree Classifier, Multilayer Perceptron, Artificial Neural Networks, and Convolutional Neural Networks. The models undergo training and testing processes using a dataset consisting of 174 real patients and normal individuals collected at the Tehsil Headquarter Hospital Sadiq Abad. The evaluation of their performance is conducted through the utilization of K-fold cross-validation. The findings exhibit a notable level of accuracy and precision in the classification of various lower limb disorders. Notably, the Artificial Neural Networks model achieves the highest accuracy rate of 98.84%. The proposed methodology exhibits potential in enhancing the diagnosis and treatment planning of lower limb disorders. It presents a non-invasive and efficient method of analyzing gait patterns and identifying particular conditions. metadata Siddiqui, Hafeez Ur Rehman and Saleem, Adil Ali and Raza, Muhammad Amjad and Gracia Villar, Santos and Dzul Lopez, Luis and Diez, Isabel de la Torre and Rustam, Furqan and Dudley, Sandra mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, santos.gracia@uneatlantico.es, luis.dzul@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2023) Empowering Lower Limb Disorder Identification through PoseNet and Artificial Intelligence. Diagnostics, 13 (18). p. 2881. ISSN 2075-4418

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Inglés Antimicrobial and multidrug resistance (MDR) pathogens are becoming one of the major health threats among children. Integrated studies on the molecular epidemiology and prevalence of AMR and MDR diarrheal pathogens are lacking. A total of 404 fecal specimens were collected from children with diarrhea in Bangladesh from January 2019 to December 2021. We used conventional bacteriologic and molecular sequence analysis methods. Phenotypic and genotypic resistance were determined by disk diffusion and molecular sequencing methods. Fisher’s exact tests with 95% confidence intervals (CIs) was performed. Prevalence of bacterial infection was 63% (251 of 404) among children with diarrhea. E. coli (29%) was the most prevalent. E. coli, Shigella spp., V. cholerae, and Salmonella spp., showed the highest frequency of resistance against ceftriaxone (75–85%), and erythromycin (70–75%%). About 10–20% isolates of E. coli, V. cholerae and Shigella spp. showed MDR against cephem, macrolides, and quinolones. Significant association (p value < 0.05) was found between the phenotypic and genotypic resistance. The risk of diarrhea was the highest among the patients co-infected with E. coli and rotavirus [OR 3.6 (95% CI 1.1–5.4) (p = 0.001)] followed by Shigella spp. and rotavirus [OR 3.5 (95% CI 0.5–5.3) (p = 0.001)]. This study will provide an integrated insight of molecular epidemiology and antimicrobial resistance profiling of bacterial pathogens among children with diarrhea in Bangladesh. metadata Sharif, Nadim and Ahmed, Shamsun Nahar and Khandaker, Shamim and Monifa, Nuzhat Haque and Abusharha, Ali and Ramírez-Vargas, Debora L. and Díez, Isabel De la Torre and Kuc Castilla, Ángel Gabriel and Talukder, Ali Azam and Parvez, Anowar Khasru and Dey, Shuvra Kanti mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, debora.ramirez@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2023) Multidrug resistance pattern and molecular epidemiology of pathogens among children with diarrhea in Bangladesh, 2019–2021. Scientific Reports, 13 (1). ISSN 2045-2322

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Fundación Universitaria Internacional de Colombia > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production Abierto Inglés Background: Nowadays, there is no gold standard score for prehospital sepsis and sepsis-related mortality identification. The aim of the present study was to analyze the performance of qSOFA, NEWS2 and mSOFA as sepsis predictors in patients with infection-suspected in prehospital care. The second objective is to study the predictive ability of the aforementioned scores in septic-shock and in-hospital mortality. Methods: Prospective, ambulance-based, and multicenter cohort study, developed by the emergency medical services, among patients (n = 535) with suspected infection transferred by ambulance with high-priority to the emergency department (ED). The study enrolled 40 ambulances and 4 ED in Spain between 1 January 2020, and 30 September 2021. All the variables used in the scores, in addition to socio-demographic data, standard vital signs, prehospital analytical parameters (glucose, lactate, and creatinine) were collected. For the evaluation of the scores, the discriminative power, calibration curve and decision curve analysis (DCA) were used. Results: The mSOFA outperformed the other two scores for mortality, presenting the following AUCs: 0.877 (95%CI 0.841–0.913), 0.761 (95%CI 0.706–0.816), 0.731 (95%CI 0.674–0.788), for mSOFA, NEWS, and qSOFA, respectively. No differences were found for sepsis nor septic shock, but mSOFA’s AUCs was higher than the one of the other two scores. The calibration curve and DCA presented similar results. Conclusion: The use of mSOFA could provide and extra insight regarding the short-term mortality and sepsis diagnostic, backing its recommendation in the prehospital scenario. metadata Melero-Guijarro, Laura and Sanz-García, Ancor and Martín-Rodríguez, Francisco and Lipari, Vivian and Mazas Pérez-Oleaga, Cristina and Carvajal-Altamiranda, Stefanía and Martínez López, Nohora Milena and Dominguez Azpíroz, Irma and Castro Villamor, Miguel A. and Sánchez Soberón, Irene and López-Izquierdo, Raúl mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, vivian.lipari@uneatlantico.es, cristina.mazas@uneatlantico.es, stefania.carvajal@uneatlantico.es, nohora.martinez@uneatlantico.es, irma.dominguez@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2023) Prehospital qSOFA, mSOFA, and NEWS2 performance for sepsis prediction: A prospective, multi-center, cohort study. Frontiers in Medicine, 10. ISSN 2296-858X

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Fundación Universitaria Internacional de Colombia > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production Abierto Inglés Mutations allow viruses to continuously evolve by changing their genetic code to adapt to the hosts they infect. It is an adaptive and evolutionary mechanism that helps viruses acquire characteristics favoring their survival and propagation. The COVID-19 pandemic declared by the WHO in March 2020 is caused by the SARS-CoV-2 virus. The non-stop adaptive mutations of this virus and the emergence of several variants over time with characteristics favoring their spread constitute one of the biggest obstacles that researchers face in controlling this pandemic. Understanding the mutation mechanism allows for the adoption of anticipatory measures and the proposal of strategies to control its propagation. In this study, we focus on the mutations of this virus, and we propose the SARSMutOnto ontology to model SARS-CoV-2 mutations reported by Pango researchers. A detailed description is given for each mutation. The genes where the mutations occur and the genomic structure of this virus are also included. The sub-lineages and the recombinant sub-lineages resulting from these mutations are additionally represented while maintaining their hierarchy. We developed a Python-based tool to automatically generate this ontology from various published Pango source files. At the end of this paper, we provide some examples of SPARQL queries that can be used to exploit this ontology. SARSMutOnto might become a ‘wet bench’ machine learning tool for predicting likely future mutations based on previous mutations. metadata Bakkas, Jamal and Hanine, Mohamed and Chekry, Abderrahman and Gounane, Said and de la Torre Díez, Isabel and Lipari, Vivian and Martínez López, Nohora Milena and Ashraf, Imran mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, vivian.lipari@uneatlantico.es, nohora.martinez@uneatlantico.es, UNSPECIFIED (2023) SARSMutOnto: An Ontology for SARS-CoV-2 Lineages and Mutations. Viruses, 15 (2). p. 505. ISSN 1999-4915

Article Subjects > Biomedicine
Subjects > Engineering
Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production Cerrado Inglés Obesity and overweight has increased in the last year and has become a pandemic disease, the result of sedentary lifestyles and unhealthy diets rich in sugars, refined starches, fats and calories. Machine learning (ML) has proven to be very useful in the scientific community, especially in the health sector. With the aim of providing useful tools to help nutritionists and dieticians, research focused on the development of ML and Deep Learning (DL) algorithms and models is searched in the literature. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol has been used, a very common technique applied to carry out revisions. In our proposal, 17 articles have been filtered in which ML and DL are applied in the prediction of diseases, in the delineation of treatment strategies, in the improvement of personalized nutrition and more. Despite expecting better results with the use of DL, according to the selected investigations, the traditional methods are still the most used and the yields in both cases fluctuate around positive values, conditioned by the databases (transformed in each case) to a greater extent than by the artificial intelligence paradigm used. Conclusions: An important compilation is provided for the literature in this area. ML models are time-consuming to clean data, but (like DL) they allow automatic modeling of large volumes of data which makes them superior to traditional statistics. metadata Ferreras, Antonio and Sumalla Cano, Sandra and Martínez-Licort, Rosmeri and Elío Pascual, Iñaki and Tutusaus, Kilian and Prola, Thomas and Vidal Mazón, Juan Luis and Sahelices, Benjamín and de la Torre Díez, Isabel mail UNSPECIFIED, sandra.sumalla@uneatlantico.es, UNSPECIFIED, inaki.elio@uneatlantico.es, kilian.tutusaus@uneatlantico.es, thomas.prola@uneatlantico.es, juanluis.vidal@uneatlantico.es, UNSPECIFIED, UNSPECIFIED (2023) Systematic Review of Machine Learning applied to the Prediction of Obesity and Overweight. Journal of Medical Systems, 47 (1). ISSN 1573-689X

Article Subjects > Biomedicine
Subjects > Engineering Europe University of Atlantic > Research > Scientific Production
Fundación Universitaria Internacional de Colombia > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production Abierto Inglés This study sought to investigate how different brain regions are affected by Alzheimer’s disease (AD) at various phases of the disease, using independent component analysis (ICA). The study examines six regions in the mild cognitive impairment (MCI) stage, four in the early stage of Alzheimer’s disease (AD), six in the moderate stage, and six in the severe stage. The precuneus, cuneus, middle frontal gyri, calcarine cortex, superior medial frontal gyri, and superior frontal gyri were the areas impacted at all phases. A general linear model (GLM) is used to extract the voxels of the previously mentioned regions. The resting fMRI data for 18 AD patients who had advanced from MCI to stage 3 of the disease were obtained from the ADNI public source database. The subjects include eight women and ten men. The voxel dataset is used to train and test ten machine learning algorithms to categorize the MCI, mild, moderate, and severe stages of Alzheimer’s disease. The accuracy, recall, precision, and F1 score were used as conventional scoring measures to evaluate the classification outcomes. AdaBoost fared better than the other algorithms and obtained a phenomenal accuracy of 98.61%, precision of 99.00%, and recall and F1 scores of 98.00% each. metadata Shahzadi, Samra and Butt, Naveed Anwer and Sana, Muhammad Usman and Elío Pascual, Iñaki and Briones Urbano, Mercedes and Díez, Isabel de la Torre and Ashraf, Imran mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, inaki.elio@uneatlantico.es, mercedes.briones@uneatlantico.es, UNSPECIFIED, UNSPECIFIED (2023) Voxel Extraction and Multiclass Classification of Identified Brain Regions across Various Stages of Alzheimer’s Disease Using Machine Learning Approaches. Diagnostics, 13 (18). p. 2871. ISSN 2075-4418

2022

Article Subjects > Biomedicine
Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Inglés Background: The aim of this study was to relate adherence to the Mediterranean diet (MedDiet) to the prevalence of metabolic syndrome (MetS) in an elderly population from the north of Spain. Methods: We carried out an observational, descriptive, cross-sectional, and correlational study involving 556 non-institutionalised individuals aged 65 to 79 years. The MEDAS-14 questionnaire score was used to define the degree of adherence to the Mediterranean diet. The diagnosis of MetS was conducted using the International Diabetes Federation (IDF) criteria. Results: In 264 subjects with an average age of 71.9 (SD: ±4.2), 39% of whom were men, 36.4% had good adherence (score ≥ 9 in MEDAS-14), with no differences by gender or age. The prevalence of MetS was 40.2%, with 47.6% in men and 35.4% in women (p < 0.05). The prevalence of MetS was 2.4 times more frequent among individuals who consumed less than two servings (200 g) of vegetables daily compared with those who consumed two or more servings of vegetables daily (OR: 2.368, 95%CI: 1.141–4.916, p = 0.021). Low adherence to the MedDiet (MEDAS-14 score ≤ 8) was associated with an 82% higher prevalence of MetS (OR: 1.817, 95%CI: 1.072–3.081, p = 0.027). Conclusion: An inverse relationship was established between adherence to the MedDiet and the prevalence of MetS metadata Cubas-Basterrechea, Gloria and Elío Pascual, Iñaki and Alonso, Guzmán and Otero, Luis and Gutiérrez-Bardeci, Luis and Puente, Jesús and Muñoz-Cacho, Pedro mail UNSPECIFIED, inaki.elio@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2022) Adherence to the Mediterranean Diet Is Inversely Associated with the Prevalence of Metabolic Syndrome in Older People from the North of Spain. Nutrients, 14 (21). p. 4536. ISSN 2072-6643

Article Subjects > Biomedicine
Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Inglés Alzheimer's is a chronic degenerative disease of the central nervous system considered the leading cause of dementia in the world. It is characterized by two etiopathological events related to oxidative stress: the aggregation of β-amyloid peptide and the formation of neurofibrillary tangles of hyperphosphorylated Tau protein in the brain. The incidence of this disease increases with age and has been associated with inadequate lifestyles. Some natural compounds have been shown to improve the hallmarks of the disease. However, despite its potential, there is no scientific evidence about Manuka honey (MH) in this regard. In the present work we evaluated the effect of MH on the toxicity induced by Aβ aggregation and Tau in a Caenorhabditis elegans model. Our results demonstrated that MH was able to improve indicators of oxidative stress and delayed Aβ-induced paralysis in the AD model CL4176 through HSP-16.2 and SKN-1/NRF2 pathways. Nevertheless, its sugar content impaired the indicators of locomotion (an indicator of tau neurotoxicity) in both the transgenic strain BR5706 and in the wild-type N2 worms. metadata Navarro-Hortal, María D. and Romero-Márquez, Jose M. and Muñoz-Ollero, Pedro and Jiménez-Trigo, Victoria and Esteban-Muñoz, Adelaida and Tutusaus, Kilian and Giampieri, Francesca and Battino, Maurizio and Sánchez-González, Cristina and Rivas-García, Lorenzo and Llopis, Juan and Forbes-Hernández, Tamara Y. and Quiles, José L. mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, kilian.tutusaus@uneatlantico.es, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, jose.quiles@uneatlantico.es (2022) Amyloid β-but not Tau-induced neurotoxicity is suppressed by Manuka honey via HSP-16.2 and SKN-1/Nrf2 pathways in an in vivo model of Alzheimer's disease. Food & Function. ISSN 2042-6496

