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2022

Article Subjects > Biomedicine Ibero-american International University > Research > Scientific Production Abierto Inglés Objective: Women with gynecologic cancer may sufer from pelvic foor dysfunction (PFD). Before radiotherapy, prehabilitation with pelvic foor muscle exercises (PFME) and vaginal dilator (VD) might prevent it and foster sexual life. This study aims to explore the experience of gynecologic cancer patients getting external beam radiation treatments regarding barriers to and facilitators of adherence to a prehabilitation program to prevent PFD. Methods: This qualitative research with thematic content analysis included 11 women with gynecologic cancer and diferent levels of adherence to PFME and VD. Participants were interviewed based on a semi-structured script. The information was analyzed manually, assisted with Nvivo12® software, and triangulated with open coding. Results: High self-motivation, desire to improve their health, symptoms of improvement, availability of time, the desire to resume sexual life, and the support of the partner were facilitators of adherence. The instructional exercise audio, clarity of the information, and closer communication with the physical therapist were also valued. The main barriers were general malaise secondary to oncological treatments, forgetfulness, lack of time, misinformation, lack of coordination with the treatment team, discomfort with the VD, and a feeling of shame. Feedback from the attending physician was a facilitator when present or a barrier when absent. Conclusion: These barriers and facilitators should be considered when designing and implementing preventive programs with PFME and VD. Behavioral counselling should consider the desire to remain sexually active; in such cases, including the partner in the therapeutic process is appraised. Otherwise, the focus should be on benefts for maintenance of pelvic foor function. metadata Araya, Paulina and Roa-Alcaino, Sonia and Celedón, Claudia and Cuevas-Said, Mónica and de Sousa Dantas, Diego and Sacomori, Cinara mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, csacomori@yahoo.com.br (2022) Barriers to and facilitators of adherence to pelvic floor muscle exercises and vaginal dilator use among gynecologic cancer patients: a qualitative study. Supportive Care in Cancer. ISSN 0941-4355

Article Subjects > Biomedicine
Subjects > Nutrition
Ibero-american International University > Research > Scientific Production Abierto Español Introducción: el objetivo del presente trabajo se centra en reconocer la importancia de las investigaciones que relacionan la biodisponibilidad de fósforo en diferentes grupos de alimentos de origen animal, vegetal e industrial y su efecto en la progresión de la enfermedad renal crónica (ERC). Metodología: la revisión se sustentó en la búsqueda literaria en páginas web como PUBMED, Redalyc, SciELO, SCIHUB y Google Academic. Se seleccionó cada estudio, descartando aquellos que no fueran cuantitativos u originales, estuvieran incompletos, sin metodología clara, realizados en mamíferos o si los resultados no se especificaban en porcentajes. La lectura puso especial énfasis en el índice de biodisponibilidad de fósforo derivado del consumo de distintos productos alimenticios. Se elaboraron tres matrices de acuerdo con el origen del comestible y la biodisponibilidad de fósforo que absorbe el organismo. Resultados: se encontró que los alimentos industrializados y los aditivos muestran una biodisponibilidad de fósforo del 90 % al 100 %, los de origen animal del 40 % al 80 % y los de origen vegetal del 30 %. Conclusiones: los aditivos de los alimentos industrializados promueven la hiperfosfatemia y, con ello, aceleran la progresión de la enfermedad renal crónica, a diferencia de los de origen animal y vegetal, menos perjudiciales para la salud. Esto da pauta a la formación del sector salud para ampliar su conocimiento sobre el tratamiento nutricional del paciente. metadata Martínez Hernández, Eduardo and De La Luz Maya, Rodolfo A. and Ramírez Robledo, María De Los Á and Núñez-Murillo, Gabriela K. and Orozco González, Nelly mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, nelly.orozco@unini.edu.mx (2022) Biodisponibilidad de fósforo en alimentos y su efecto en la enfermedad renal crónica. Población y Salud en Mesoamérica, 19 (2). pp. 293-320.

Article Subjects > Biomedicine Ibero-american International University > Research > Scientific Production Abierto Español The COVID-19 pandemic has put a lot of pressure on health systems worldwide. Mass vaccination against SARS-CoV-2 has reduced morbidity and mortality worldwide. Despite their safety profiles, vaccines, as with any other medical product, can cause adverse events. Yet, in countries with poor epidemiological surveillance and monitoring systems, reporting vaccine-related adverse events is a challenge. The objective of this study was to describe self-reported vaccine adverse events after receiving one of the available COVID-19 vaccine schemes in Ecuador. A cross-sectional analysis based on an online, self-reported, 32-item questionnaire was conducted in Ecuador from 1 April to 15 July 2021. Participants were invited by social media, radio, and TV to voluntarily participate in our study. A total of 6654 participants were included in this study. Furthermore, 38.2% of the participants reported having at least one comorbidity. Patients received AstraZeneca, Pfizer, and Sinovac vaccines, and these were distributed 38.4%, 31.1%, and 30.5%, respectively. Overall, pain or swelling at the injection site 17.2% (n = 4500) and headache 13.3% (n = 3502) were the most reported adverse events. Women addressed events supposedly attributable to vaccination or immunization [ESAVIs] (66.7%), more often than men (33.2%). After receiving the first dose of any available COVID-19 vaccine, a total of 19,501 self-reported ESAVIs were informed (87.0% were mild, 11.5% moderate, and 1.5% severe). In terms of the vaccine type and brand, the most reactogenic vaccine was AstraZeneca with 57.8%, followed by Pfizer (24.9%) and Sinovac (17.3%). After the second dose, 6776 self-reported ESAVIs were reported (87.1% mild, 10.9% moderate, and 2.1% severe). AstraZeneca vaccine users reported a higher proportion of ESAVIs (72.2%) in comparison to Pfizer/BioNTech (15.9%) and Sinovac Vaccine (11.9%). Swelling at the injection site, headache, muscle pain, and fatigue were the most common ESAVIs for the first as well as second doses. In conclusion, most ESAVIs were mild. AstraZeneca users were more likely to report adverse events. Participants without a history of COVID-19 infection, as well as those who received the first dose, were more prone to report ESAVIs metadata Ortiz-Prado, Esteban and Izquierdo-Condoy, Juan S. and Fernandez-Naranjo, Raul and Simbaña-Rivera, Katherine and Vásconez-González, Jorge and Naranjo, Eddy P. Lincango and Cordovez, Simone and Coronel, Barbara and Delgado-Moreira, Karen and Jimbo-Sotomayor, Ruth mail UNSPECIFIED (2022) A Comparative Analysis of a Self-Reported Adverse Events Analysis after Receiving One of the Available SARS-CoV-2 Vaccine Schemes in Ecuador. Vaccines, 10 (7). p. 1047. ISSN 2076-393X

Article Subjects > Biomedicine
Subjects > Nutrition
Ibero-american International University > Research > Scientific Production Abierto Inglés The authors regret the incorrect publication of the actual affiliation for the author José Ramos-Vivas in the original article. The corrected affiliation is provided below: Luis Monzón-Atienzaa, Jimena Bravoa, Álvaro Fernández-Monteroa, Ives Charlie-Silvab, Daniel Monteroa, José Ramos-Vivasa,d,e, Jorge Galindo-Villegasc,*, Félix Acostaa aGrupo de Investigaci'on en Acuicultura (GIA), Instituto Ecoaqua, Universidad de Las Palmas de Gran Canaria, Spain bDepartment of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil cFaculty of Biosciences and Aquaculture, Nord University, Bodø, Norway dResearch Group on Foods, Nutritional Biochemistry and Health, Universidad Europea del Atlántico, 39011 Santander, Spain eDepartment of Project Management, Universidad Internacional Iberoamericana, Campeche 24560, Mexico The authors would like to apologise for any inconvenience caused. metadata Monzón-Atienza, Luis and Bravo, Jimena and Fernández-Montero, Álvaro and Charlie-Silva, Ives and Montero, Daniel and Ramos Vivas, Jose and Galindo-Villegas, Jorge and Acosta, Félix mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, jose.ramos@uneatlantico.es, UNSPECIFIED, UNSPECIFIED (2022) Corrigendum to “Dietary supplementation of Bacillus velezensis improves Vibrio anguillarum clearance in European sea bass by activating essential innate immune mechanisms” [Fish Shellfish Immunol. 124 (2022) 244–253]. Fish & Shellfish Immunology. ISSN 10504648

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Abierto Inglés Antimicrobial-resistant pathogenic bacteria are an increasing problem in public health, especially in the healthcare environment, where nosocomial infection microorganisms find their niche. Among these bacteria, the genus Acinetobacter which belongs to the ESKAPE pathogenic group harbors different multi-drug resistant (MDR) species that cause human nosocomial infections. Although A. baumannii has always attracted more interest, the close-related species A. pittii is the object of more study due to the increase in its isolation and MDR strains. In this work, we present the genomic analysis of five clinically isolated A. pittii strains from a Spanish hospital, with special attention to their genetic resistance determinants and plasmid structures. All the strains harbored different genes related to β-lactam resistance, as well as different MDR efflux pumps. We also found and described, for the first time in this species, point mutations that seem linked with colistin resistance, which highlights the relevance of this comparative analysis among the pathogenic species isolates. metadata Chapartegui-González, Itziar and Lázaro-Díez, María and Ramos Vivas, Jose mail UNSPECIFIED, UNSPECIFIED, jose.ramos@uneatlantico.es (2022) Genetic Resistance Determinants in Clinical Acinetobacter pittii Genomes. Antibiotics, 11 (5). p. 676. ISSN 2079-6382

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Cerrado Inglés Yersiniosis, caused by the fish pathogen Yersinia ruckeri, is a serious bacterial septicaemia affecting mainly salmonids worldwide. The acute infection may result in high mortality without apparent external disease signs, while the chronic one causes moderate to considerable mortality. Survivors of yersiniosis outbreaks become carriers. Y. ruckeri is able to adhere to, and to invade, phagocytic and non-phagocytic fish cells by using unknown molecular mechanisms. The aim of this study was to describe the kinetics of cell invasion by Y. ruckeri serotype O1 biotype 1 in a fish cell line (RTG-2) originating from rainbow trout gonads. The efficiency of invasion by Y. ruckeri was found to be temperature dependent, having a maximum at 20 °C. The bacterium was able to survive up to 96 h postinfection. The incubation of the cells at 4 °C and the pre-incubation of the bacteria with sugars or heat-inactivated antiserum significantly decreased the efficiency of invasion or even completely prevented the invasion of RTG-2 cells. These findings indicate that Y. ruckeri is capable of adhering to, entering and surviving within non-phagocytic cells, and that the intracellular environment may constitute a suitable niche for this pathogen that can favour the spread of infection and/or the maintenance of a carrier state of fish. metadata Padilla, Daniel and Acosta Hernández, Begoña and Ramos Vivas, Jose and Déniz, Soraya and Rosario, Inmaculada and Martín Barrasa, José Luís and Henao, Andrés sánchez and Silva Sergent, Freddy and Ramos Sosa, María josé and García Álvarez, Natalia and Real, Fernando mail UNSPECIFIED, UNSPECIFIED, jose.ramos@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2022) Kinetics of the invasion of a non-phagocytic fish cell line, RTG-2 by Yersinia ruckeri serotype O1 biotype 1. Acta Veterinaria Hungarica. ISSN 0236-6290

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Abierto Inglés Hafnia alvei is receiving increasing attention from both a medical and veterinary point of view, but the diversity of molecules it produces has made the interest in this bacterium extend to the field of probiotics, the microbiota, and above all, to its presence and action on consumer foods. The production of Acyl Homoserine Lactones (AHLs), a type of quorum-sensing (QS) signaling molecule, is the most often-studied chemical signaling molecule in Gram-negative bacteria. H. alvei can use this communication mechanism to promote the expression of certain enzymatic activities in fermented foods, where this bacterium is frequently present. H. alvei also produces a series of molecules involved in the modification of the organoleptic properties of different products, especially cheeses, where it shares space with other microorganisms. Although some strains of this species are implicated in infections in humans, many produce antibacterial compounds, such as bacteriocins, that inhibit the growth of true pathogens, so the characterization of these molecules could be very interesting from the point of view of clinical medicine and the food industry. Lastly, in some cases, H. alvei is responsible for the production of biogenic amines or other compounds of special interest in food health. In this article, we will review the most interesting molecules that produce the H. alvei strains and will discuss some of their properties, both from the point of view of their biological activity on other microorganisms and the properties of different food matrices in which this bacterium usually thrives. metadata Ramos Vivas, Jose and Tapia Martínez, Olga and Elexpuru Zabaleta, Maria and Tutusaus, Kilian and Armas Diaz, Yasmany and Battino, Maurizio and Giampieri, Francesca mail jose.ramos@uneatlantico.es, olga.tapia@uneatlantico.es, maria.elexpuru@uneatlantico.es, kilian.tutusaus@uneatlantico.es, UNSPECIFIED, maurizio.battino@uneatlantico.es, francesca.giampieri@uneatlantico.es (2022) The Molecular Weaponry Produced by the Bacterium Hafnia alvei in Foods. Molecules, 27 (17). p. 5585. ISSN 1420-3049

2021

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Abierto Inglés Acinetobacter baumannii is a Gram-negative coccoid rod species, clinically relevant as a human pathogen, included in the ESKAPE group. Carbapenem-resistant A. baumannii (CRAB) are considered by the World Health Organization (WHO) as a critical priority pathogen for the research and development of new antibiotics. Some of the most relevant features of this pathogen are its intrinsic multidrug resistance and its ability to acquire rapid and effective new resistant determinants against last-resort clinical antibiotics, mostly from other ESKAPE species. The presence of plasmids and mobile genetic elements in their genomes contributes to the acquisition of new antimicrobial resistance determinants. However, although A. baumannii has arisen as an important human pathogen, information about these elements is still not well understood. Current genomic analysis availability has increased our ability to understand the microevolution of bacterial pathogens, including point mutations, genetic dissemination, genomic stability, and pan- and core-genome compositions. In this work, we deeply studied the genomes of four clinical strains from our hospital, and the reference strain ATCC®19606TM, which have shown a remarkable ability to survive and maintain their effective capacity when subjected to long-term stress conditions. With that, our aim was presenting a detailed analysis of their genomes, including antibiotic resistance determinants and plasmid composition. metadata Chapartegui-González, Itziar and Lázaro-Díez, María and Redondo-Salvo, Santiago and Navas, Jesús and Ramos-Vivas, José mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, jose.ramos@uneatlantico.es (2021) Antimicrobial Resistance Determinants in Genomes and Plasmids from Acinetobacter baumannii Clinical Isolates. Antibiotics, 10 (7). p. 753. ISSN 2079-6382