Article Subjects > Biomedicine Ibero-american International University > Research > Scientific Production Abierto Inglés Objective: Women with gynecologic cancer may sufer from pelvic foor dysfunction (PFD). Before radiotherapy, prehabilitation with pelvic foor muscle exercises (PFME) and vaginal dilator (VD) might prevent it and foster sexual life. This study aims to explore the experience of gynecologic cancer patients getting external beam radiation treatments regarding barriers to and facilitators of adherence to a prehabilitation program to prevent PFD. Methods: This qualitative research with thematic content analysis included 11 women with gynecologic cancer and diferent levels of adherence to PFME and VD. Participants were interviewed based on a semi-structured script. The information was analyzed manually, assisted with Nvivo12® software, and triangulated with open coding. Results: High self-motivation, desire to improve their health, symptoms of improvement, availability of time, the desire to resume sexual life, and the support of the partner were facilitators of adherence. The instructional exercise audio, clarity of the information, and closer communication with the physical therapist were also valued. The main barriers were general malaise secondary to oncological treatments, forgetfulness, lack of time, misinformation, lack of coordination with the treatment team, discomfort with the VD, and a feeling of shame. Feedback from the attending physician was a facilitator when present or a barrier when absent. Conclusion: These barriers and facilitators should be considered when designing and implementing preventive programs with PFME and VD. Behavioral counselling should consider the desire to remain sexually active; in such cases, including the partner in the therapeutic process is appraised. Otherwise, the focus should be on benefts for maintenance of pelvic foor function. metadata Araya, Paulina and Roa-Alcaino, Sonia and Celedón, Claudia and Cuevas-Said, Mónica and de Sousa Dantas, Diego and Sacomori, Cinara mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, csacomori@yahoo.com.br (2022) Barriers to and facilitators of adherence to pelvic floor muscle exercises and vaginal dilator use among gynecologic cancer patients: a qualitative study. Supportive Care in Cancer. ISSN 0941-4355

Article Subjects > Biomedicine
Subjects > Nutrition Ibero-american International University > Research > Scientific Production Abierto Español Introducción: el objetivo del presente trabajo se centra en reconocer la importancia de las investigaciones que relacionan la biodisponibilidad de fósforo en diferentes grupos de alimentos de origen animal, vegetal e industrial y su efecto en la progresión de la enfermedad renal crónica (ERC). Metodología: la revisión se sustentó en la búsqueda literaria en páginas web como PUBMED, Redalyc, SciELO, SCIHUB y Google Academic. Se seleccionó cada estudio, descartando aquellos que no fueran cuantitativos u originales, estuvieran incompletos, sin metodología clara, realizados en mamíferos o si los resultados no se especificaban en porcentajes. La lectura puso especial énfasis en el índice de biodisponibilidad de fósforo derivado del consumo de distintos productos alimenticios. Se elaboraron tres matrices de acuerdo con el origen del comestible y la biodisponibilidad de fósforo que absorbe el organismo. Resultados: se encontró que los alimentos industrializados y los aditivos muestran una biodisponibilidad de fósforo del 90 % al 100 %, los de origen animal del 40 % al 80 % y los de origen vegetal del 30 %. Conclusiones: los aditivos de los alimentos industrializados promueven la hiperfosfatemia y, con ello, aceleran la progresión de la enfermedad renal crónica, a diferencia de los de origen animal y vegetal, menos perjudiciales para la salud. Esto da pauta a la formación del sector salud para ampliar su conocimiento sobre el tratamiento nutricional del paciente. metadata Martínez Hernández, Eduardo and De La Luz Maya, Rodolfo A. and Ramírez Robledo, María De Los Á and Núñez-Murillo, Gabriela K. and Orozco González, Nelly mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, nelly.orozco@unini.edu.mx (2022) Biodisponibilidad de fósforo en alimentos y su efecto en la enfermedad renal crónica. Población y Salud en Mesoamérica, 19 (2). pp. 293-320.

Article Subjects > Biomedicine Ibero-american International University > Research > Scientific Production Abierto Español The COVID-19 pandemic has put a lot of pressure on health systems worldwide. Mass vaccination against SARS-CoV-2 has reduced morbidity and mortality worldwide. Despite their safety profiles, vaccines, as with any other medical product, can cause adverse events. Yet, in countries with poor epidemiological surveillance and monitoring systems, reporting vaccine-related adverse events is a challenge. The objective of this study was to describe self-reported vaccine adverse events after receiving one of the available COVID-19 vaccine schemes in Ecuador. A cross-sectional analysis based on an online, self-reported, 32-item questionnaire was conducted in Ecuador from 1 April to 15 July 2021. Participants were invited by social media, radio, and TV to voluntarily participate in our study. A total of 6654 participants were included in this study. Furthermore, 38.2% of the participants reported having at least one comorbidity. Patients received AstraZeneca, Pfizer, and Sinovac vaccines, and these were distributed 38.4%, 31.1%, and 30.5%, respectively. Overall, pain or swelling at the injection site 17.2% (n = 4500) and headache 13.3% (n = 3502) were the most reported adverse events. Women addressed events supposedly attributable to vaccination or immunization [ESAVIs] (66.7%), more often than men (33.2%). After receiving the first dose of any available COVID-19 vaccine, a total of 19,501 self-reported ESAVIs were informed (87.0% were mild, 11.5% moderate, and 1.5% severe). In terms of the vaccine type and brand, the most reactogenic vaccine was AstraZeneca with 57.8%, followed by Pfizer (24.9%) and Sinovac (17.3%). After the second dose, 6776 self-reported ESAVIs were reported (87.1% mild, 10.9% moderate, and 2.1% severe). AstraZeneca vaccine users reported a higher proportion of ESAVIs (72.2%) in comparison to Pfizer/BioNTech (15.9%) and Sinovac Vaccine (11.9%). Swelling at the injection site, headache, muscle pain, and fatigue were the most common ESAVIs for the first as well as second doses. In conclusion, most ESAVIs were mild. AstraZeneca users were more likely to report adverse events. Participants without a history of COVID-19 infection, as well as those who received the first dose, were more prone to report ESAVIs metadata Ortiz-Prado, Esteban and Izquierdo Condoy, Juan Sebastian and Fernandez-Naranjo, Raul and Simbaña-Rivera, Katherine and Vásconez-González, Jorge and Naranjo, Eddy P. Lincango and Cordovez, Simone and Coronel, Barbara and Delgado-Moreira, Karen and Jimbo-Sotomayor, Ruth mail UNSPECIFIED (2022) A Comparative Analysis of a Self-Reported Adverse Events Analysis after Receiving One of the Available SARS-CoV-2 Vaccine Schemes in Ecuador. Vaccines, 10 (7). p. 1047. ISSN 2076-393X

Article Subjects > Biomedicine
Subjects > Engineering Ibero-american International University > Research > Scientific Production Cerrado Inglés According to the World Health Organization (WHO), Parkinson’s disease (PD) is a neurodegenerative disease of the brain that causes motor symptoms including slower movement, rigidity, tremor, and imbalance in addition to other problems like Alzheimer’s disease (AD), psychiatric problems, insomnia, anxiety, and sensory abnormalities. Techniques including artificial intelligence (AI), machine learning (ML), and deep learning (DL) have been established for the classification of PD and normal controls (NC) with similar therapeutic appearances in order to address these problems and improve the diagnostic procedure for PD. In this article, we examine a literature survey of research articles published up to September 2022 in order to present an in-depth analysis of the use of datasets, various modalities, experimental setups, and architectures that have been applied in the diagnosis of subjective disease. This analysis includes a total of 217 research publications with a list of the various datasets, methodologies, and features. These findings suggest that ML/DL methods and novel biomarkers hold promising results for application in medical decision-making, leading to a more methodical and thorough detection of PD. Finally, we highlight the challenges and provide appropriate recommendations on selecting approaches that might be used for subgrouping and connection analysis with structural magnetic resonance imaging (sMRI), DaTSCAN, and single-photon emission computerized tomography (SPECT) data for future Parkinson’s research. metadata Rana, Arti and Dumka, Ankur and Singh, Rajesh and Panda, Manoj Kumar and Priyadarshi, Neeraj mail UNSPECIFIED (2022) A Computerized Analysis with Machine Learning Techniques for the Diagnosis of Parkinson’s Disease: Past Studies and Future Perspectives. Diagnostics, 12 (11). p. 2708. ISSN 2075-4418

Article Subjects > Biomedicine
Subjects > Engineering Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production Abierto Inglés Asthma is a deadly disease that affects the lungs and air supply of the human body. Coronavirus and its variants also affect the airways of the lungs. Asthma patients approach hospitals mostly in a critical condition and require emergency treatment, which creates a burden on health institutions during pandemics. The similar symptoms of asthma and coronavirus create confusion for health workers during patient handling and treatment of disease. The unavailability of patient history to physicians causes complications in proper diagnostics and treatments. Many asthma patient deaths have been reported especially during pandemics, which necessitates an efficient framework for asthma patients. In this article, we have proposed a blockchain consortium healthcare framework for asthma patients. The proposed framework helps in managing asthma healthcare units, coronavirus patient records and vaccination centers, insurance companies, and government agencies, which are connected through the secure blockchain network. The proposed framework increases data security and scalability as it stores encrypted patient data on the Interplanetary File System (IPFS) and keeps data hash values on the blockchain. The patient data are traceable and accessible to physicians and stakeholders, which helps in accurate diagnostics, timely treatment, and the management of patients. The smart contract ensures the execution of all business rules. The patient profile generation mechanism is also discussed. The experiment results revealed that the proposed framework has better transaction throughput, query delay, and security than existing solutions metadata Farooq, Muhammad Shoaib and Suhail, Maryam and Qureshi, Junaid Nasir and Rustam, Furqan and de la Torre Díez, Isabel and Vidal Mazón, Juan Luis and Rodríguez Velasco, Carmen Lilí and Ashraf, Imran mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, juanluis.vidal@uneatlantico.es, carmen.rodriguez@uneatlantico.es, UNSPECIFIED (2022) Consortium Framework Using Blockchain for Asthma Healthcare in Pandemics. Sensors, 22 (21). p. 8582. ISSN 1424-8220

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Inglés The authors have requested to update the original publication of this article. Duplicate text in the second and third paragraphs of page 5 should be deleted. Acknowledgments section should be removed. The original article has been corrected. metadata Montano, Isabel Herrera and Lafuente, Elena Presencio and Breñosa, Jose and Ortega-Mansilla, Arturo and Díez, Isabel de la Torre and Río-Solá, María Lourdes Del mail UNSPECIFIED, UNSPECIFIED, josemanuel.brenosa@uneatlantico.es, arturo.ortega@uneatlantico.es, UNSPECIFIED, UNSPECIFIED (2022) Correction to: Systematic Review of Telemedicine and eHealth Systems Applied to Vascular Surgery. Journal of Medical Systems, 47 (1). ISSN 1573-689X

Article Subjects > Biomedicine
Subjects > Nutrition Ibero-american International University > Research > Scientific Production Abierto Inglés The authors regret the incorrect publication of the actual affiliation for the author José Ramos-Vivas in the original article. The corrected affiliation is provided below: Luis Monzón-Atienzaa, Jimena Bravoa, Álvaro Fernández-Monteroa, Ives Charlie-Silvab, Daniel Monteroa, José Ramos-Vivasa,d,e, Jorge Galindo-Villegasc,*, Félix Acostaa aGrupo de Investigaci'on en Acuicultura (GIA), Instituto Ecoaqua, Universidad de Las Palmas de Gran Canaria, Spain bDepartment of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil cFaculty of Biosciences and Aquaculture, Nord University, Bodø, Norway dResearch Group on Foods, Nutritional Biochemistry and Health, Universidad Europea del Atlántico, 39011 Santander, Spain eDepartment of Project Management, Universidad Internacional Iberoamericana, Campeche 24560, Mexico The authors would like to apologise for any inconvenience caused. metadata Monzón-Atienza, Luis and Bravo, Jimena and Fernández-Montero, Álvaro and Charlie-Silva, Ives and Montero, Daniel and Ramos Vivas, Jose and Galindo-Villegas, Jorge and Acosta, Félix mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, jose.ramos@uneatlantico.es, UNSPECIFIED, UNSPECIFIED (2022) Corrigendum to “Dietary supplementation of Bacillus velezensis improves Vibrio anguillarum clearance in European sea bass by activating essential innate immune mechanisms” [Fish Shellfish Immunol. 124 (2022) 244–253]. Fish & Shellfish Immunology. ISSN 10504648

Article Subjects > Biomedicine
Subjects > Engineering Europe University of Atlantic > Research > Scientific Production
Fundación Universitaria Internacional de Colombia > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production Abierto Español Patient care and convenience remain the concern of medical professionals and caregivers alike. An unconscious patient confined to a bed may develop fluid accumulation and pressure sores due to inactivity and deficiency of oxygen flow. Moreover, weight monitoring is crucial for an effective treatment plan, which is difficult to measure for bedridden patients. This paper presents the design and development of a smart and cost-effective independent system for lateral rotation, movement, weight measurement, and transporting immobile patients. Optimal dimensions and practical design specifications are determined by a survey across various hospitals. Subsequently, the proposed hoist-based weighing and turning mechanism is CAD-modeled and simulated. Later, the structural analysis is carried out to select suitable metallurgy for various sub-assemblies to ensure design reliability. After fabrication, optimization, integration, and testing procedures, the base frame is designed to mount a hydraulic motor for the actuator, a DC power source for self-sustenance, and lockable wheels for portability. The installation of a weighing scale and a hydraulic actuator is ensured to lift the patient for weight measuring up to 600 pounds or lateral turning of 80 degrees both ways. The developed system offers simple operating characteristics, allows for keeping patient weight records, and assists nurses in changing patients’ lateral positions both ways, comfortably massage patients’ backs, and transport them from one bed to another. Additionally, being lightweight offers reduced contact with the patient to increase the healthcare staff’s safety in pandemics; it is also height adjustable and portable, allowing for use with multiple-sized beds and easy transportation across the medical facility. The feedback from paramedics is encouraging regarding reducing labor-intensive nursing tasks, alleviating the discomfort of long-term bed-ridden patients, and allowing medical practitioners to suggest better treatment plans metadata Shafi, Imran and Farooq, Muhammad Siddique and De La Torre Díez, Isabel and Breñosa, Jose and Martínez Espinosa, Julio César and Ashraf, Imran mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, josemanuel.brenosa@uneatlantico.es, ulio.martinez@unini.edu.mx, UNSPECIFIED (2022) Design and Development of Smart Weight Measurement, Lateral Turning and Transfer Bedding for Unconscious Patients in Pandemics. Healthcare, 10 (11). p. 2174. ISSN 2227-9032