Article Subjects > Biomedicine Ibero-american International University > Research > Scientific Production Abierto Inglés Breast cancer (BC) is one of the most common diseases in the global population. It most commonly presents in women; however, there has been an increase in the number of men diagnosed with the disease, although at a lower rate. Its specific characteristics and associated risk factors mean that preventative measures are considered to be one of the most important methods of avoiding BC. Therefore, education is a fundamental part of this process. The objective of this study is to report on the educational interventions on BC carried out in healthcare between 2016 and 2021. To this end, an integrative review was carried out using the following databases: PubMed (NCBI), Science Direct, Scopus, SciELO and Google Scholar, using the keywords ‘breast cancer’, ‘intervention education’, ‘prevention’ and the Boolean operator ‘AND’. Quantitative, full-text articles in English, Spanish or Portuguese were included. Finally, 19 articles were selected for analysis and it was found that, with regard to educational interventions on BC carried out in healthcare, one article included men and women and the remaining 18 included only women, with interventions carried out in sessions, workshops, in stages and using dynamic techniques. Therefore, there is a pressing need for educational interventions on BC for men and women at all stages of life; however, priority should be given to the young population in order to allow for early prevention. These interventions do not generate costs for the health sector, but they have a positive effect by increasing knowledge and promoting self-care. metadata de Carmen Ortega Jiménez, Mayra and García Rodríguez, Deysi Emilia and Hidalgo Mares, Brenda and Ortega Jiménez, Marcela mail UNSPECIFIED (2021) Educational interventions on breast cancer in men and women: a necessity in primary healthcare. ecancermedicalscience, 15. ISSN 17546605

Article Subjects > Biomedicine
Subjects > Physical Education and Sport
Ibero-american International University > Research > Scientific Production Abierto Español Introducción: La implementación de programas de ejercicio puede mejorar la calidad de vida de pacientes en hemodiálisis (HD). Diversos estudios hablan sobre los beneficios del ejercicio físico en estos pacientes, sin embargo, los efectos sobre marcadores antropométricos, fuerza muscular y tensión arterial (TA) según el tipo de ejercicio no han sido completamente evaluados. El objetivo de esta revisión es analizar estudios cuya intervención consistiera en la implementación de programas de ejercicio en pacientes con HD y proporcionar evidencias de sus efectos sobre los marcadores antropométricos, fuerza muscular y TA. Métodos: Se realizó una búsqueda en la literatura en Medline, LILACS, Scielo y Redalyc, con una temporalidad de 2015 a 2020. Se incluyeron 18 artículos en la presente revisión. Resultados: La combinación de ejercicio anaeróbico y de resistencia aumenta la fuerza muscular, y de igual manera, el ejercicio aeróbico y anaeróbico incrementa la fuerza muscular de las extremidades superiores e inferiores de pacientes en HD. Por otro lado, el ejercicio anaeróbico por sí solo, tiene efectos sobre los marcadores antropométricos, específicamente en el aumento de masa libre de grasa. El ejercicio aeróbico aislado es eficaz para la disminución de la TA. Conclusión: La implementación de programas de ejercicio en pacientes con HD ha demostrado tener efectos positivos sobre la fuerza muscular, los marcadores antropométricos y la TA. metadata Pérez-Jiménez, Ana Karen and Chávez-Becerril, Graciela Berenice and Orozco González, Nelly and Camacho-López, Saby mail UNSPECIFIED, UNSPECIFIED, nelly.orozco@unini.edu.mx, UNSPECIFIED (2021) Efectos del ejercicio físico sobre marcadores antropométricos, fuerza muscular y presión arterial en pacientes con hemodiálisis: una revisión narrativa. Revista de Nutrición Clínica y Metabolismo, 4 (4). pp. 98-115. ISSN 2619564X

Article Subjects > Biomedicine Ibero-american International University > Research > Scientific Production Abierto Inglés Low energy pulsed electromagnetic signals (PEMS) therapy, in the field of bioelectronics, has been suggested as a promising analgesic therapy with special interest in treating conditions with poor response to pharmacotherapy. This study evaluated the effectiveness of PEMS therapy on the treatment of chronic low back pain patients with a neuropathic component. A group of 64 individuals with such condition was allocated to a 2-week treatment period (10 twenty-minute sessions on consecutive days) with an active PEMS therapy device or an inactive device in random order. The pain was assessed on a visual analog scale, and the functional status was assessed using the SF-12 questionnaire. The visual analog scale scores were lower after treatment than at baseline but only in the group treated with the active device. According to the DN4 score, neuropathic pain decreased in both experimental groups with respect to baseline, but this was only significant for the group treated with the active device. Similarly, an improvement in the SF-12 and Medical Outcomes Study (MOS) sleep scale components was reported. The study demonstrated that low-energy PEMS therapy was efficient in reducing pain and improving function in chronic low back pain patients with a neuropathic component. metadata de Teresa, Carlos and Varela-López, Alfonso and Rios-Álvarez, Susana and Gálvez, Rafael and Maire, Coralie and Gracia Villar, Santos and Battino, Maurizio and Quiles, José L. mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, santos.gracia@uneatlantico.es, maurizio.battino@uneatlantico.es, jose.quiles@uneatlantico.es (2021) Evaluation of the Analgesic Efficacy of a Bioelectronic Device in Non-Specific Chronic Low Back Pain with Neuropathic Component. A Randomized Trial. Journal of Clinical Medicine, 10 (8). p. 1781. ISSN 2077-0383

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Abierto Inglés COVID-19 declared as a pandemic that has a faster rate of infection and has impacted the lives and the country’s economy due to forced lockdowns. Its detection using RT-PCR is required long time and due to which its infection has grown exponentially. This creates havoc for the shortage of testing kits in many countries. This work has proposed a new image processing-based technique for the health care systems named “C19D-Net”, to detect “COVID-19” infection from “Chest X-Ray” (XR) images, which can help radiologists to improve their accuracy of detection COVID-19. The proposed system extracts deep learning (DL) features by applying the InceptionV4 architecture and Multiclass SVM classifier to classify and detect COVID-19 infection into four different classes. The dataset of 1900 Chest XR images has been collected from two publicly accessible databases. Images are pre-processed with proper scaling and regular feeding to the proposed model for accuracy attainments. Extensive tests are conducted with the proposed model (“C19D-Net”) and it has succeeded to achieve the highest COVID-19 detection accuracy as 96.24% for 4-classes, 95.51% for three-classes, and 98.1% for two-classes. The proposed method has outperformed well in expressions of “precision”, “accuracy”, “F1-score” and “recall” in comparison with most of the recent previously published methods. As a result, for the present situation of COVID-19, the proposed “C19D-Net” can be employed in places where test kits are in short supply, to help the radiologists to improve their accuracy of detection of COVID-19 patients through XR-Images. metadata Kaur, Prabhjot and Harnal, Shilpi and Tiwari, Rajeev and Alharithi, Fahd S. and Almulihi, Ahmed H. and Delgado Noya, Irene and Goyal, Nitin mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, irene.delgado@uneatlantico.es, UNSPECIFIED (2021) A Hybrid Convolutional Neural Network Model for Diagnosis of COVID-19 Using Chest X-ray Images. International Journal of Environmental Research and Public Health, 18 (22). p. 12191. ISSN 1660-4601

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Abierto Inglés Cancer stem cells (CSCs) are a rare tumor subpopulation with high differentiation, proliferative and tumorigenic potential compared to the remaining tumor population. CSCs were first discovered by Bonnet and Dick in 1997 in acute myeloid leukemia. The identification and isolation of these cells in this pioneering study were carried out through the flow cytometry, exploiting the presence of specific cell surface molecular markers (CD34+/CD38−). In the following years, different strategies and projects have been developed for the study of CSCs, which are basically divided into surface markers assays and functional assays; some of these techniques also allow working with a cellular model that better mimics the tumor architecture. The purpose of this mini review is to summarize and briefly describe all the current methods used for the identification, isolation and enrichment of CSCs, describing, where possible, the molecular basis, the advantages and disadvantages of each technique with a particular focus on those that offer a three-dimensional culture. metadata Cianciosi, Danila and Ansary, Johura and Forbes-Hernandez, Tamara Y. and Regolo, Lucia and Quinzi, Denise and Gracia Villar, Santos and Garcia Villena, Eduardo and Tutusaus Pifarre, Kilian and Alvarez-Suarez, José M. and Battino, Maurizio and Giampieri, Francesca mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, santos.gracia@uneatlantico.es, eduardo.garcia@uneatlantico.es, kilian.tutusaus@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2021) The Molecular Basis of Different Approaches for the Study of Cancer Stem Cells and the Advantages and Disadvantages of a Three-Dimensional Culture. Molecules, 26 (9). p. 2615. ISSN 1420-3049

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Abierto Inglés Age-related bone disorders such as osteoporosis or osteoarthritis are a major public health problem due to the functional disability for millions of people worldwide. Furthermore, fractures are associated with a higher degree of morbidity and mortality in the long term, which generates greater financial and health costs. As the world population becomes older, the incidence of this type of disease increases and this effect seems notably greater in those countries that present a more westernized lifestyle. Thus, increased efforts are directed toward reducing risks that need to focus not only on the prevention of bone diseases, but also on the treatment of persons already afflicted. Evidence is accumulating that dietary lipids play an important role in bone health which results relevant to develop effective interventions for prevent bone diseases or alterations, especially in the elderly segment of the population. This review focuses on evidence about the effects of dietary lipids on bone health and describes possible mechanisms to explain how lipids act on bone metabolism during aging. Little work, however, has been accomplished in humans, so this is a challenge for future research. metadata Romero-Márquez, Jose M. and Varela-López, Alfonso and Navarro-Hortal, María D. and Badillo-Carrasco, Alberto and Forbes-Hernández, Tamara Y. and Giampieri, Francesca and Dominguez Azpíroz, Irma and Madrigal-Hoyos, Lorena and Battino, Maurizio and Quiles, José L. mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, irma.dominguez@uneatlantico.es, lorena.madrigal@uneatlantico.es, maurizio.battino@uneatlantico.es, jose.quiles@uneatlantico.es (2021) Molecular Interactions between Dietary Lipids and Bone Tissue during Aging. International Journal of Molecular Sciences, 22 (12). p. 6473. ISSN 1422-0067

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Abierto Inglés Therapeutic bacteriophages, commonly called as phages, are a promising potential alternative to antibiotics in the management of bacterial infections of a wide range of organisms including cultured fish. Their natural immunogenicity often induces the modulation of a variated collection of immune responses within several types of immunocytes while promoting specific mechanisms of bacterial clearance. However, to achieve standardized treatments at the practical level and avoid possible side effects in cultivated fish, several improvements in the understanding of their biology and the associated genomes are required. Interestingly, a particular feature with therapeutic potential among all phages is the production of lytic enzymes. The use of such enzymes against human and livestock pathogens has already provided in vitro and in vivo promissory results. So far, the best-understood phages utilized to fight against either Gram-negative or Gram-positive bacterial species in fish culture are mainly restricted to the Myoviridae and Podoviridae, and the Siphoviridae, respectively. However, the current functional use of phages against bacterial pathogens of cultured fish is still in its infancy. Based on the available data, in this review, we summarize the current knowledge about phage, identify gaps, and provide insights into the possible bacterial control strategies they might represent for managing aquaculture-related bacterial diseases. metadata Ramos-Vivas, José and Superio, Joshua and Galindo-Villegas, Jorge and Acosta, Félix mail jose.ramos@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2021) Phage Therapy as a Focused Management Strategy in Aquaculture. International Journal of Molecular Sciences, 22 (19). p. 10436. ISSN 1422-0067

Article Subjects > Biomedicine
Subjects > Nutrition
Ibero-american International University > Research > Scientific Production Abierto Inglés Protein-energy wasting (PEW) and poor health-related quality of life (HRQoL) are independently associated with morbi-mortality in continuous ambulatory peritoneal dialysis (CAPD). PEW may reduce HRQoL; however, we hypothesized HRQoL is affected differentially by PEW degrees or by individual criteria of nutritional status. Aim To evaluate HRQoL according to PEW severity and nutritional status indicators in CAPD. This is a cross-sectional study in 151 patients. Subjective global assessment (SGA) was employed, and nutritional status classified as normal, mild-moderate PEW, and severe PEW. HRQoL was evaluated using Kidney Disease Quality of Life Short Form™, including physical (PCS), mental (MCS) and kidney disease (KDCS) components, and their subscales. Dietary intake, anthropometric and biochemical variables were measured. Forty-six percent of patients were well-nourished, 44% had mild-moderate PEW, and 10% severe PEW. Compared with well-nourished patients, those with mild-moderate (p = 0.06) and severe (p = 0.005) PEW had lower HRQoL score [68 (52–75), 55 (45–72), 46 (43–58), respectively]. PCS, MCS, and KDCS and their subscales had lower values as PEW was more severe. Patients with obesity and hypoalbuminemia had significantly lower HRQoL overall and component scores than their counterparts. Dietary intake was not associated with quality of life. In multivariate analysis obesity, PEW (by SGA), hypoalbuminemia, and low educational level predicted poor HRQoL (χ2 58.2, p < 0.0001). As conclusion, PEW severity was related with worse HRQoL, either as overall score or in every component or subscale in CAPD patients. Poor HRQoL was predicted independently by PEW severity and obesity; additional predictors were hypoalbuminemia and low education. metadata Orozco González, Nelly and Márquez-Herrera, Roxana M. and Cortés-Sanabria, Laura and Cueto-Manzano, Alfonso M. and Gutiérrez-Medina, Margarita and Gómez-García, Erika F. and Rojas-Campos, Enrique and Paniagua-Sierra, José R. and Martín del Campo, Fabiola mail nelly.orozco@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2021) Severity of protein-energy wasting and obesity are independently related with poor quality of life in peritoneal dialysis patients. Nefrología. ISSN 02116995