Article Subjects > Biomedicine
Subjects > Engineering Europe University of Atlantic > Research > Scientific Production
Fundación Universitaria Internacional de Colombia > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production Abierto Inglés The diagnosis of early-stage lung cancer is challenging due to its asymptomatic nature, especially given the repeated radiation exposure and high cost of computed tomography(CT). Examining the lung CT images to detect pulmonary nodules, especially the cell lung cancer lesions, is also tedious and prone to errors even by a specialist. This study proposes a cancer diagnostic model based on a deep learning-enabled support vector machine (SVM). The proposed computer-aided design (CAD) model identifies the physiological and pathological changes in the soft tissues of the cross-section in lung cancer lesions. The model is first trained to recognize lung cancer by measuring and comparing the selected profile values in CT images obtained from patients and control patients at their diagnosis. Then, the model is tested and validated using the CT scans of both patients and control patients that are not shown in the training phase. The study investigates 888 annotated CT scans from the publicly available LIDC/IDRI database. The proposed deep learning-assisted SVM-based model yields 94% accuracy for pulmonary nodule detection representing early-stage lung cancer. It is found superior to other existing methods including complex deep learning, simple machine learning, and the hybrid techniques used on lung CT images for nodule detection. Experimental results demonstrate that the proposed approach can greatly assist radiologists in detecting early lung cancer and facilitating the timely management of patients. metadata Shafi, Imran and Din, Sadia and Khan, Asim and Díez, Isabel De La Torre and Pali-Casanova, Ramón and Tutusaus, Kilian and Ashraf, Imran mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, ramon.pali@unini.edu.mx, kilian.tutusaus@uneatlantico.es, UNSPECIFIED (2022) An Effective Method for Lung Cancer Diagnosis from CT Scan Using Deep Learning-Based Support Vector Network. Cancers, 14 (21). p. 5457. ISSN 2072-6694

Thesis Subjects > Biomedicine
Subjects > Social Sciences Ibero-american International University > Research > Doctoral Thesis Cerrado Español Introducción: Es de gran importancia considerar las percepciones del usuario a través de trabajos que mesuren la satisfacción para poder realizar una evaluación de los resultados del proceso de asistencia en salud con el fin de adecuar de manera acorde los servicios que son brindados, siendo que esta evaluación para las organizaciones debe ser considerada una prioridad. Si se ofrecen servicios de salud con altos estándares de calidad autopercibidos por parte de los usuarios, permitirá que se pueda generar una fidelización y una longitudinalidad en la asistencia sanitaria, lo cual también puede aportar a disminuir los costos asociados a la elevada carga de enfermedades crónicas no transmisibles y a la elevada medicalización de la población. Metodología: Se ha realizado un trabajo con un diseño correlacional, transversal y no experimental. Se ha encuestado a 407 personas que acudieron a 7 centros de Atención Primaria de la Salud de la ciudad de Rosario, Argentina. El instrumento de evaluación fue un cuestionario autoadministrado tipo SERVPERF con una escala Likert de 5 puntos. El cuestionario determinó el perfil demográfico, la presencia de enfermedades crónicas no transmisibles y la conducta de medicalización de la muestra seleccionada. Además, se midió la calidad asistencial tomando en cuenta cuatro dimensiones que componen este constructo: Calidad del uso de programas de salud, Satisfacción del paciente, Confianza del paciente e Intención de revisita del paciente. Se evaluaron los datos obtenidos usando estadística de segunda generación mediante la evaluación multivariada mediante modelamiento de ecuaciones estructurales por mínimos cuadrados parciales (SEM-PLS) para calcular los valores de correlación entre las variables de estudio. Resultados: Se puede afirmar que las rutas directas entre: calidad de los servicios de salud y satisfacción, calidad de los servicios de salud y confianza, calidad de los servicios de salud y satisfacción, entre calidad de los servicios de salud y satisfacción y entre calidad de los servicios de salud y la satisfacción, han sido estadísticamente significativas (p < 0,005). Mientras que la ruta directa entre la calidad de los servicios de salud y la satisfacción no es estadísticamente significativa (p = 0,821). Conclusión: se puede observar que todas las trayectorias son significativas, exceptuando la trayectoria Calidad e Intención de revisita, lo cual permite afirmar que, para que los usuarios del servicio de salud tengan la intención de volver a asistir al mismo efector, deben percibir una calidad asistencial alta, pero que esta última se debe principalmente a la influencia que tenga ésta sobre otras rutas indirectas. Estas rutas indirectas se han comprobado mediante un estudio de la significación de los coeficientes, demostrando así que la satisfacción y la confianza son dimensiones que impactan más significativamente para que el paciente perciba una calidad asistencial alta, con el fin de que tenga finalmente intención de revisita. metadata Pighin, Massimo mail massimopighin94@gmail.com (2022) Factores de la intención de revisita de los pacientes del sistema de atención primaria de la salud de la ciudad de Rosario, Argentina mediante modelamiento con ecuaciones estructurales por el método de mínimos cuadrados parciales (SEM PLS). Doctoral thesis, UNSPECIFIED.

Article Subjects > Biomedicine
Subjects > Physical Education and Sport
Subjects > Nutrition Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Español El presente estudio tiene como objetivo determinar las relaciones entre los valores de funcionalidad motriz, estado nutricional e índices antropométricos de salud en adolescentes chilenos de 12 a 15 años. Estudio de corte transversal con una muestra no probabilística y por conveniencia, con una muestra final de 384 escolares (13,04 ± 0,85 años). Todos los participantes asistieron a dos sesiones de evaluación, donde se les realizó un registro de la historia clínica y una examinación física médica. En la segunda sesión, se realizaron evaluaciones antropométricas y las pruebas consideradas en la batería Functional Movement Screen (FMS). Los resultados muestran un 46,62% de los adolescentes posee sobrepeso y/u obesidad. El score total de FMS fue de 14,29±2,85 y se encontraron diferencias significativas en el IMC (índice de masa corporal) p=0,000 y en el peso p=0,002 según dependencia administrativa. Existe una relación entre FMS y PC (Perímetro de cintura), IMC e ICE (índice cintura estatura) (r=-0,31**p<0,003, r=-0,14**p<0,004 y r=0,38**p<0,003 respectivamente). También se encontró que aquellos escolares que presentan riesgo cardio metabólico también ostentarían un mayor riesgo relacionado con una baja calidad de la funcionalidad motriz. Se concluye que los niveles elevados de parámetros antropométricos de riesgo cardiovascular en especial el exceso de peso y el elevado perímetro de cintura se relacionan con una deficiente funcionalidad motriz. Y por otra parte se generan problemáticas cardiovasculares en esta etapa de la vida sin mayor distinción de sexo y dependencia administraba de los colegios, lo cual hace ver que la mal nutrición y la falta de actividad física impacta de manera transversal a la sociedad. metadata Rodríguez Canales, Carolina and Hinojosa Torres, Claudio and Merellano-Navarro, Eugenio and Barraza-Gómez, Fernando and Hecht-Chau, Gernot mail carolina.rodriguez@unini.org, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2022) Funcionalidad motriz, estado nutricional e índices antropométricos de riesgo cardiometabólico en adolescentes chilenos de 12 a 15 años. Retos: nuevas tendencias en educación f\'\isica, deporte y recreación (45). pp. 400-409.

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Inglés Antimicrobial-resistant pathogenic bacteria are an increasing problem in public health, especially in the healthcare environment, where nosocomial infection microorganisms find their niche. Among these bacteria, the genus Acinetobacter which belongs to the ESKAPE pathogenic group harbors different multi-drug resistant (MDR) species that cause human nosocomial infections. Although A. baumannii has always attracted more interest, the close-related species A. pittii is the object of more study due to the increase in its isolation and MDR strains. In this work, we present the genomic analysis of five clinically isolated A. pittii strains from a Spanish hospital, with special attention to their genetic resistance determinants and plasmid structures. All the strains harbored different genes related to β-lactam resistance, as well as different MDR efflux pumps. We also found and described, for the first time in this species, point mutations that seem linked with colistin resistance, which highlights the relevance of this comparative analysis among the pathogenic species isolates. metadata Chapartegui-González, Itziar and Lázaro-Díez, María and Ramos Vivas, Jose mail UNSPECIFIED, UNSPECIFIED, jose.ramos@uneatlantico.es (2022) Genetic Resistance Determinants in Clinical Acinetobacter pittii Genomes. Antibiotics, 11 (5). p. 676. ISSN 2079-6382

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Cerrado Inglés Yersiniosis, caused by the fish pathogen Yersinia ruckeri, is a serious bacterial septicaemia affecting mainly salmonids worldwide. The acute infection may result in high mortality without apparent external disease signs, while the chronic one causes moderate to considerable mortality. Survivors of yersiniosis outbreaks become carriers. Y. ruckeri is able to adhere to, and to invade, phagocytic and non-phagocytic fish cells by using unknown molecular mechanisms. The aim of this study was to describe the kinetics of cell invasion by Y. ruckeri serotype O1 biotype 1 in a fish cell line (RTG-2) originating from rainbow trout gonads. The efficiency of invasion by Y. ruckeri was found to be temperature dependent, having a maximum at 20 °C. The bacterium was able to survive up to 96 h postinfection. The incubation of the cells at 4 °C and the pre-incubation of the bacteria with sugars or heat-inactivated antiserum significantly decreased the efficiency of invasion or even completely prevented the invasion of RTG-2 cells. These findings indicate that Y. ruckeri is capable of adhering to, entering and surviving within non-phagocytic cells, and that the intracellular environment may constitute a suitable niche for this pathogen that can favour the spread of infection and/or the maintenance of a carrier state of fish. metadata Padilla, Daniel and Acosta Hernández, Begoña and Ramos Vivas, Jose and Déniz, Soraya and Rosario, Inmaculada and Martín Barrasa, José Luís and Henao, Andrés sánchez and Silva Sergent, Freddy and Ramos Sosa, María josé and García Álvarez, Natalia and Real, Fernando mail UNSPECIFIED, UNSPECIFIED, jose.ramos@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2022) Kinetics of the invasion of a non-phagocytic fish cell line, RTG-2 by Yersinia ruckeri serotype O1 biotype 1. Acta Veterinaria Hungarica. ISSN 0236-6290

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Inglés Hafnia alvei is receiving increasing attention from both a medical and veterinary point of view, but the diversity of molecules it produces has made the interest in this bacterium extend to the field of probiotics, the microbiota, and above all, to its presence and action on consumer foods. The production of Acyl Homoserine Lactones (AHLs), a type of quorum-sensing (QS) signaling molecule, is the most often-studied chemical signaling molecule in Gram-negative bacteria. H. alvei can use this communication mechanism to promote the expression of certain enzymatic activities in fermented foods, where this bacterium is frequently present. H. alvei also produces a series of molecules involved in the modification of the organoleptic properties of different products, especially cheeses, where it shares space with other microorganisms. Although some strains of this species are implicated in infections in humans, many produce antibacterial compounds, such as bacteriocins, that inhibit the growth of true pathogens, so the characterization of these molecules could be very interesting from the point of view of clinical medicine and the food industry. Lastly, in some cases, H. alvei is responsible for the production of biogenic amines or other compounds of special interest in food health. In this article, we will review the most interesting molecules that produce the H. alvei strains and will discuss some of their properties, both from the point of view of their biological activity on other microorganisms and the properties of different food matrices in which this bacterium usually thrives. metadata Ramos Vivas, Jose and Tapia Martínez, Olga and Elexpuru Zabaleta, Maria and Tutusaus, Kilian and Armas Diaz, Yasmany and Battino, Maurizio and Giampieri, Francesca mail jose.ramos@uneatlantico.es, olga.tapia@uneatlantico.es, maria.elexpuru@uneatlantico.es, kilian.tutusaus@uneatlantico.es, UNSPECIFIED, maurizio.battino@uneatlantico.es, francesca.giampieri@uneatlantico.es (2022) The Molecular Weaponry Produced by the Bacterium Hafnia alvei in Foods. Molecules, 27 (17). p. 5585. ISSN 1420-3049

Article Subjects > Biomedicine
Subjects > Engineering Europe University of Atlantic > Research > Scientific Production
Fundación Universitaria Internacional de Colombia > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production Abierto Inglés Mobility and low energy consumption are considered the main requirements for wireless body area sensor networks (WBASN) used in healthcare monitoring systems (HMS). In HMS, battery-powered sensor nodes with limited energy are used to obtain vital statistics about the body. Hence, energy-efficient schemes are desired to maintain long-term and steady connectivity of the sensor nodes. A sheer amount of energy is consumed in activities such as idle listening, excessive transmission and reception of control messages, packet collisions and retransmission of packets, and poor path selection, that may lead to more energy consumption. A combination of adaptive scheduling with an energy-efficient protocol can help select an appropriate path at a suitable time to minimize the control overhead, energy consumption, packet collision, and excessive idle listening. This paper proposes a region-based energy-efficient multipath routing (REMR) approach that divides the entire sensor network into clusters with preferably multiple candidates to represent each cluster. The cluster representatives (CRs) route packets through various clusters. For routing, the energy requirement of each route is considered, and the path with minimum energy requirements is selected. Similarly, end-to-end delay, higher throughput, and packet-delivery ratio are considered for packet routing. metadata Akbar, Shuja and Mehdi, Muhammad Mohsin and Jamal, M. Hasan and Raza, Imran and Hussain, Syed Asad and Breñosa, Jose and Martínez Espinosa, Julio César and Pascual Barrera, Alina Eugenia and Ashraf, Imran mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, josemanuel.brenosa@uneatlantico.es, ulio.martinez@unini.edu.mx, alina.pascual@unini.edu.mx, UNSPECIFIED (2022) Multipath Routing in Wireless Body Area Sensor Network for Healthcare Monitoring. Healthcare, 10 (11). p. 2297. ISSN 2227-9032

Article Subjects > Biomedicine
Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Fundación Universitaria Internacional de Colombia > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production Cerrado Inglés Cactus has been used in traditional folk medicine because of its role in treating a number of diseases and conditions. Prickly pear fruit is an excellent source of secondary metabolites (i.e., betalains, flavonoids, and ascorbic acid) with health-promoting properties against many common human diseases, including diabetes, hypertension, hypercholesterolemia, rheumatic pain, gastric mucosa diseases and asthma. In addition, prickly pears are potential candidates for the development of low-cost functional foods because they grow with low water requirements in arid regions of the world. This review describes the main bioactive compounds found in this fruit and shows the in vitro and some clinical studies about the fruit of most important cactus (Opuntia ficus-indica) and its relationship with some chronic diseases. Even though a lot of effort have been done to study the relationship between this fruit and the human health, more studies on Opuntia ficus-indica could help better understand its pharmacological mechanism of action to provide clear scientific evidence to explain its traditional uses, and to identify its therapeutic potential in other diseases. metadata Armas Diaz, Yasmany and Machì, Michele and Salinari, Alessia and Mazas Pérez-Oleaga, Cristina and Martínez López, Nohora Milena and Briones Urbano, Mercedes and Cianciosi, Danila mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, cristina.mazas@uneatlantico.es, nohora.martinez@uneatlantico.es, mercedes.briones@uneatlantico.es, UNSPECIFIED (2022) Prickly pear fruits from "Opuntia ficus-indica" varieties as a source of potential bioactive compounds in the Mediterranean diet. Mediterranean Journal of Nutrition and Metabolism, 15 (4). pp. 581-592. ISSN 1973798X

Article Subjects > Biomedicine Ibero-american International University > Research > Scientific Production Abierto Inglés Protein-energy wasting (PEW) and poor health-related quality of life (HRQoL) are independently associated with morbi-mortality in continuous ambulatory peritoneal dialysis (CAPD). PEW may reduce HRQoL; however, we hypothesized HRQoL is affected differentially by PEW degrees or by individual criteria of nutritional status. Aim To evaluate HRQoL according to PEW severity and nutritional status indicators in CAPD. This is a cross-sectional study in 151 patients. Subjective global assessment (SGA) was employed, and nutritional status classified as normal, mild-moderate PEW, and severe PEW. HRQoL was evaluated using Kidney Disease Quality of Life Short Form™, including physical (PCS), mental (MCS) and kidney disease (KDCS) components, and their subscales. Dietary intake, anthropometric and biochemical variables were measured. Forty-six percent of patients were well-nourished, 44% had mild-moderate PEW, and 10% severe PEW. Compared with well-nourished patients, those with mild-moderate (p = 0.06) and severe (p = 0.005) PEW had lower HRQoL score [68 (52–75), 55 (45–72), 46 (43–58), respectively]. PCS, MCS, and KDCS and their subscales had lower values as PEW was more severe. Patients with obesity and hypoalbuminemia had significantly lower HRQoL overall and component scores than their counterparts. Dietary intake was not associated with quality of life. In multivariate analysis obesity, PEW (by SGA), hypoalbuminemia, and low educational level predicted poor HRQoL (χ2 58.2, p < 0.0001). As conclusion, PEW severity was related with worse HRQoL, either as overall score or in every component or subscale in CAPD patients. Poor HRQoL was predicted independently by PEW severity and obesity; additional predictors were hypoalbuminemia and low education. metadata Orozco González, Nelly and Márquez-Herrera, Roxana M. and Cortés-Sanabria, Laura and Cueto-Manzano, Alfonso M. and Gutiérrez-Medina, Margarita and Gómez-García, Erika F. and Rojas-Campos, Enrique and Paniagua-Sierra, José R. and Martín del Campo, Fabiola mail nelly.orozco@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2022) Severity of protein-energy wasting and obesity are independently related with poor quality of life in peritoneal dialysis patients. Nefrología (English Edition), 42 (2). pp. 186-195. ISSN 20132514

Article Subjects > Biomedicine
Subjects > Engineering Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production Abierto Inglés Herbal medicine and nutritional supplements are suggested to treat premenstrual somatic and psycho-behavioural symptoms in clinical guidelines; nonetheless, this is at present based on poor-quality trial evidence. Hence, we aimed to design a systematic review and meta-analysis for their effectiveness in alleviating premenstrual symptoms. The published randomized controlled trials (RCTs) were extracted from Google scholar, PubMed, Scopus and PROSPERO databases. The risk of bias in randomized trials was assessed by Cochrane risk-of-bias tool. The main outcome parameters were analysed separately based on the Premenstrual Symptom Screening Tool and PMTS and DRSP scores. Secondary parameters of somatic, psychological, and behavioural subscale symptoms of PSST were also analysed. Data synthesis was performed assuming a random-effects model, and standardized mean difference (SMDs) was analysed using SPSS version 28.0.0 (IBM, Armonk, NY, USA). A total of 754 articles were screened, and 15 RCTs were included (n = 1211 patients). Primary results for participants randomized to an intervention reported reduced PSST (n = 9), PMTS (n = 2), and DSR (n = 4) scores with (SMD = −1.44; 95% CI: −1.72 to −1.17), (SMD = −1.69; 95% CI: −3.80 to 0.42) and (SMD = 2.86; 95% CI: 1.02 to 4.69) verses comparator with substantial heterogeneity. Physical (SMD = −1.61; 95% CI = −2.56 to −0.66), behavioural (SMD = −0.60; 95% CI = −1.55 to0.35) and mood (SMD = 0.57; 95% CI = −0.96 to 2.11) subscale symptom groupings of PSST displayed similar findings. Fifty-three studies (n = 8) were considered at low risk of bias with high quality. Mild adverse events were reported by four RCTs. Based on the existing evidence, herbal medicine and nutritional supplements may be effective and safe for PMS metadata Sultana, Arshiya and Heyat, Md Belal Bin and Rahman, Khaleequr and Kunnavil, Radhika and Fazmiya, Mohamed Joonus Aynul and Akhtar, Faijan and Sumbul, X. and Vidal Mazón, Juan Luis and Rodríguez Velasco, Carmen Lilí and De La Torre Díez, Isabel mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, juanluis.vidal@uneatlantico.es, carmen.rodriguez@uneatlantico.es, UNSPECIFIED (2022) A Systematic Review and Meta-Analysis of Premenstrual Syndrome with Special Emphasis on Herbal Medicine and Nutritional Supplements. Pharmaceuticals, 15 (11). p. 1371. ISSN 1424-8247

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Inglés Objective: The objective of this paper is to review and analyze the current state of telemedicine and ehealth in the field of vascular surgery. Methods: This paper collects the relevant information obtained after reviewing the articles related to telemedicine in vascular surgery, published from 2012 to 2022 contained in scientific databases. In addition, the results obtained are statistically studied based on various factors, such as the year of publication or the search engine. In this way, we obtain a complete vision of the current state of telemedicine in the field of vascular surgery. Results: After performing this search and applying selection criteria, 29 articles were obtained for subsequent study and discussion, of which 20 were published in the second half of the decade, representing 70% of the results. In the analysis carried out according to the search criteria used, it can be seen that using the word telemedicine we obtained 69% of the articles while with the criteria mHealth and eHealth we only obtained 22% and 9% of the results, respectively. It can be seen that the filter with the most potential content articles was “vascular surgery AND telemedicine”. In the analysis performed according to the search engine, it was observed that the Google Scholar database contains 93% of the articles found in the massive search and the relevant articles contained therein represent 52% of the total. Conclusion: An upward trend has been observed in recent years, with a clear increase in the number of publications and much lower figures in the first years. One aspect to highlight is that 47.8% of the articles analyzed focus only on postoperative treatment, which may be due to the help provided by telemedicine in detecting surgical site infections by sending images and videos, this being one of the most common postoperative complications. The analyzed works show the importance of telemedicine in vascular surgery and identify possible future lines of research. In the analysis carried out on the origin of the selected relevant papers, an important interest of the US in this topic is demonstrated since more than 50% of the research contains authors from this country, it is also observed that there is no research from Spain, so this research would be an initial step to determine the weaknesses of telemedicine in this field of medicine and a good opportunity to open a research gap in this branch. metadata Herrera Montano, Isabel and Presencio Lafuente, Elena and Breñosa, Jose and Ortega-Mansilla, Arturo and Torre Díez, Isabel de la and Río-Solá, María Lourdes Del mail UNSPECIFIED, UNSPECIFIED, josemanuel.brenosa@uneatlantico.es, arturo.ortega@uneatlantico.es, UNSPECIFIED, UNSPECIFIED (2022) Systematic Review of Telemedicine and eHealth Systems Applied to Vascular Surgery. Journal of Medical Systems, 46 (12). ISSN 1573-689X

Article Subjects > Biomedicine
Subjects > Engineering Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Magazines
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production Abierto Inglés White blood cell (WBC) type classification is a task of significant importance for diagnosis using microscopic images of WBC, which develop immunity to fight against infections and foreign substances. WBCs consist of different types, and abnormalities in a type of WBC may potentially represent a disease such as leukemia. Existing studies are limited by low accuracy and overrated performance, often caused by model overfit due to an imbalanced dataset. Additionally, many studies consider a lower number of WBC types, and the accuracy is exaggerated. This study presents a hybrid feature set of selective features and synthetic minority oversampling technique-based resampling to mitigate the influence of the above-mentioned problems. Furthermore, machine learning models are adopted for being less computationally complex, requiring less data for training, and providing robust results. Experiments are performed using both machine- and deep learning models for performance comparison using the original dataset, augmented dataset, and oversampled dataset to analyze the performances of the models. The results suggest that a hybrid feature set of both texture and RGB features from microscopic images, selected using Chi2, produces a high accuracy of 0.97 with random forest. Performance appraisal using k-fold cross-validation and comparison with existing state-of-the-art studies shows that the proposed approach outperforms existing studies regarding the obtained accuracy and computational complexity. metadata Rustam, Furqan and Aslam, Naila and De La Torre Díez, Isabel and Khan, Yaser Daanial and Vidal Mazón, Juan Luis and Rodríguez Velasco, Carmen Lilí and Ashraf, Imran mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, juanluis.vidal@uneatlantico.es, carmen.rodriguez@uneatlantico.es, UNSPECIFIED (2022) White Blood Cell Classification Using Texture and RGB Features of Oversampled Microscopic Images. Healthcare, 10 (11). p. 2230. ISSN 2227-9032

Article Subjects > Biomedicine Ibero-american International University > Research > Scientific Production Abierto Inglés Background: The COVID-19 pandemic has been deadly globally; however, the most lethal outbreak worldwide occurred in Ecuador. Our work aims to highlight the pandemic's impact on the most affected countries worldwide due to the pandemic in terms of excess deaths per capita and per day. Methodology: An ecological study of all-cause mortality recorded in Ecuador during the year 2020. To calculate the total excess death relative to the historical average for the same dates in 2017, 2018 and 2019. A Poisson fitting analysis was used to identify trends on officially recorded all-caused deaths and those attributed to COVID-19. A bootstrapping technique based on central tendency measures was used to emulate the sampling distribution of our expected deaths estimator by simulating the data generation and model fitting processes on a daily basis since the first confirmed case was reported worldwide. Results: In Ecuador, during 2020, 115,070 deaths were totally reported and 42,453 were catalogued as excessive mortality when comparing with the last 3-years average (2017-2019). Ecuador is the country with the highest recorded excess mortality in the world within the shortest timespan. In one single day, Ecuador recorded 1,120 deaths (6/100,000), while Peru had 740 deaths (2/100,000) and Brazil 4,249 deaths (2/100,000). This value represents an additional 408% of the expected fatalities. The province with the highest number of excess deaths was Santa Elena on Ecuador's coast, with more than 154% increment versus previous years. Conclusions: Adjusting for population size and time, the hardest-hit country due to the COVID-19 pandemic was Ecuador. The mortality excess rate shows that the SARS-CoV-2 virus spread rapidly in the country, especially in the coastal province of Santa Elena and Guayas. Our results and the new proposed methodology could help to address the actual death toll situation during the early phase of the pandemic in Ecuador. metadata Fernández, Raúl and Vásconez-González, Jorge and Simbaña-Rivera, Katherine and Lister, Alex and Landazuri, Samanta and Castillo, Diana and Izquierdo Condoy, Juan Sebastian and Ortiz-Prado, Esteban mail UNSPECIFIED (2022) The world’s deadliest outbreak during the COVID-19 Pandemic: A proposed analytical approach to estimate Daily Excess mortality rates in Ecuador. SSRN Electronic Journal. ISSN 1556-5068

2021

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Inglés Acinetobacter baumannii is a Gram-negative coccoid rod species, clinically relevant as a human pathogen, included in the ESKAPE group. Carbapenem-resistant A. baumannii (CRAB) are considered by the World Health Organization (WHO) as a critical priority pathogen for the research and development of new antibiotics. Some of the most relevant features of this pathogen are its intrinsic multidrug resistance and its ability to acquire rapid and effective new resistant determinants against last-resort clinical antibiotics, mostly from other ESKAPE species. The presence of plasmids and mobile genetic elements in their genomes contributes to the acquisition of new antimicrobial resistance determinants. However, although A. baumannii has arisen as an important human pathogen, information about these elements is still not well understood. Current genomic analysis availability has increased our ability to understand the microevolution of bacterial pathogens, including point mutations, genetic dissemination, genomic stability, and pan- and core-genome compositions. In this work, we deeply studied the genomes of four clinical strains from our hospital, and the reference strain ATCC®19606TM, which have shown a remarkable ability to survive and maintain their effective capacity when subjected to long-term stress conditions. With that, our aim was presenting a detailed analysis of their genomes, including antibiotic resistance determinants and plasmid composition. metadata Chapartegui-González, Itziar and Lázaro-Díez, María and Redondo-Salvo, Santiago and Navas, Jesús and Ramos-Vivas, José mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, jose.ramos@uneatlantico.es (2021) Antimicrobial Resistance Determinants in Genomes and Plasmids from Acinetobacter baumannii Clinical Isolates. Antibiotics, 10 (7). p. 753. ISSN 2079-6382

Thesis Subjects > Biomedicine Ibero-american International University > Research > Doctoral Thesis Cerrado Español La enfermedad renal crónica terminal es un problema de salud a nivel mundial que afecta no solo a los pacientes con esta patología clínica sino también a su entorno; es decir, en términos generales, puede tener efectos indirectos en el ámbito familiar entre los que se encuentran el cambio de estilo de vida y la calidad de atención al paciente dializado entre otros. Aquí cabe mencionar que existen guías clínicas para el manejo adecuado de estos pacientes; sin embargo en el caso del territorio chileno, si bien existen guías clínicas, no se evidencia el uso de modelos teóricos de enfermería que consideren no solo prestaciones terapéuticas específicas de diálisis, sino también otros factores, tales como las necesidades psicológicas y sociales relacionadas con el paciente y su entorno. Objetivo: Diseñar un modelo que sirva para determinar algunos parámetros en un nuevo formato tomando como base el modelo de sistemas de Betty Neuman, el cual ayude en el quehacer diario del personal de enfermería. Método: La investigación corresponde a un estudio de caso, con diseño pre experimental. La primera etapa involucro capacitar a las enfermeras que estaban encargadas de la atención a pacientes sobre el modelo a implementar. En este sentido, se realizaron varias determinaciones como son; 1) la aplicación del cuestionario KDOQL-36 a los pacientes, antes y después de implementar el modelo. 2)Además se aplicó encuesta para medir percepción respecto a éste a enfermeras y pacientes. 3) Se realizó análisis cuantitativo mediante estadística descriptiva e inferencial utilizando el programa SPSS v.21. Resultados: La implementación de esta nueva teoría de rango medio de enfermería en la atención del paciente dializado, logró mejorar su calidad de vida, así como también permitió unir la teoría a la práctica clínica. Además se logró una apropiada aceptación de ésta por parte de los enfermeros y pacientes. metadata Ruiz Araya, Paola Andrea mail poli.andrea75@gmail.com (2021) Diseño e implementación de un modelo de atención de enfermería basado en modelo de sistemas de Betty Neuman para pacientes dializados y su familia. Doctoral thesis, UNSPECIFIED.