2020

Article Subjects > Biomedicine
Subjects > Nutrition
Ibero-american International University > Research > Scientific Production Cerrado Inglés Objective: The aim of this study was to validate a direct taste perception test (TPT) and evaluate its performance in patients on dialysis. Methods: This cross-sectional study was carried out in a tertiary-care hospital. A TPT was validated on 112 healthy subjects and applied on 43 patients on hemodialysis and 32 patients on peritoneal dialysis. All participants were presented a 10-mL sample to identify and rate intensity of primary tastes: sweet (sucrose 2%), sour (citric acid 0.1%), bitter (caffeine 0.06%), salty (sodium chloride 0.5%), and umami (sodium glutamate 0.25%). The internal consistency and repeatability of TPT was assessed by Cronbach's alpha and intraclass correlation coefficient. Chi-square and Mann-Whitney U tests were used to compare groups. Results: TPT had Cronbach's alpha of 0.77. Intraclass correlation coefficient was 0.74 for sweet, P < .0001; 0.57 for salty, P = .001; 0.62 for sour, P < .0001; 0.78 for bitter, P < .0001; and 0.76 for umami, P < .0001. Compared with controls, patients on peritoneal dialysis were less able to identify sweet and umami tastes (P < .05) and marginally (P = .06) sour taste, whereas patients on hemodialysis were marginally (P = .06) less able to identify sweet and salty tastes. Bitter was not differently identified between groups. According to the visual analog scale (0-10), all patients on dialysis perceived sour taste less intensely than control subjects (P < .05). Conclusions: This TPT for patients on dialysis had adequate reliability to identify five primary tastes in a clinical setting. Except for bitter taste, perception of all the primary tastes was altered in patients on dialysis compared with control subjects. A broader use of this test would help identify taste alterations and implement strategies for malnutrition. metadata Márquez-Herrera, Roxana M. and Núñez-Murillo, Gabriela K. and Ruíz-Gurrola, Claudia G. and Gómez-García, Erika F. and Orozco-González, Claudia N. and Cortes-Sanabria, Laura and Cueto-Manzano, Alfonso M. and Rojas-Campos, Enrique mail UNSPECIFIED (2020) Clinical Taste Perception Test for Patients With End-Stage Kidney Disease on Dialysis. Journal of Renal Nutrition, 30 (1). pp. 79-84. ISSN 10512276

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production
Cerrado Inglés Fasting, caloric restriction and foods or compounds mimicking the biological effects of caloric restriction, known as caloric restriction mimetics, have been associated with a lower risk of age-related diseases, including cardiovascular diseases, cancer and cognitive decline, and a longer lifespan. Reduced calorie intake has been shown to stimulate cancer immunosurveillance, reducing the migration of immunosuppressive regulatory T cells towards the tumor bulk. Autophagy stimulation via reduction of lysine acetylation, increased sensitivity to chemo- and immunotherapy, along with a reduction of insulin-like growth factor 1 and reactive oxygen species have been described as some of the major effects triggered by caloric restriction. Fasting and caloric restriction have also been shown to beneficially influence gut microbiota composition, modify host metabolism, reduce total cholesterol and triglyceride levels, lower diastolic blood pressure and elevate morning cortisol level, with beneficial modulatory effects on cardiopulmonary fitness, body fat and weight, fatigue and weakness, and general quality of life. Moreover, caloric restriction may reduce the carcinogenic and metastatic potential of cancer stem cells, which are generally considered responsible of tumor formation and relapse. Here, we reviewed in vitro and in vivo studies describing the effects of fasting, caloric restriction and some caloric restriction mimetics on immunosurveillance, gut microbiota, metabolism, and cancer stem cell growth, highlighting the molecular and cellular mechanisms underlying these effects. Additionally, studies on caloric restriction interventions in cancer patients or cancer risk subjects are discussed. Considering the promising effects associated with caloric restriction and caloric restriction mimetics, we think that controlled-randomized large clinical trials are warranted to evaluate the inclusion of these non-pharmacological approaches in clinical practice. metadata Pistollato, Francesca and Forbes-Hernández, Tamara Y. and Calderón Iglesias, Rubén and Ruiz Salces, Roberto and Elexpuru Zabaleta, Maria and Dominguez Azpíroz, Irma and Cianciosi, Danila and Quiles, José L. and Giampieri, Francesca and Battino, Maurizio mail francesca.pistollato@uneatlantico.es, UNSPECIFIED, ruben.calderon@uneatlantico.es, roberto.ruiz@uneatlantico.es, maria.elexpuru@uneatlantico.es, irma.dominguez@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2020) Effects of caloric restriction on immunosurveillance, microbiota and cancer cell phenotype: Possible implications for cancer treatment. Seminars in Cancer Biology. ISSN 1044-579X

Article Subjects > Biomedicine Ibero-american International University > Research > Scientific Production Abierto Español Objetivo: Determinar factores de riesgo para Evento cerebrovascular en jóvenes menores de 45 años en el Valle de Toluca. Metodología: Estudio transversal y correlacional. Se aplico un cuestionario para determinar los factores de riesgo para evento cerebrovascular en los adultos jóvenes. Se compararon dos grupos etarios de 18 a 32 y 33 a 45 años, mediante una U de Mann Whitney. Posteriormente se hizo un correlación de Pearson y se calculó las Odds ratio y el riesgo relativo (p < 0.05) Contribución: Se analizó 2593 encuestas, el 62% pertenece al grupo de 18 a 32 años. 68.9% presentan algún factor de riesgo bajo-medio para evento cerebrovascular. El 20% hace ejercicio más de 2:30 h. y solo el 3.4% tiene una dieta adecuada. La presencia de los factores de riesgo está relacionada con el grupo etario, en los de 33 a 45 años, las comorbilidades (sobrepeso/obesidad, hipertensión y diabetes). Mientras que el estilo de vida (tabaquismo, alcoholismo y el uso de drogas), en los menores de 32 años. Esto indica que los programas de sensibilización y capacitación deberían de dirigirse de manera diferente, de acuerdo con el grupo etario. metadata Rivera-Ramírez, Fabiola and Duarte-Troche, María del Carmen and Tenorio-Borroto, Esvieta and Orozco González, Nelly mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, nelly.orozco@unini.edu.mx (2020) Factores de riesgo para accidente cerebrovascular en adultos jóvenes. Revista de Ciencias de la Salud. pp. 1-11. ISSN 2410-3551