Article Subjects > Biomedicine Ibero-american International University > Research > Scientific Production Abierto Inglés Breast cancer (BC) is one of the most common diseases in the global population. It most commonly presents in women; however, there has been an increase in the number of men diagnosed with the disease, although at a lower rate. Its specific characteristics and associated risk factors mean that preventative measures are considered to be one of the most important methods of avoiding BC. Therefore, education is a fundamental part of this process. The objective of this study is to report on the educational interventions on BC carried out in healthcare between 2016 and 2021. To this end, an integrative review was carried out using the following databases: PubMed (NCBI), Science Direct, Scopus, SciELO and Google Scholar, using the keywords ‘breast cancer’, ‘intervention education’, ‘prevention’ and the Boolean operator ‘AND’. Quantitative, full-text articles in English, Spanish or Portuguese were included. Finally, 19 articles were selected for analysis and it was found that, with regard to educational interventions on BC carried out in healthcare, one article included men and women and the remaining 18 included only women, with interventions carried out in sessions, workshops, in stages and using dynamic techniques. Therefore, there is a pressing need for educational interventions on BC for men and women at all stages of life; however, priority should be given to the young population in order to allow for early prevention. These interventions do not generate costs for the health sector, but they have a positive effect by increasing knowledge and promoting self-care. metadata de Carmen Ortega Jiménez, Mayra and García Rodríguez, Deysi Emilia and Hidalgo Mares, Brenda and Ortega Jiménez, Marcela mail UNSPECIFIED (2021) Educational interventions on breast cancer in men and women: a necessity in primary healthcare. ecancermedicalscience, 15. ISSN 17546605

Article Subjects > Biomedicine
Subjects > Physical Education and Sport Ibero-american International University > Research > Scientific Production Abierto Español Introducción: La implementación de programas de ejercicio puede mejorar la calidad de vida de pacientes en hemodiálisis (HD). Diversos estudios hablan sobre los beneficios del ejercicio físico en estos pacientes, sin embargo, los efectos sobre marcadores antropométricos, fuerza muscular y tensión arterial (TA) según el tipo de ejercicio no han sido completamente evaluados. El objetivo de esta revisión es analizar estudios cuya intervención consistiera en la implementación de programas de ejercicio en pacientes con HD y proporcionar evidencias de sus efectos sobre los marcadores antropométricos, fuerza muscular y TA. Métodos: Se realizó una búsqueda en la literatura en Medline, LILACS, Scielo y Redalyc, con una temporalidad de 2015 a 2020. Se incluyeron 18 artículos en la presente revisión. Resultados: La combinación de ejercicio anaeróbico y de resistencia aumenta la fuerza muscular, y de igual manera, el ejercicio aeróbico y anaeróbico incrementa la fuerza muscular de las extremidades superiores e inferiores de pacientes en HD. Por otro lado, el ejercicio anaeróbico por sí solo, tiene efectos sobre los marcadores antropométricos, específicamente en el aumento de masa libre de grasa. El ejercicio aeróbico aislado es eficaz para la disminución de la TA. Conclusión: La implementación de programas de ejercicio en pacientes con HD ha demostrado tener efectos positivos sobre la fuerza muscular, los marcadores antropométricos y la TA. metadata Pérez-Jiménez, Ana Karen and Chávez-Becerril, Graciela Berenice and Orozco González, Nelly and Camacho-López, Saby mail UNSPECIFIED, UNSPECIFIED, nelly.orozco@unini.edu.mx, UNSPECIFIED (2021) Efectos del ejercicio físico sobre marcadores antropométricos, fuerza muscular y presión arterial en pacientes con hemodiálisis: una revisión narrativa. Revista de Nutrición Clínica y Metabolismo, 4 (4). pp. 98-115. ISSN 2619564X

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production Cerrado Inglés Fasting, caloric restriction and foods or compounds mimicking the biological effects of caloric restriction, known as caloric restriction mimetics, have been associated with a lower risk of age-related diseases, including cardiovascular diseases, cancer and cognitive decline, and a longer lifespan. Reduced calorie intake has been shown to stimulate cancer immunosurveillance, reducing the migration of immunosuppressive regulatory T cells towards the tumor bulk. Autophagy stimulation via reduction of lysine acetylation, increased sensitivity to chemo- and immunotherapy, along with a reduction of insulin-like growth factor 1 and reactive oxygen species have been described as some of the major effects triggered by caloric restriction. Fasting and caloric restriction have also been shown to beneficially influence gut microbiota composition, modify host metabolism, reduce total cholesterol and triglyceride levels, lower diastolic blood pressure and elevate morning cortisol level, with beneficial modulatory effects on cardiopulmonary fitness, body fat and weight, fatigue and weakness, and general quality of life. Moreover, caloric restriction may reduce the carcinogenic and metastatic potential of cancer stem cells, which are generally considered responsible of tumor formation and relapse. Here, we reviewed in vitro and in vivo studies describing the effects of fasting, caloric restriction and some caloric restriction mimetics on immunosurveillance, gut microbiota, metabolism, and cancer stem cell growth, highlighting the molecular and cellular mechanisms underlying these effects. Additionally, studies on caloric restriction interventions in cancer patients or cancer risk subjects are discussed. Considering the promising effects associated with caloric restriction and caloric restriction mimetics, we think that controlled-randomized large clinical trials are warranted to evaluate the inclusion of these non-pharmacological approaches in clinical practice. metadata Pistollato, Francesca and Forbes-Hernández, Tamara Y. and Calderón Iglesias, Rubén and Ruiz Salces, Roberto and Elexpuru Zabaleta, Maria and Dominguez Azpíroz, Irma and Cianciosi, Danila and Quiles, José L. and Giampieri, Francesca and Battino, Maurizio mail francesca.pistollato@uneatlantico.es, UNSPECIFIED, ruben.calderon@uneatlantico.es, roberto.ruiz@uneatlantico.es, maria.elexpuru@uneatlantico.es, irma.dominguez@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2021) Effects of caloric restriction on immunosurveillance, microbiota and cancer cell phenotype: Possible implications for cancer treatment. Seminars in Cancer Biology. pp. 45-57. ISSN 1044-579X

Article Subjects > Biomedicine Ibero-american International University > Research > Scientific Production Abierto Inglés Low energy pulsed electromagnetic signals (PEMS) therapy, in the field of bioelectronics, has been suggested as a promising analgesic therapy with special interest in treating conditions with poor response to pharmacotherapy. This study evaluated the effectiveness of PEMS therapy on the treatment of chronic low back pain patients with a neuropathic component. A group of 64 individuals with such condition was allocated to a 2-week treatment period (10 twenty-minute sessions on consecutive days) with an active PEMS therapy device or an inactive device in random order. The pain was assessed on a visual analog scale, and the functional status was assessed using the SF-12 questionnaire. The visual analog scale scores were lower after treatment than at baseline but only in the group treated with the active device. According to the DN4 score, neuropathic pain decreased in both experimental groups with respect to baseline, but this was only significant for the group treated with the active device. Similarly, an improvement in the SF-12 and Medical Outcomes Study (MOS) sleep scale components was reported. The study demonstrated that low-energy PEMS therapy was efficient in reducing pain and improving function in chronic low back pain patients with a neuropathic component. metadata de Teresa, Carlos and Varela-López, Alfonso and Rios-Álvarez, Susana and Gálvez, Rafael and Maire, Coralie and Gracia Villar, Santos and Battino, Maurizio and Quiles, José L. mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, santos.gracia@uneatlantico.es, maurizio.battino@uneatlantico.es, jose.quiles@uneatlantico.es (2021) Evaluation of the Analgesic Efficacy of a Bioelectronic Device in Non-Specific Chronic Low Back Pain with Neuropathic Component. A Randomized Trial. Journal of Clinical Medicine, 10 (8). p. 1781. ISSN 2077-0383

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Inglés COVID-19 declared as a pandemic that has a faster rate of infection and has impacted the lives and the country’s economy due to forced lockdowns. Its detection using RT-PCR is required long time and due to which its infection has grown exponentially. This creates havoc for the shortage of testing kits in many countries. This work has proposed a new image processing-based technique for the health care systems named “C19D-Net”, to detect “COVID-19” infection from “Chest X-Ray” (XR) images, which can help radiologists to improve their accuracy of detection COVID-19. The proposed system extracts deep learning (DL) features by applying the InceptionV4 architecture and Multiclass SVM classifier to classify and detect COVID-19 infection into four different classes. The dataset of 1900 Chest XR images has been collected from two publicly accessible databases. Images are pre-processed with proper scaling and regular feeding to the proposed model for accuracy attainments. Extensive tests are conducted with the proposed model (“C19D-Net”) and it has succeeded to achieve the highest COVID-19 detection accuracy as 96.24% for 4-classes, 95.51% for three-classes, and 98.1% for two-classes. The proposed method has outperformed well in expressions of “precision”, “accuracy”, “F1-score” and “recall” in comparison with most of the recent previously published methods. As a result, for the present situation of COVID-19, the proposed “C19D-Net” can be employed in places where test kits are in short supply, to help the radiologists to improve their accuracy of detection of COVID-19 patients through XR-Images. metadata Kaur, Prabhjot and Harnal, Shilpi and Tiwari, Rajeev and Alharithi, Fahd S. and Almulihi, Ahmed H. and Delgado Noya, Irene and Goyal, Nitin mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, irene.delgado@uneatlantico.es, UNSPECIFIED (2021) A Hybrid Convolutional Neural Network Model for Diagnosis of COVID-19 Using Chest X-ray Images. International Journal of Environmental Research and Public Health, 18 (22). p. 12191. ISSN 1660-4601

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Inglés Cancer stem cells (CSCs) are a rare tumor subpopulation with high differentiation, proliferative and tumorigenic potential compared to the remaining tumor population. CSCs were first discovered by Bonnet and Dick in 1997 in acute myeloid leukemia. The identification and isolation of these cells in this pioneering study were carried out through the flow cytometry, exploiting the presence of specific cell surface molecular markers (CD34+/CD38−). In the following years, different strategies and projects have been developed for the study of CSCs, which are basically divided into surface markers assays and functional assays; some of these techniques also allow working with a cellular model that better mimics the tumor architecture. The purpose of this mini review is to summarize and briefly describe all the current methods used for the identification, isolation and enrichment of CSCs, describing, where possible, the molecular basis, the advantages and disadvantages of each technique with a particular focus on those that offer a three-dimensional culture. metadata Cianciosi, Danila and Ansary, Johura and Forbes-Hernandez, Tamara Y. and Regolo, Lucia and Quinzi, Denise and Gracia Villar, Santos and Garcia Villena, Eduardo and Tutusaus Pifarre, Kilian and Alvarez-Suarez, José M. and Battino, Maurizio and Giampieri, Francesca mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, santos.gracia@uneatlantico.es, eduardo.garcia@uneatlantico.es, kilian.tutusaus@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2021) The Molecular Basis of Different Approaches for the Study of Cancer Stem Cells and the Advantages and Disadvantages of a Three-Dimensional Culture. Molecules, 26 (9). p. 2615. ISSN 1420-3049

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Inglés Age-related bone disorders such as osteoporosis or osteoarthritis are a major public health problem due to the functional disability for millions of people worldwide. Furthermore, fractures are associated with a higher degree of morbidity and mortality in the long term, which generates greater financial and health costs. As the world population becomes older, the incidence of this type of disease increases and this effect seems notably greater in those countries that present a more westernized lifestyle. Thus, increased efforts are directed toward reducing risks that need to focus not only on the prevention of bone diseases, but also on the treatment of persons already afflicted. Evidence is accumulating that dietary lipids play an important role in bone health which results relevant to develop effective interventions for prevent bone diseases or alterations, especially in the elderly segment of the population. This review focuses on evidence about the effects of dietary lipids on bone health and describes possible mechanisms to explain how lipids act on bone metabolism during aging. Little work, however, has been accomplished in humans, so this is a challenge for future research. metadata Romero-Márquez, Jose M. and Varela-López, Alfonso and Navarro-Hortal, María D. and Badillo-Carrasco, Alberto and Forbes-Hernández, Tamara Y. and Giampieri, Francesca and Dominguez Azpíroz, Irma and Madrigal-Hoyos, Lorena and Battino, Maurizio and Quiles, José L. mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, irma.dominguez@uneatlantico.es, lorena.madrigal@uneatlantico.es, maurizio.battino@uneatlantico.es, jose.quiles@uneatlantico.es (2021) Molecular Interactions between Dietary Lipids and Bone Tissue during Aging. International Journal of Molecular Sciences, 22 (12). p. 6473. ISSN 1422-0067

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Inglés Therapeutic bacteriophages, commonly called as phages, are a promising potential alternative to antibiotics in the management of bacterial infections of a wide range of organisms including cultured fish. Their natural immunogenicity often induces the modulation of a variated collection of immune responses within several types of immunocytes while promoting specific mechanisms of bacterial clearance. However, to achieve standardized treatments at the practical level and avoid possible side effects in cultivated fish, several improvements in the understanding of their biology and the associated genomes are required. Interestingly, a particular feature with therapeutic potential among all phages is the production of lytic enzymes. The use of such enzymes against human and livestock pathogens has already provided in vitro and in vivo promissory results. So far, the best-understood phages utilized to fight against either Gram-negative or Gram-positive bacterial species in fish culture are mainly restricted to the Myoviridae and Podoviridae, and the Siphoviridae, respectively. However, the current functional use of phages against bacterial pathogens of cultured fish is still in its infancy. Based on the available data, in this review, we summarize the current knowledge about phage, identify gaps, and provide insights into the possible bacterial control strategies they might represent for managing aquaculture-related bacterial diseases. metadata Ramos-Vivas, José and Superio, Joshua and Galindo-Villegas, Jorge and Acosta, Félix mail jose.ramos@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2021) Phage Therapy as a Focused Management Strategy in Aquaculture. International Journal of Molecular Sciences, 22 (19). p. 10436. ISSN 1422-0067