2019

Thesis Subjects > Biomedicine
Subjects > Physical Education and Sport
Subjects > Nutrition
Ibero-american International University > Research > Doctoral Thesis Cerrado Español Actualmente la obesidad infantil es considerada como la pandemia del siglo XXI, con una alta prevalencia mundial, aumentando de 32 millones en 1990 a 41 millones en el año 2016. Es de origen multifactorial con intervención de factores genéticos, ambientales y conductuales. Está asociada a una amplia gama de complicaciones multiorgánicas graves y a un creciente riesgo de desarrollar tempranamente enfermedades crónicas no transmisibles como la diabetes mellitus y enfermedades cardiovasculares que son la principal causa de mortalidad y discapacidad en la adultez. Según la OMS, si continúa esta alta prevalencia, se estima que habrá 70 millones de niños con obesidad infantil para el año 2025. Las estrategias más efectivas de prevención son las que asocian varios componentes y para que sean más eficaces deben incorporar a la familia e iniciarse precozmente. El objetivo de esta investigación fue diseñar un Plan Estratégico de Prevención de Sobrepeso y Obesidad infantil en el Hospital General del Instituto Ecuatoriano de Seguridad Social (IESS) Quevedo, el cual, permitió brindar un tratamiento oportuno con la finalidad de prevenir las complicaciones a corto, mediano y largo plazo. Se evaluó la efectividad del Plan Estratégico mediante la validación del cuestionario con el programa informático Statistical Package for the Social Sciences (SPSS), corroborando el efecto que las intervenciones educativas tuvieron en la modificación o adquisición de hábitos alimentarios y actividad física. Se obtuvieron importantes resultados: las charlas del Club de Nutrición Infantil tuvieron una gran acogida entre los afiliados, los temas impartidos permitieron aclarar conceptos acerca de una nutrición saludable, y conocer cómo mejorar su estilo de vida. Además, se concientizó a los afiliados acerca de la importancia de disminuir el consumo de sal, azúcares refinadas y grasas saturadas, y aumentar el consumo de agua, frutas, verduras y legumbres que se pudo comprobar posterior a la intervención educativa. metadata Díaz Olmedo, Cecilia Maribel mail cm.diaz@hotmail.es (2019) Diseño de un plan estratégico para la prevención de sobrepeso y obesidad infantil en Quevedo-Ecuador. Doctoral thesis, Universidad Internacional Iberoamericana México.

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Cerrado Inglés About 1 of 10 women, particularly those older than 60 years of age, shows some degree of thyroid hormone deficiency. Thyroid diseases are generally characterized by perturbations of thyroid signaling homeostasis. The most common examples of thyroid diseases include hypothyroidism, hyperthyroidism, and several types of thyroid cancers. Phytochemicals have been shown to have either beneficial or detrimental effects on thyroid function. Some flavonoids have been reported to affect the expression and the activity of several thyroid-related enzymes and proteins, and for this reason some concerns have been raised about the possible thyroid-disruptive properties of foods enriched in these substances. On the other hand, the beneficial effects of some plant-derived compounds, such as myricetin, quercetin, apigenin, rutin, genistein, and curcumin, and their possible role as adjuvants for the treatment of thyroid cancers have been described. Here, the role of phytochemicals in thyroid signaling modulation and their possible beneficial or detrimental effects on thyroid disease risk are discussed. metadata Pistollato, Francesca and Masías Vergara, Manuel and Agudo-Toyos, Pablo and Giampieri, Francesca and Battino, Maurizio mail francesca.pistollato@uneatlantico.es, manuel.masias@uneatlantico.es, pablo.agudo@uenatlantico.es, UNSPECIFIED, UNSPECIFIED (2019) Effects of phytochemicals on thyroid function and their possible role in thyroid disease. Annals of the New York Academy of Sciences, 1443 (1). pp. 3-19. ISSN 0077-8923

Article Subjects > Biomedicine Ibero-american International University > Research > Scientific Production Abierto Español Objetivo: determinar la asociación entre el apego a la dieta y la educación nutricional en los pacientes con tratamiento de diálisis. Materiales y métodos: estudio transversal en pacientes con enfermedad renal crónica (ERC) en tratamiento de diálisis ≥6 meses, que han recibido educación nutricional previamente. Se evaluó el estado de nutrición mediante la Valoración Global Subjetiva (VGS), toma de pliegues cutáneos (tricipital y subescapular), peso seco y estatura (de acuerdo con los parámetros establecidos por la International Society for Advances of Kinanthropometry); los conocimientos nutricionales y su adherencia mediante la Encuesta de Conocimientos y Adherencia al Régimen Terapéutico, y la calidad de vida mediante el instrumento KDQOL-SF™. Resultados: se incluyeron 85 pacientes, 46 (54%) hombres y 39 (46%) mujeres con una edad media de 42 ±17 años y un tiempo medio en diálisis de 3 ± 1.96 años. El 58% de los pacientes no presentó apego al régimen dietético. Sin embargo, el 89% de los pacientes se apegaron a la recomendación de la restricción de sodio, mientras que el 59% se adhirió al consumo de líquidos. De acuerdo con la VGS, el 58% de los pacientes presentaron desnutrición leve/moderada; no obstante, el 71% tuvieron grasa promedio según la sumatoria de pliegues y el 67% presentó un estado de nutrición normal determinado por el de Índice de Masa Corporal (IMC). Conclusión: no se observó diferencia significativa en la adherencia al tratamiento dietético en aquellos pacientes que tienen conocimientos nutricionales respecto a los que no los tienen. metadata Orozco González, Nelly and Pérez-Jiménez, Ana Karen and Chávez-Becerril, Graciela Berenice mail nelly.orozco@unini.edu.mx, UNSPECIFIED, UNSPECIFIED (2019) Relación entre el apego a la dieta y la educación nutricional en pacientes con diálisis del Hospital General de Atlacomulco y el Hospital General de San Felipe del Progreso, Estado de México. Población y Salud en Mesoamérica. ISSN 1659-0201

2018

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Cerrado Inglés During the process of beeswax recycling, many industrial derivatives are obtained. These matrices may have an interesting healthy and commercial potential but to date they have not been properly studied. The aim of the present work was to evaluate the proximal and phytochemical composition, the antioxidant capacity and cytotoxic effects of two by-products from beeswax recycling process named MUD 1 and MUD 2 on liver hepatocellular carcinoma. Our results showed that MUD 1 presented the highest (P < .05) fiber, protein, carbohydrate, polyphenol and flavonoid concentration, as well as the highest (P < .05) total antioxidant capacity than the MUD 2 samples. MUD1 exerted also anticancer activity on HepG2 cells, by reducing cellular viability, increasing intracellular ROS levels and affecting mitochondrial functionality in a dose-dependent manner. We showed for the first time that by-products from beeswax recycling process can represent a rich source of phytochemicals with high total antioxidant capacity and anticancer activity; however, further researches are necessary to evaluate their potentiality for human health by in vivo studies. metadata Giampieri, Francesca and Quiles, José L. and Orantes-Bermejo, Francisco J. and Gasparrini, Massimiliano and Forbes-Hernandez, Tamara Y. and Sánchez-González, Cristina and Llopis, Juan and Rivas-García, Lorenzo and Afrin, Sadia and Varela-López, Alfonso and Cianciosi, Danila and Reboredo-Rodriguez, Patricia and Fernández-Piñar, Cristina Torres and Caderón Iglesia, Rubén and Ruiz Salces, Roberto and Aparicio Obregón, Silvia and Crespo-Álvarez, Jorge and Dzul Lopez, Luis and Xiao, Jianbo and Battino, Maurizio mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, ruben.calderon@uneatlantico.es, roberto.ruiz@uneatlantico.es, silvia.aparicio@uneatlantico.es, jorge.crespo@uneatlantico.es, luis.dzul@unini.edu.mx, UNSPECIFIED, maurizio.battino@uneatlantico.es (2018) Are by-products from beeswax recycling process a new promising source of bioactive compounds with biomedical properties? Food and Chemical Toxicology, 112. pp. 126-133. ISSN 0278-6915

Article Subjects > Biomedicine
Subjects > Nutrition
Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Cerrado Inglés Ample epidemiological evidence suggests a strong correlation among diet, lifestyle factors and the onset and consolidation of dementia and Alzheimer’s disease (AD). It has been demonstrated that AD, diabetes, obesity, insulin resistance, and cardiovascular disease are strongly interconnected pathologies. Preventive strategies and nutritional interventions seem to be promising approaches to delay neurocognitive decline and reduce the risk of AD and other non-psychiatric co-morbidities. In this regard, healthy dietary patterns, characterized by high intake of plant-based foods, probiotics, antioxidants, soy beans, nuts, and omega-3 polyunsaturated fatty acids, and a low intake of saturated fats, animal-derived proteins, and refined sugars, have been shown to decrease the risk of neurocognitive impairments and eventually the onset of AD. Here we review the role of some nutrients and, in particular, of healthy dietary patterns, such as the Mediterranean diet and other emerging healthy diets, DASH (Dietary Approach to Stop Hypertension) and MIND (Mediterranean-DASH dietIntervention for Neurodegenerative Delay), for the maintenance of cognitive performance, focusing specifically on human studies. The beneficial effects associated with overall diet composition, rather than single nutrient supplementations, for the prevention or the delay of AD and dementia are discussed. metadata Pistollato, Francesca and Calderón Iglesias, Rubén and Ruiz Salces, Roberto and Aparicio-Obregón, Silvia and Crespo-Álvarez, Jorge and Dzul Lopez, Luis Alonso and Manna, Piera Pia and Giampieri, Francesca and Battino, Maurizio mail francesca.pistollato@uneatlantico.es, ruben.calderon@uneatlantico.es, roberto.ruiz@uneatlantico.es, silvia.aparicio@uneatlantico.es, jorge.crespo@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2018) Nutritional patterns associated with the maintenance of neurocognitive functions and the risk of dementia and Alzheimer’s disease: A focus on human studies. Pharmacological Research, 131. pp. 32-43. ISSN 10436618

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Cerrado Inglés A protracted pro-inflammatory state is the common denominator in the development, progression and complication of the common chronic diseases. Dietary antioxidants represent an efficient tool to counteract this inflammatory state. The aim of the present work was to evaluate the effects of strawberry extracts on inflammation evoked by E. Coli lipopolysaccharide in Human Dermal Fibroblast, by measuring reactive oxygen species production, apoptosis rate, antioxidant enzymes activity, mitochondria functionality and also investigating the molecular pathway involved in inflammatory and antioxidant response. The results demonstrated that strawberry pre-treatment reduced intracellular reactive oxygen species levels, apoptotic rate, improved antioxidant defences and mitochondria functionality in lipopolysaccharide -treated cells. Strawberry exerted these protective activities through the inhibition of the NF-kB signalling pathway and the stimulation of the Nrf2 pathway, with a mechanism AMPK-dependent. These results confirm the health benefits of strawberry in the prevention of inflammation and oxidative stress condition in lipopolysaccharide-treated cells. metadata Gasparrini, Massimiliano and Giampieri, Francesca and Forbes-Hernandez, Tamara Y. and Afrin, Sadia and Cianciosi, Danila and Reboredo-Rodriguez, Patricia and Varela-Lopez, Alfonso and Zhang, JiaoJiao and Quiles, Josè L. and Mezzetti, Bruno and Bompadre, Stefano and Battino, Maurizio mail UNSPECIFIED, UNSPECIFIED, tamara.forbes@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2018) Strawberry extracts efficiently counteract inflammatory stress induced by the endotoxin lipopolysaccharide in Human Dermal Fibroblast. Food and Chemical Toxicology, 114. pp. 128-140. ISSN 0278-6915

2017

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Cerrado Inglés A common denominator in the pathogenesis of most chronic inflammatory diseases is the involvement of oxidative stress, related to ROS production by all aerobic organisms. Dietary antioxidants from plant foods represent an efficient strategy to counteract this condition. The aim of the present study was to evaluate the protective effects of strawberry extracts on inflammatory status induced by E. Coli LPS on RAW 264.7 macrophages by measuring the main oxidative and inflammatory biomarkers and investigating the molecular pathways involved. Strawberry pre-treatment efficiently counteracted LPS-induced oxidative stress reducing the amount of ROS and nitrite production, stimulating endogenous antioxidant enzyme activities and enhancing protection against lipid, protein and DNA damage (P < 0.05). Strawberry pre-treatment exerted these protective effects primarily through the activation of the Nrf2 pathway, which is markedly AMPK-dependent and also by the modulation of the NF-kB signalling pathway. Finally, an improvement in mitochondria functionality was also detected. The results obtained in this work highlight the health benefit of strawberries against inflammatory and oxidative stress in LPS-stimulated RAW 264.7 macrophages, investigating for the first time the possible involved molecular mechanisms. metadata Gasparrini, Massimiliano and Forbes-Hernandez, Tamara Y. and Giampieri, Francesca and Afrin, Sadia and Alvarez-Suarez, Josè M. and Mazzoni, Luca and Mezzetti, Bruno and Quiles, Josè L. and Battino, Maurizio mail UNSPECIFIED, tamara.forbes@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2017) Anti-inflammatory effect of strawberry extract against LPS-induced stress in RAW 264.7 macrophages. Food and Chemical Toxicology, 102. pp. 1-10. ISSN 0278-6915

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Abierto Inglés Regulation of lipid metabolism is essential for treatment and prevention of several chronic diseases such as obesity, diabetes, and cardiovascular diseases, which are responsible for most deaths worldwide. It has been demonstrated that the AMP-activated protein kinase (AMPK) has a direct impact on lipid metabolism by modulating several downstream-signaling components. The main objective of the present work was to evaluate the in vitro effect of a methanolic strawberry extract on AMPK and its possible repercussion on lipid metabolism in human hepatocellular carcinoma cells (HepG2). For such purpose, the lipid profile and the expression of proteins metabolically related to AMPK were determined on cells lysates. The results demonstrated that strawberry methanolic extract decreased total cholesterol, low-density lipoprotein (LDL)-cholesterol, and triglycerides levels (up to 0.50-, 0.30-, and 0.40-fold, respectively) while it stimulated the p-AMPK/AMPK expression (up to 3.06-fold), compared to the control. AMPK stimulation led to the phosphorylation and consequent inactivation of acetyl coenzyme A carboxylase (ACC) and inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the major regulators of fatty acids and cholesterol synthesis, respectively. Strawberry treatment also entailed a 4.34-, 2.37-, and 2.47-fold overexpression of LDL receptor, sirtuin 1 (Sirt1), and the peroxisome proliferator activated receptor gamma coactivator 1-alpha (PGC-1α), respectively, compared to control. The observed results were counteracted by treatment with compound C, an AMPK pharmacological inhibitor, confirming that multiple effects of strawberries on lipid metabolism are mediated by the activation of this protein. metadata Forbes-Hernandez, Tamara Y. and Giampieri, Francesca and Gasparrini, Massimiliano and Afrin, Sadia and Mazzoni, Luca and Cordero, Mario and Mezzetti, Bruno and Quiles, José L. and Battino, Maurizio mail tamara.forbes@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2017) Lipid Accumulation in HepG2 Cells Is Attenuated by Strawberry Extract through AMPK Activation. Nutrients, 9 (6). p. 621. ISSN 2072-6643