Article Subjects > Biomedicine
Subjects > Nutrition Ibero-american International University > Research > Scientific Production Abierto Inglés Protein-energy wasting (PEW) and poor health-related quality of life (HRQoL) are independently associated with morbi-mortality in continuous ambulatory peritoneal dialysis (CAPD). PEW may reduce HRQoL; however, we hypothesized HRQoL is affected differentially by PEW degrees or by individual criteria of nutritional status. Aim To evaluate HRQoL according to PEW severity and nutritional status indicators in CAPD. This is a cross-sectional study in 151 patients. Subjective global assessment (SGA) was employed, and nutritional status classified as normal, mild-moderate PEW, and severe PEW. HRQoL was evaluated using Kidney Disease Quality of Life Short Form™, including physical (PCS), mental (MCS) and kidney disease (KDCS) components, and their subscales. Dietary intake, anthropometric and biochemical variables were measured. Forty-six percent of patients were well-nourished, 44% had mild-moderate PEW, and 10% severe PEW. Compared with well-nourished patients, those with mild-moderate (p = 0.06) and severe (p = 0.005) PEW had lower HRQoL score [68 (52–75), 55 (45–72), 46 (43–58), respectively]. PCS, MCS, and KDCS and their subscales had lower values as PEW was more severe. Patients with obesity and hypoalbuminemia had significantly lower HRQoL overall and component scores than their counterparts. Dietary intake was not associated with quality of life. In multivariate analysis obesity, PEW (by SGA), hypoalbuminemia, and low educational level predicted poor HRQoL (χ2 58.2, p < 0.0001). As conclusion, PEW severity was related with worse HRQoL, either as overall score or in every component or subscale in CAPD patients. Poor HRQoL was predicted independently by PEW severity and obesity; additional predictors were hypoalbuminemia and low education. metadata Orozco González, Nelly and Márquez-Herrera, Roxana M. and Cortés-Sanabria, Laura and Cueto-Manzano, Alfonso M. and Gutiérrez-Medina, Margarita and Gómez-García, Erika F. and Rojas-Campos, Enrique and Paniagua-Sierra, José R. and Martín del Campo, Fabiola mail nelly.orozco@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2021) Severity of protein-energy wasting and obesity are independently related with poor quality of life in peritoneal dialysis patients. Nefrología. ISSN 02116995

2020

Article Subjects > Biomedicine
Subjects > Nutrition Ibero-american International University > Research > Scientific Production Cerrado Inglés Objective: The aim of this study was to validate a direct taste perception test (TPT) and evaluate its performance in patients on dialysis. Methods: This cross-sectional study was carried out in a tertiary-care hospital. A TPT was validated on 112 healthy subjects and applied on 43 patients on hemodialysis and 32 patients on peritoneal dialysis. All participants were presented a 10-mL sample to identify and rate intensity of primary tastes: sweet (sucrose 2%), sour (citric acid 0.1%), bitter (caffeine 0.06%), salty (sodium chloride 0.5%), and umami (sodium glutamate 0.25%). The internal consistency and repeatability of TPT was assessed by Cronbach's alpha and intraclass correlation coefficient. Chi-square and Mann-Whitney U tests were used to compare groups. Results: TPT had Cronbach's alpha of 0.77. Intraclass correlation coefficient was 0.74 for sweet, P < .0001; 0.57 for salty, P = .001; 0.62 for sour, P < .0001; 0.78 for bitter, P < .0001; and 0.76 for umami, P < .0001. Compared with controls, patients on peritoneal dialysis were less able to identify sweet and umami tastes (P < .05) and marginally (P = .06) sour taste, whereas patients on hemodialysis were marginally (P = .06) less able to identify sweet and salty tastes. Bitter was not differently identified between groups. According to the visual analog scale (0-10), all patients on dialysis perceived sour taste less intensely than control subjects (P < .05). Conclusions: This TPT for patients on dialysis had adequate reliability to identify five primary tastes in a clinical setting. Except for bitter taste, perception of all the primary tastes was altered in patients on dialysis compared with control subjects. A broader use of this test would help identify taste alterations and implement strategies for malnutrition. metadata Márquez-Herrera, Roxana M. and Núñez-Murillo, Gabriela K. and Ruíz-Gurrola, Claudia G. and Gómez-García, Erika F. and Orozco-González, Claudia N. and Cortes-Sanabria, Laura and Cueto-Manzano, Alfonso M. and Rojas-Campos, Enrique mail UNSPECIFIED (2020) Clinical Taste Perception Test for Patients With End-Stage Kidney Disease on Dialysis. Journal of Renal Nutrition, 30 (1). pp. 79-84. ISSN 10512276

Article Subjects > Biomedicine Ibero-american International University > Research > Scientific Production Abierto Español Objetivo: Determinar factores de riesgo para Evento cerebrovascular en jóvenes menores de 45 años en el Valle de Toluca. Metodología: Estudio transversal y correlacional. Se aplico un cuestionario para determinar los factores de riesgo para evento cerebrovascular en los adultos jóvenes. Se compararon dos grupos etarios de 18 a 32 y 33 a 45 años, mediante una U de Mann Whitney. Posteriormente se hizo un correlación de Pearson y se calculó las Odds ratio y el riesgo relativo (p < 0.05) Contribución: Se analizó 2593 encuestas, el 62% pertenece al grupo de 18 a 32 años. 68.9% presentan algún factor de riesgo bajo-medio para evento cerebrovascular. El 20% hace ejercicio más de 2:30 h. y solo el 3.4% tiene una dieta adecuada. La presencia de los factores de riesgo está relacionada con el grupo etario, en los de 33 a 45 años, las comorbilidades (sobrepeso/obesidad, hipertensión y diabetes). Mientras que el estilo de vida (tabaquismo, alcoholismo y el uso de drogas), en los menores de 32 años. Esto indica que los programas de sensibilización y capacitación deberían de dirigirse de manera diferente, de acuerdo con el grupo etario. metadata Rivera-Ramírez, Fabiola and Duarte-Troche, María del Carmen and Tenorio-Borroto, Esvieta and Orozco González, Nelly mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, nelly.orozco@unini.edu.mx (2020) Factores de riesgo para accidente cerebrovascular en adultos jóvenes. Revista de Ciencias de la Salud. pp. 1-11. ISSN 2410-3551

2019

Thesis Subjects > Biomedicine
Subjects > Physical Education and Sport
Subjects > Nutrition Ibero-american International University > Research > Doctoral Thesis Cerrado Español Actualmente la obesidad infantil es considerada como la pandemia del siglo XXI, con una alta prevalencia mundial, aumentando de 32 millones en 1990 a 41 millones en el año 2016. Es de origen multifactorial con intervención de factores genéticos, ambientales y conductuales. Está asociada a una amplia gama de complicaciones multiorgánicas graves y a un creciente riesgo de desarrollar tempranamente enfermedades crónicas no transmisibles como la diabetes mellitus y enfermedades cardiovasculares que son la principal causa de mortalidad y discapacidad en la adultez. Según la OMS, si continúa esta alta prevalencia, se estima que habrá 70 millones de niños con obesidad infantil para el año 2025. Las estrategias más efectivas de prevención son las que asocian varios componentes y para que sean más eficaces deben incorporar a la familia e iniciarse precozmente. El objetivo de esta investigación fue diseñar un Plan Estratégico de Prevención de Sobrepeso y Obesidad infantil en el Hospital General del Instituto Ecuatoriano de Seguridad Social (IESS) Quevedo, el cual, permitió brindar un tratamiento oportuno con la finalidad de prevenir las complicaciones a corto, mediano y largo plazo. Se evaluó la efectividad del Plan Estratégico mediante la validación del cuestionario con el programa informático Statistical Package for the Social Sciences (SPSS), corroborando el efecto que las intervenciones educativas tuvieron en la modificación o adquisición de hábitos alimentarios y actividad física. Se obtuvieron importantes resultados: las charlas del Club de Nutrición Infantil tuvieron una gran acogida entre los afiliados, los temas impartidos permitieron aclarar conceptos acerca de una nutrición saludable, y conocer cómo mejorar su estilo de vida. Además, se concientizó a los afiliados acerca de la importancia de disminuir el consumo de sal, azúcares refinadas y grasas saturadas, y aumentar el consumo de agua, frutas, verduras y legumbres que se pudo comprobar posterior a la intervención educativa. metadata Díaz Olmedo, Cecilia Maribel mail cm.diaz@hotmail.es (2019) Diseño de un plan estratégico para la prevención de sobrepeso y obesidad infantil en Quevedo-Ecuador. Doctoral thesis, Universidad Internacional Iberoamericana México.

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Cerrado Inglés About 1 of 10 women, particularly those older than 60 years of age, shows some degree of thyroid hormone deficiency. Thyroid diseases are generally characterized by perturbations of thyroid signaling homeostasis. The most common examples of thyroid diseases include hypothyroidism, hyperthyroidism, and several types of thyroid cancers. Phytochemicals have been shown to have either beneficial or detrimental effects on thyroid function. Some flavonoids have been reported to affect the expression and the activity of several thyroid-related enzymes and proteins, and for this reason some concerns have been raised about the possible thyroid-disruptive properties of foods enriched in these substances. On the other hand, the beneficial effects of some plant-derived compounds, such as myricetin, quercetin, apigenin, rutin, genistein, and curcumin, and their possible role as adjuvants for the treatment of thyroid cancers have been described. Here, the role of phytochemicals in thyroid signaling modulation and their possible beneficial or detrimental effects on thyroid disease risk are discussed. metadata Pistollato, Francesca and Masías Vergara, Manuel and Agudo-Toyos, Pablo and Giampieri, Francesca and Battino, Maurizio mail francesca.pistollato@uneatlantico.es, manuel.masias@uneatlantico.es, pablo.agudo@uenatlantico.es, UNSPECIFIED, UNSPECIFIED (2019) Effects of phytochemicals on thyroid function and their possible role in thyroid disease. Annals of the New York Academy of Sciences, 1443 (1). pp. 3-19. ISSN 0077-8923

Article Subjects > Biomedicine Ibero-american International University > Research > Scientific Production Abierto Español Objetivo: determinar la asociación entre el apego a la dieta y la educación nutricional en los pacientes con tratamiento de diálisis. Materiales y métodos: estudio transversal en pacientes con enfermedad renal crónica (ERC) en tratamiento de diálisis ≥6 meses, que han recibido educación nutricional previamente. Se evaluó el estado de nutrición mediante la Valoración Global Subjetiva (VGS), toma de pliegues cutáneos (tricipital y subescapular), peso seco y estatura (de acuerdo con los parámetros establecidos por la International Society for Advances of Kinanthropometry); los conocimientos nutricionales y su adherencia mediante la Encuesta de Conocimientos y Adherencia al Régimen Terapéutico, y la calidad de vida mediante el instrumento KDQOL-SF™. Resultados: se incluyeron 85 pacientes, 46 (54%) hombres y 39 (46%) mujeres con una edad media de 42 ±17 años y un tiempo medio en diálisis de 3 ± 1.96 años. El 58% de los pacientes no presentó apego al régimen dietético. Sin embargo, el 89% de los pacientes se apegaron a la recomendación de la restricción de sodio, mientras que el 59% se adhirió al consumo de líquidos. De acuerdo con la VGS, el 58% de los pacientes presentaron desnutrición leve/moderada; no obstante, el 71% tuvieron grasa promedio según la sumatoria de pliegues y el 67% presentó un estado de nutrición normal determinado por el de Índice de Masa Corporal (IMC). Conclusión: no se observó diferencia significativa en la adherencia al tratamiento dietético en aquellos pacientes que tienen conocimientos nutricionales respecto a los que no los tienen. metadata Orozco González, Nelly and Pérez-Jiménez, Ana Karen and Chávez-Becerril, Graciela Berenice mail nelly.orozco@unini.edu.mx, UNSPECIFIED, UNSPECIFIED (2019) Relación entre el apego a la dieta y la educación nutricional en pacientes con diálisis del Hospital General de Atlacomulco y el Hospital General de San Felipe del Progreso, Estado de México. Población y Salud en Mesoamérica. ISSN 1659-0201

2018

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Cerrado Inglés During the process of beeswax recycling, many industrial derivatives are obtained. These matrices may have an interesting healthy and commercial potential but to date they have not been properly studied. The aim of the present work was to evaluate the proximal and phytochemical composition, the antioxidant capacity and cytotoxic effects of two by-products from beeswax recycling process named MUD 1 and MUD 2 on liver hepatocellular carcinoma. Our results showed that MUD 1 presented the highest (P < .05) fiber, protein, carbohydrate, polyphenol and flavonoid concentration, as well as the highest (P < .05) total antioxidant capacity than the MUD 2 samples. MUD1 exerted also anticancer activity on HepG2 cells, by reducing cellular viability, increasing intracellular ROS levels and affecting mitochondrial functionality in a dose-dependent manner. We showed for the first time that by-products from beeswax recycling process can represent a rich source of phytochemicals with high total antioxidant capacity and anticancer activity; however, further researches are necessary to evaluate their potentiality for human health by in vivo studies. metadata Giampieri, Francesca and Quiles, José L. and Orantes-Bermejo, Francisco J. and Gasparrini, Massimiliano and Forbes-Hernandez, Tamara Y. and Sánchez-González, Cristina and Llopis, Juan and Rivas-García, Lorenzo and Afrin, Sadia and Varela-López, Alfonso and Cianciosi, Danila and Reboredo-Rodriguez, Patricia and Fernández-Piñar, Cristina Torres and Caderón Iglesia, Rubén and Ruiz Salces, Roberto and Aparicio Obregón, Silvia and Crespo-Álvarez, Jorge and Dzul Lopez, Luis and Xiao, Jianbo and Battino, Maurizio mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, ruben.calderon@uneatlantico.es, roberto.ruiz@uneatlantico.es, silvia.aparicio@uneatlantico.es, jorge.crespo@uneatlantico.es, luis.dzul@unini.edu.mx, UNSPECIFIED, maurizio.battino@uneatlantico.es (2018) Are by-products from beeswax recycling process a new promising source of bioactive compounds with biomedical properties? Food and Chemical Toxicology, 112. pp. 126-133. ISSN 0278-6915

Article Subjects > Biomedicine
Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Cerrado Inglés Ample epidemiological evidence suggests a strong correlation among diet, lifestyle factors and the onset and consolidation of dementia and Alzheimer’s disease (AD). It has been demonstrated that AD, diabetes, obesity, insulin resistance, and cardiovascular disease are strongly interconnected pathologies. Preventive strategies and nutritional interventions seem to be promising approaches to delay neurocognitive decline and reduce the risk of AD and other non-psychiatric co-morbidities. In this regard, healthy dietary patterns, characterized by high intake of plant-based foods, probiotics, antioxidants, soy beans, nuts, and omega-3 polyunsaturated fatty acids, and a low intake of saturated fats, animal-derived proteins, and refined sugars, have been shown to decrease the risk of neurocognitive impairments and eventually the onset of AD. Here we review the role of some nutrients and, in particular, of healthy dietary patterns, such as the Mediterranean diet and other emerging healthy diets, DASH (Dietary Approach to Stop Hypertension) and MIND (Mediterranean-DASH dietIntervention for Neurodegenerative Delay), for the maintenance of cognitive performance, focusing specifically on human studies. The beneficial effects associated with overall diet composition, rather than single nutrient supplementations, for the prevention or the delay of AD and dementia are discussed. metadata Pistollato, Francesca and Calderón Iglesias, Rubén and Ruiz Salces, Roberto and Aparicio-Obregón, Silvia and Crespo-Álvarez, Jorge and Dzul Lopez, Luis Alonso and Manna, Piera Pia and Giampieri, Francesca and Battino, Maurizio mail francesca.pistollato@uneatlantico.es, ruben.calderon@uneatlantico.es, roberto.ruiz@uneatlantico.es, silvia.aparicio@uneatlantico.es, jorge.crespo@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2018) Nutritional patterns associated with the maintenance of neurocognitive functions and the risk of dementia and Alzheimer’s disease: A focus on human studies. Pharmacological Research, 131. pp. 32-43. ISSN 10436618

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Cerrado Inglés A protracted pro-inflammatory state is the common denominator in the development, progression and complication of the common chronic diseases. Dietary antioxidants represent an efficient tool to counteract this inflammatory state. The aim of the present work was to evaluate the effects of strawberry extracts on inflammation evoked by E. Coli lipopolysaccharide in Human Dermal Fibroblast, by measuring reactive oxygen species production, apoptosis rate, antioxidant enzymes activity, mitochondria functionality and also investigating the molecular pathway involved in inflammatory and antioxidant response. The results demonstrated that strawberry pre-treatment reduced intracellular reactive oxygen species levels, apoptotic rate, improved antioxidant defences and mitochondria functionality in lipopolysaccharide -treated cells. Strawberry exerted these protective activities through the inhibition of the NF-kB signalling pathway and the stimulation of the Nrf2 pathway, with a mechanism AMPK-dependent. These results confirm the health benefits of strawberry in the prevention of inflammation and oxidative stress condition in lipopolysaccharide-treated cells. metadata Gasparrini, Massimiliano and Giampieri, Francesca and Forbes-Hernandez, Tamara Y. and Afrin, Sadia and Cianciosi, Danila and Reboredo-Rodriguez, Patricia and Varela-Lopez, Alfonso and Zhang, JiaoJiao and Quiles, Josè L. and Mezzetti, Bruno and Bompadre, Stefano and Battino, Maurizio mail UNSPECIFIED, UNSPECIFIED, tamara.forbes@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2018) Strawberry extracts efficiently counteract inflammatory stress induced by the endotoxin lipopolysaccharide in Human Dermal Fibroblast. Food and Chemical Toxicology, 114. pp. 128-140. ISSN 0278-6915

2017

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Cerrado Inglés A common denominator in the pathogenesis of most chronic inflammatory diseases is the involvement of oxidative stress, related to ROS production by all aerobic organisms. Dietary antioxidants from plant foods represent an efficient strategy to counteract this condition. The aim of the present study was to evaluate the protective effects of strawberry extracts on inflammatory status induced by E. Coli LPS on RAW 264.7 macrophages by measuring the main oxidative and inflammatory biomarkers and investigating the molecular pathways involved. Strawberry pre-treatment efficiently counteracted LPS-induced oxidative stress reducing the amount of ROS and nitrite production, stimulating endogenous antioxidant enzyme activities and enhancing protection against lipid, protein and DNA damage (P < 0.05). Strawberry pre-treatment exerted these protective effects primarily through the activation of the Nrf2 pathway, which is markedly AMPK-dependent and also by the modulation of the NF-kB signalling pathway. Finally, an improvement in mitochondria functionality was also detected. The results obtained in this work highlight the health benefit of strawberries against inflammatory and oxidative stress in LPS-stimulated RAW 264.7 macrophages, investigating for the first time the possible involved molecular mechanisms. metadata Gasparrini, Massimiliano and Forbes-Hernandez, Tamara Y. and Giampieri, Francesca and Afrin, Sadia and Alvarez-Suarez, Josè M. and Mazzoni, Luca and Mezzetti, Bruno and Quiles, Josè L. and Battino, Maurizio mail UNSPECIFIED, tamara.forbes@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2017) Anti-inflammatory effect of strawberry extract against LPS-induced stress in RAW 264.7 macrophages. Food and Chemical Toxicology, 102. pp. 1-10. ISSN 0278-6915

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Inglés Regulation of lipid metabolism is essential for treatment and prevention of several chronic diseases such as obesity, diabetes, and cardiovascular diseases, which are responsible for most deaths worldwide. It has been demonstrated that the AMP-activated protein kinase (AMPK) has a direct impact on lipid metabolism by modulating several downstream-signaling components. The main objective of the present work was to evaluate the in vitro effect of a methanolic strawberry extract on AMPK and its possible repercussion on lipid metabolism in human hepatocellular carcinoma cells (HepG2). For such purpose, the lipid profile and the expression of proteins metabolically related to AMPK were determined on cells lysates. The results demonstrated that strawberry methanolic extract decreased total cholesterol, low-density lipoprotein (LDL)-cholesterol, and triglycerides levels (up to 0.50-, 0.30-, and 0.40-fold, respectively) while it stimulated the p-AMPK/AMPK expression (up to 3.06-fold), compared to the control. AMPK stimulation led to the phosphorylation and consequent inactivation of acetyl coenzyme A carboxylase (ACC) and inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the major regulators of fatty acids and cholesterol synthesis, respectively. Strawberry treatment also entailed a 4.34-, 2.37-, and 2.47-fold overexpression of LDL receptor, sirtuin 1 (Sirt1), and the peroxisome proliferator activated receptor gamma coactivator 1-alpha (PGC-1α), respectively, compared to control. The observed results were counteracted by treatment with compound C, an AMPK pharmacological inhibitor, confirming that multiple effects of strawberries on lipid metabolism are mediated by the activation of this protein. metadata Forbes-Hernandez, Tamara Y. and Giampieri, Francesca and Gasparrini, Massimiliano and Afrin, Sadia and Mazzoni, Luca and Cordero, Mario and Mezzetti, Bruno and Quiles, José L. and Battino, Maurizio mail tamara.forbes@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2017) Lipid Accumulation in HepG2 Cells Is Attenuated by Strawberry Extract through AMPK Activation. Nutrients, 9 (6). p. 621. ISSN 2072-6643

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Inglés A protracted pro-inflammatory state is a major contributing factor in the development, progression and complication of the most common chronic pathologies. Fruit and vegetables represent the main sources of dietary antioxidants and their consumption can be considered an efficient tool to counteract inflammatory states. In this context an evaluation of the protective effects of strawberry extracts on inflammatory stress induced by E. coli LPS on human dermal fibroblast cells was performed in terms of viability assays, ROS and nitrite production and biomarkers of oxidative damage of the main biological macromolecules. The results demonstrated that strawberry extracts exerted an anti-inflammatory effect on LPS-treated cells, through an increase in cell viability, and the reduction of ROS and nitrite levels, and lipid, protein and DNA damage. This work showed for the first time the potential health benefits of strawberry extract against inflammatory and oxidative stress in LPS-treated human dermal fibroblast cells. metadata Gasparrini, Massimiliano and Forbes-Hernandez, Tamara Y. and Giampieri, Francesca and Afrin, Sadia and Mezzetti, Bruno and Quiles, José L. and Bompadre, Stefano and Battino, Maurizio mail UNSPECIFIED, tamara.forbes@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2017) Protective Effect of Strawberry Extract against Inflammatory Stress Induced in Human Dermal Fibroblasts. Molecules, 22 (1). p. 164. ISSN 1420-3049

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Inglés Dyslipidemia and oxidation of low density lipoproteins (LDL) are recognized as critical factors in the development of atherosclerosis. Healthy dietary patterns, with abundant fruit and vegetable consumption, may prevent the onset of these risk factors due to the presence of phytochemical compounds. Strawberries are known for their high content of polyphenols; among them, flavonoids are the major constituents, and it is presumed that they are responsible for the biological activity of the fruit. Nevertheless, there are only a few studies that actually evaluate the effects of different fractions isolated from strawberries. In order to assess the effects of two different strawberry extracts (whole methanolic extract/anthocyanin-enriched fraction) on the lipid profile and antioxidant status in human hepatocellular carcinoma (HepG2) cells, the triglycerides and LDL-cholesterol content, lipid peroxidation, intracellular reactive oxygen species (ROS) content and antioxidant enzymes’ activity on cell lysates were determined. Results demonstrated that both strawberry extracts not only improved the lipid metabolism by decreasing triglycerides and LDL-cholesterol contents, but also improved the redox state of HepG2 cells by modulating thiobarbituric acid-reactive substances production, antioxidant enzyme activity and ROS generation. The observed effects were more pronounced for the anthocyanin-enriched fraction. metadata Forbes-Hernandez, Tamara Y. and Gasparrini, Massimiliano and Afrin, Sadia and Cianciosi, Danila and González-Paramás, Ana and Santos-Buelga, Celestino and Mezzetti, Bruno and Quiles, José L. and Battino, Maurizio and Giampieri, Francesca and Bompadre, Stefano mail tamara.forbes@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es, UNSPECIFIED, UNSPECIFIED (2017) Strawberry (cv. Romina) Methanolic Extract and Anthocyanin-Enriched Fraction Improve Lipid Profile and Antioxidant Status in HepG2 Cells. International Journal of Molecular Sciences, 18 (6). p. 1149. ISSN 1422-0067

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Inglés Extreme exposure of skin to Ultraviolet A (UVA)-radiation may induce a dysregulated production of reactive oxygen species (ROS) which can interact with cellular biomolecules leading to oxidative stress, inflammation, DNA damage, and alteration of cellular molecular pathways, responsible for skin photoaging, hyperplasia, erythema, and cancer. For these reasons, the use of dietary natural bioactive compounds with remarkable antioxidant activity could be a strategic tool to counteract these UVA-radiation-caused deleterious effects. Thus, the purpose of the present work was to test the efficacy of strawberry (50 μg/mL)-based formulations supplemented with Coenzyme Q10 (100 μg/mL) and sun protection factor 10 in human dermal fibroblasts irradiated with UVA-radiation. The apoptosis rate, the amount of intracellular reactive oxygen species (ROS) production, the expression of proteins involved in antioxidant and inflammatory response, and mitochondrial functionality were evaluated. The results showed that the synergic topical use of strawberry and Coenzyme Q10 provided a significant (p < 0.05) photoprotective effect, reducing cell death and ROS, increasing antioxidant defense, lowering inflammatory markers, and improving mitochondrial functionality. The obtained results suggest the use of strawberry-based formulations as an innovative, natural, and useful tool for the prevention of UVA exposure-induced skin diseases in order to decrease or substitute the amount of synthetic sunscreen agents. metadata Gasparrini, Massimiliano and Forbes-Hernandez, Tamara Y. and Afrin, Sadia and Reboredo-Rodriguez, Patricia and Cianciosi, Danila and Mezzetti, Bruno and Quiles, José L. and Bompadre, Stefano and Battino, Maurizio and Giampieri, Francesca mail UNSPECIFIED, tamara.forbes@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es, UNSPECIFIED (2017) Strawberry-Based Cosmetic Formulations Protect Human Dermal Fibroblasts against UVA-Induced Damage. Nutrients, 9 (6). p. 605. ISSN 2072-6643

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Cerrado Inglés It is generally accepted that a fruit and vegetable–enriched diet is favorable for human health. The consumption of strawberries, in particular, has been related to the maintenance of well-being and the prevention of several chronic diseases, owing to the high contents of antioxidants and phytochemicals present in the fruit. Several biological effects have been explained through the total antioxidant capacity exerted by these bioactive compounds, but recently more intricate mechanisms have begun to be examined. In this context, it has been reported that strawberry phenolics are able to exert anti-inflammatory, anticarcinogenic, antiproliferative, and antiatherosclerotic activities, acting on specific molecular pathways related to antioxidant defenses, metabolism, survival, and proliferation. The overall aim of this work is to discuss and update the cellular and molecular mechanisms recently proposed to clarify the effects of strawberry phenolics on human health, with particular attention to the most common chronic diseases, such as metabolic syndrome, cardiovascular disease, and cancer. metadata Giampieri, Francesca and Forbes-Hernandez, Tamara Y. and Gasparrini, Massimiliano and Afrin, Sadia and Cianciosi, Danila and Reboredo-Rodriguez, Patricia and Varela-Lopez, Alfonso and Quiles, Jose L. and Mezzetti, Bruno and Battino, Maurizio mail UNSPECIFIED, tamara.forbes@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2017) The healthy effects of strawberry bioactive compounds on molecular pathways related to chronic diseases. Annals of the New York Academy of Sciences, 1398 (1). pp. 62-71. ISSN 0077-8923

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Cerrado Inglés Among gynaecological cancers, ovarian cancer represents the leading cause of death in women. Current treatment for ovarian cancer entails surgery followed by combined chemotherapy with platinum and taxane, which are associated, particularly cisplatin, with severe side effects. While this treatment approach appears to be initially effective in a high number of patients, nearly 70% of them suffer a relapse within a few months after initial treatment. Therefore, more effective and better-tolerated treatment options are clearly needed. In recent years, several natural compounds (such as curcumin, epigallocatechin 3-gallate (EGCG), resveratrol, sulforaphane and Withaferin-A), characterized by long-term safety and negligible and/or inexistent side effects, have been proposed as possible adjuvants of traditional chemotherapy. Indeed, several in vitro and in vivo studies have shown that phytocompounds can effectively inhibit tumor cell proliferation, stimulate autophagy, induce apoptosis, and specifically target ovarian cancer stem cells (CSCs), which are generally considered to be responsible for tumor recurrence in several types of cancer. Here we review current literature on the role of natural products in ovarian cancer chemoprevention, highlighting their effects particularly on the regulation of inflammation, autophagy, proliferation and apoptosis, chemotherapy resistance, and ovarian CSC growth. metadata Pistollato, Francesca and Calderón Iglesias, Rubén and Ruiz Salces, Roberto and Aparicio Obregón, Silvia and Crespo Alvare, Jorge and Dzul Lopez, Luis and Giampieri, Francesca and Battino, Maurizio mail UNSPECIFIED, ruben.calderon@uneatlantico.es, roberto.ruiz@uneatlantico.es, silvia.aparicio@uneatlantico.es, jorge.crespo@uneatlantico.es, luis.dzul@unini.edu.mx, UNSPECIFIED, maurizio.battino@uneatlantico.es (2017) The use of natural compounds for the targeting and chemoprevention of ovarian cancer. Cancer Letters, 411. pp. 191-200. ISSN 0304-3835

2016

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Cerrado Inglés Doxorubicin (Dox), one of the most used chemotherapeutic agents, is known to generate oxidative stress and block DNA synthesis, which result in severe dose-limiting toxicity. A strategy to protect against Dox toxic effects could be to use dietary antioxidants of which fruits and vegetable are a rich source. In this context, strawberry consumption is associated with the maintenance of good health and the prevention of several diseases, thanks to the antioxidant capacities of its bioactive compounds. The aim of the present study was to evaluate the protective effects of strawberry consumption against oxidative stress induced by Dox in rats. Animals were fed with strawberry enriched diet (15% of the total calories) for two months and Dox (10 mg/kg; i.p.) was injected at the end of the experimental period. Strawberry consumption significantly inhibited ROS production and oxidative damage biomarkers accumulation in plasma and liver tissue and alleviated histopathological changes in rat livers treated with Dox. The reduction of antioxidant enzyme activities was significantly mitigated after strawberry consumption. In addition, strawberry enriched diet ameliorated liver mitochondrial antioxidant levels and functionality. In conclusion, strawberry intake protects against Dox-induced toxicity, at plasma, liver and mitochondrial levels thanks to its high contents of bioactive compounds. metadata Giampieri, Francesca and Alvarez-Suarez, Jose M. and Gasparrini, Massimiliano and Forbes- Hernandez, Tamara Y. and Afrin, Sadia and Bompadre, Stefano and Rubini, Corrado and Zizzi, Antonio and Astolfi, Paola and Santos-Buelga, Celestino and González-Paramás, Ana M. and Quiles, Josè L. and Mezzetti, Bruno and Battino, Maurizio mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, tamara.forbes@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2016) Strawberry consumption alleviates doxorubicin-induced toxicity by suppressing oxidative stress. Food and Chemical Toxicology, 94. pp. 128-137. ISSN 0278-6915

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Cerrado Inglés Glioblastoma multiforme (GBM) are extremely lethal and still poorly treated primary brain tumors, characterized by the presence of highly tumorigenic cancer stem cell (CSC) subpopulations, considered responsible for tumor relapse. In order to successfully eradicate GBM growth and recurrence, new anti-cancer strategies selectively targeting CSCs should be designed. CSCs might be eradicated by targeting some of their cell surface markers and transporters, inducing their differentiation, impacting their hyper-glycolytic metabolism, inhibiting CSC-related signaling pathways and/or by targeting their microenvironmental niche. In this regard, phytocompounds such as curcumin, isothiocyanates, resveratrol and epigallocatechin-3-gallate have been shown to prevent or reverse cancer-related epigenetic dysfunctions, reducing tumorigenesis, preventing metastasis and/or increasing chemotherapy and radiotherapy efficacy. However, the actual bioavailability and metabolic processing of phytocompounds is generally unknown, and the presence of the blood brain barrier often represents a limitation to glioma treatments. Nowadays, nanoparticles (NPs) can be loaded with therapeutic compounds such as phytochemicals, improving their bioavailability and their targeted delivery within the GBM tumor bulk. Moreover, NPs can be designed to increase their tropism and specificity toward CSCs by conjugating their surface with antibodies specific for CSC antigens, with ligands or with glucose analogues. Here we discuss the use of phytochemicals as anti-glioma agents and the applicability of phytochemical-loaded NPs as drug delivery systems to target GBM. Additionally, we provide some examples on how NPs can be specifically formulated to improve CSC targeting. metadata Pistollato, Francesca and Bremer-Hoffmann, Susanne and Basso, Giuseppe and Sumalla Cano, Sandra and Elío Pascual, Iñaki and Masías Vergara, Manuel and Giampieri, Francesca and Battino, Maurizio mail francesca.pistollato@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, sandra.sumalla@uneatlantico.es, inaki.elio@uneatlantico.es, manuel.masias@uneatlantico.es, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es (2016) Targeting Glioblastoma with the Use of Phytocompounds and Nanoparticles. Targeted Oncology, 11 (1). pp. 1-16. ISSN 1776-2596

2015

Article Subjects > Biomedicine Ibero-american International University > Research > Scientific Production Abierto Inglés Strawberry polyphenols have been extensively studied over the last two decades for their beneficial properties. Recently, their possible use in ameliorating skin conditions has also been proposed; however, their role in preventing UVA-induced damage in cosmetic formulation has not yet been investigated. Skin is constantly exposed to several environmental stressors, such as UVA radiation, that induce oxidative stress, inflammation and cell death via the production of reactive oxygen species (ROS). In the present study, we assessed the potential photoprotective capacity of different strawberry-based formulations, enriched with nanoparticles of Coenzyme Q10 and with sun protection factor 10 (SPF10), in human dermal fibroblasts (HuDe) exposed to UVA radiation. We confirmed that strawberries are a very rich source of polyphenols, anthocyanins and vitamins, and possess high total antioxidant capacity. We also showed that strawberry extracts (25 μg/mL–1 mg/mL) exert a noticeable photoprotection in HuDe, increasing cell viability in a dose-dependent way, and that these effects are potentiated by the presence of CoQ10red (100 μg/mL). We have demonstrated for the first time that the topical use of strawberry extract may provide good photoprotection, even if more in-depth studies are strongly encouraged in order to evaluate the cellular and molecular effects of strawberry protection. metadata Gasparrini, Massimiliano and Forbes-Hernandez, Tamara Y. and Afrin, Sadia and Alvarez-Suarez, José and Gonzàlez-Paramàs, Ana and Santos-Buelga, Celestino and Bompadre, Stefano and Quiles, José and Mezzetti, Bruno and Giampieri, Francesca mail UNSPECIFIED, tamara.forbes@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2015) A Pilot Study of the Photoprotective Effects of Strawberry-Based Cosmetic Formulations on Human Dermal Fibroblasts. International Journal of Molecular Sciences, 16 (8). pp. 17870-17884. ISSN 1422-0067

Article Subjects > Biomedicine
Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Cerrado Inglés In the last decade, specific dietary patterns, mainly characterized by high consumption of vegetables and fruits, have been proven beneficial for the prevention of both metabolic syndrome (MetS)-related dysfunctions and neurodegenerative disorders, such as Alzheimer’s disease (AD). Nowadays, neuroimaging readouts can be used to diagnose AD, investigate MetS effects on brain functionality and anatomy, and assess the effects of dietary supplementations and nutritional patterns in relation to neurodegeneration and AD-related features. Here we review scientific literature describing the use of the most recent neuroimaging techniques to detect AD- and MetS-related brain features, and also to investigate associations between consolidated dietary patterns or nutritional interventions and AD, specifically focusing on observational and intervention studies in humans. metadata Pistollato, Francesca and Sumalla Cano, Sandra and Elío Pascual, Iñaki and Masías Vergara, Manuel and Giampieri, Francesca and Battino, Maurizio mail francesca.pistollato@uneatlantico.es, sandra.sumalla@uneatlantico.es, inaki.elio@uneatlantico.es, manuel.masias@uneatlantico.es, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es (2015) The Use of Neuroimaging to Assess Associations Among Diet, Nutrients, Metabolic Syndrome, and Alzheimer’s Disease. Journal of Alzheimer's Disease, 48 (2). pp. 303-318. ISSN 13872877

This list was generated on Fri Sep 22 23:41:12 2023 UTC.

Can the phenolic compounds of Manuka honey chemosensitize colon cancer stem cells? A deep insight into the effect on chemoresistance and self-renewal

Manuka honey, which is rich in pinocembrin, quercetin, naringenin, salicylic, p-coumaric, ferulic, syringic and 3,4-dihydroxybenzoic acids, has been shown to have pleiotropic effects against colon cancer cells. In this study, potential chemosensitizing effects of Manuka honey against 5-Fluorouracil were investigated in colonspheres enriched with cancer stem cells (CSCs), which are responsible for chemoresistance. Results showed that 5-Fluorouracil increased when it was combined with Manuka honey by downregulating the gene expression of both ATP-binding cassette sub-family G member 2, an efflux pump and thymidylate synthase, the main target of 5-Fluorouracil which regulates the ex novo DNA synthesis. Manuka honey was associated with decreased self-renewal ability by CSCs, regulating expression of several genes in Wnt/β-catenin, Hedgehog and Notch pathways. This preliminary study opens new areas of research into the effects of natural compounds in combination with pharmaceuticals and, potentially, increase efficacy or reduce adverse effects.

Producción Científica

Danila Cianciosi mail , Yasmany Armas Diaz mail , José M. Alvarez-Suarez mail , Xiumin Chen mail , Di Zhang mail , Nohora Milena Martínez López mail nohora.martinez@uneatlantico.es, Mercedes Briones Urbano mail mercedes.briones@uneatlantico.es, José L. Quiles mail jose.quiles@uneatlantico.es, Adolfo Amici mail , Maurizio Battino mail maurizio.battino@uneatlantico.es, Francesca Giampieri mail francesca.giampieri@uneatlantico.es,

Cianciosi

open

Voxel Extraction and Multiclass Classification of Identified Brain Regions across Various Stages of Alzheimer’s Disease Using Machine Learning Approaches

This study sought to investigate how different brain regions are affected by Alzheimer’s disease (AD) at various phases of the disease, using independent component analysis (ICA). The study examines six regions in the mild cognitive impairment (MCI) stage, four in the early stage of Alzheimer’s disease (AD), six in the moderate stage, and six in the severe stage. The precuneus, cuneus, middle frontal gyri, calcarine cortex, superior medial frontal gyri, and superior frontal gyri were the areas impacted at all phases. A general linear model (GLM) is used to extract the voxels of the previously mentioned regions. The resting fMRI data for 18 AD patients who had advanced from MCI to stage 3 of the disease were obtained from the ADNI public source database. The subjects include eight women and ten men. The voxel dataset is used to train and test ten machine learning algorithms to categorize the MCI, mild, moderate, and severe stages of Alzheimer’s disease. The accuracy, recall, precision, and F1 score were used as conventional scoring measures to evaluate the classification outcomes. AdaBoost fared better than the other algorithms and obtained a phenomenal accuracy of 98.61%, precision of 99.00%, and recall and F1 scores of 98.00% each.

Producción Científica

Samra Shahzadi mail , Naveed Anwer Butt mail , Muhammad Usman Sana mail , Iñaki Elío Pascual mail inaki.elio@uneatlantico.es, Mercedes Briones Urbano mail mercedes.briones@uneatlantico.es, Isabel de la Torre Díez mail , Imran Ashraf mail ,

Shahzadi

open

Adaptive Filtering: Issues, Challenges, and Best-Fit Solutions Using Particle Swarm Optimization Variants

Adaptive equalization is crucial in mitigating distortions and compensating for frequency response variations in communication systems. It aims to enhance signal quality by adjusting the characteristics of the received signal. Particle swarm optimization (PSO) algorithms have shown promise in optimizing the tap weights of the equalizer. However, there is a need to enhance the optimization capabilities of PSO further to improve the equalization performance. This paper provides a comprehensive study of the issues and challenges of adaptive filtering by comparing different variants of PSO and analyzing the performance by combining PSO with other optimization algorithms to achieve better convergence, accuracy, and adaptability. Traditional PSO algorithms often suffer from high computational complexity and slow convergence rates, limiting their effectiveness in solving complex optimization problems. To address these limitations, this paper proposes a set of techniques aimed at reducing the complexity and accelerating the convergence of PSO.

Producción Científica

Arooj Khan mail , Imran Shafi mail , Sajid Gul Khawaja mail , Isabel de la Torre Díez mail , Miguel Ángel López Flores mail miguelangel.lopez@uneatlantico.es, Juan Castanedo Galán mail juan.castanedo@uneatlantico.es, Imran Ashraf mail ,

Khan

open

Empowering Lower Limb Disorder Identification through PoseNet and Artificial Intelligence

A novel approach is presented in this study for the classification of lower limb disorders, with a specific emphasis on the knee, hip, and ankle. The research employs gait analysis and the extraction of PoseNet features from video data in order to effectively identify and categorize these disorders. The PoseNet algorithm facilitates the extraction of key body joint movements and positions from videos in a non-invasive and user-friendly manner, thereby offering a comprehensive representation of lower limb movements. The features that are extracted are subsequently standardized and employed as inputs for a range of machine learning algorithms, such as Random Forest, Extra Tree Classifier, Multilayer Perceptron, Artificial Neural Networks, and Convolutional Neural Networks. The models undergo training and testing processes using a dataset consisting of 174 real patients and normal individuals collected at the Tehsil Headquarter Hospital Sadiq Abad. The evaluation of their performance is conducted through the utilization of K-fold cross-validation. The findings exhibit a notable level of accuracy and precision in the classification of various lower limb disorders. Notably, the Artificial Neural Networks model achieves the highest accuracy rate of 98.84%. The proposed methodology exhibits potential in enhancing the diagnosis and treatment planning of lower limb disorders. It presents a non-invasive and efficient method of analyzing gait patterns and identifying particular conditions.

Producción Científica

Hafeez Ur Rehman Siddiqui mail , Adil Ali Saleem mail , Muhammad Amjad Raza mail , Santos Gracia Villar mail santos.gracia@uneatlantico.es, Luis Dzul Lopez mail luis.dzul@unini.edu.mx, Isabel de la Torre Diez mail , Furqan Rustam mail , Sandra Dudley mail ,

Siddiqui

open

Real Word Spelling Error Detection and Correction for Urdu Language

Non-word and real-word errors are generally two types of spelling errors. Non-word errors are misspelled words that are nonexistent in the lexicon while real-word errors are misspelled words that exist in the lexicon but are used out of context in a sentence. Lexicon-based lookup approach is widely used for non-word errors but it is incapable of handling real-word errors as they require contextual information. Contrary to the English language, real-word error detection and correction for low-resourced languages like Urdu is an unexplored area. This paper presents a real-word spelling error detection and correction approach for the Urdu language. We develop an extensive lexicon of 593,738 words and use this lexicon to develop a dataset for real-word errors comprising 125562 sentences and 2,552,735 words. Based on the developed lexicon and dataset, we then develop a contextual spell checker that detects and corrects real-word errors. For the real-word error detection phase, word-gram features are used along with five machine learning classifiers, achieving a precision, recall, and F1-score of 0.84,0.79, and 0.81 respectively. We also test the proposed approach with a 40% error density. For real-word error correction, the Damerau-Levenshtein distance is used along with the n-gram model for further ranking of the suggested candidate words, achieving an accuracy of up to 83.67%.

Producción Científica

Romila Aziz mail , Muhammad Waqas Anwar mail , Muhammad Hasan Jamal mail , Usama Ijaz Bajwa mail , Ángel Gabriel Kuc Castilla mail , Carlos Uc-Rios mail carlos.uc@unini.edu.mx, Ernesto Bautista Thompson mail ernesto.bautista@unini.edu.mx, Imran Ashraf mail ,

Aziz

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