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Abierto Inglés A protracted pro-inflammatory state is a major contributing factor in the development, progression and complication of the most common chronic pathologies. Fruit and vegetables represent the main sources of dietary antioxidants and their consumption can be considered an efficient tool to counteract inflammatory states. In this context an evaluation of the protective effects of strawberry extracts on inflammatory stress induced by E. coli LPS on human dermal fibroblast cells was performed in terms of viability assays, ROS and nitrite production and biomarkers of oxidative damage of the main biological macromolecules. The results demonstrated that strawberry extracts exerted an anti-inflammatory effect on LPS-treated cells, through an increase in cell viability, and the reduction of ROS and nitrite levels, and lipid, protein and DNA damage. This work showed for the first time the potential health benefits of strawberry extract against inflammatory and oxidative stress in LPS-treated human dermal fibroblast cells. metadata Gasparrini, Massimiliano and Forbes-Hernandez, Tamara Y. and Giampieri, Francesca and Afrin, Sadia and Mezzetti, Bruno and Quiles, José L. and Bompadre, Stefano and Battino, Maurizio mail UNSPECIFIED, tamara.forbes@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2017) Protective Effect of Strawberry Extract against Inflammatory Stress Induced in Human Dermal Fibroblasts. Molecules, 22 (1). p. 164. ISSN 1420-3049

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Abierto Inglés Dyslipidemia and oxidation of low density lipoproteins (LDL) are recognized as critical factors in the development of atherosclerosis. Healthy dietary patterns, with abundant fruit and vegetable consumption, may prevent the onset of these risk factors due to the presence of phytochemical compounds. Strawberries are known for their high content of polyphenols; among them, flavonoids are the major constituents, and it is presumed that they are responsible for the biological activity of the fruit. Nevertheless, there are only a few studies that actually evaluate the effects of different fractions isolated from strawberries. In order to assess the effects of two different strawberry extracts (whole methanolic extract/anthocyanin-enriched fraction) on the lipid profile and antioxidant status in human hepatocellular carcinoma (HepG2) cells, the triglycerides and LDL-cholesterol content, lipid peroxidation, intracellular reactive oxygen species (ROS) content and antioxidant enzymes’ activity on cell lysates were determined. Results demonstrated that both strawberry extracts not only improved the lipid metabolism by decreasing triglycerides and LDL-cholesterol contents, but also improved the redox state of HepG2 cells by modulating thiobarbituric acid-reactive substances production, antioxidant enzyme activity and ROS generation. The observed effects were more pronounced for the anthocyanin-enriched fraction. metadata Forbes-Hernandez, Tamara Y. and Gasparrini, Massimiliano and Afrin, Sadia and Cianciosi, Danila and González-Paramás, Ana and Santos-Buelga, Celestino and Mezzetti, Bruno and Quiles, José L. and Battino, Maurizio and Giampieri, Francesca and Bompadre, Stefano mail tamara.forbes@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es, UNSPECIFIED, UNSPECIFIED (2017) Strawberry (cv. Romina) Methanolic Extract and Anthocyanin-Enriched Fraction Improve Lipid Profile and Antioxidant Status in HepG2 Cells. International Journal of Molecular Sciences, 18 (6). p. 1149. ISSN 1422-0067

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Abierto Inglés Extreme exposure of skin to Ultraviolet A (UVA)-radiation may induce a dysregulated production of reactive oxygen species (ROS) which can interact with cellular biomolecules leading to oxidative stress, inflammation, DNA damage, and alteration of cellular molecular pathways, responsible for skin photoaging, hyperplasia, erythema, and cancer. For these reasons, the use of dietary natural bioactive compounds with remarkable antioxidant activity could be a strategic tool to counteract these UVA-radiation-caused deleterious effects. Thus, the purpose of the present work was to test the efficacy of strawberry (50 μg/mL)-based formulations supplemented with Coenzyme Q10 (100 μg/mL) and sun protection factor 10 in human dermal fibroblasts irradiated with UVA-radiation. The apoptosis rate, the amount of intracellular reactive oxygen species (ROS) production, the expression of proteins involved in antioxidant and inflammatory response, and mitochondrial functionality were evaluated. The results showed that the synergic topical use of strawberry and Coenzyme Q10 provided a significant (p < 0.05) photoprotective effect, reducing cell death and ROS, increasing antioxidant defense, lowering inflammatory markers, and improving mitochondrial functionality. The obtained results suggest the use of strawberry-based formulations as an innovative, natural, and useful tool for the prevention of UVA exposure-induced skin diseases in order to decrease or substitute the amount of synthetic sunscreen agents. metadata Gasparrini, Massimiliano and Forbes-Hernandez, Tamara Y. and Afrin, Sadia and Reboredo-Rodriguez, Patricia and Cianciosi, Danila and Mezzetti, Bruno and Quiles, José L. and Bompadre, Stefano and Battino, Maurizio and Giampieri, Francesca mail UNSPECIFIED, tamara.forbes@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es, UNSPECIFIED (2017) Strawberry-Based Cosmetic Formulations Protect Human Dermal Fibroblasts against UVA-Induced Damage. Nutrients, 9 (6). p. 605. ISSN 2072-6643

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Cerrado Inglés It is generally accepted that a fruit and vegetable–enriched diet is favorable for human health. The consumption of strawberries, in particular, has been related to the maintenance of well-being and the prevention of several chronic diseases, owing to the high contents of antioxidants and phytochemicals present in the fruit. Several biological effects have been explained through the total antioxidant capacity exerted by these bioactive compounds, but recently more intricate mechanisms have begun to be examined. In this context, it has been reported that strawberry phenolics are able to exert anti-inflammatory, anticarcinogenic, antiproliferative, and antiatherosclerotic activities, acting on specific molecular pathways related to antioxidant defenses, metabolism, survival, and proliferation. The overall aim of this work is to discuss and update the cellular and molecular mechanisms recently proposed to clarify the effects of strawberry phenolics on human health, with particular attention to the most common chronic diseases, such as metabolic syndrome, cardiovascular disease, and cancer. metadata Giampieri, Francesca and Forbes-Hernandez, Tamara Y. and Gasparrini, Massimiliano and Afrin, Sadia and Cianciosi, Danila and Reboredo-Rodriguez, Patricia and Varela-Lopez, Alfonso and Quiles, Jose L. and Mezzetti, Bruno and Battino, Maurizio mail UNSPECIFIED, tamara.forbes@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2017) The healthy effects of strawberry bioactive compounds on molecular pathways related to chronic diseases. Annals of the New York Academy of Sciences, 1398 (1). pp. 62-71. ISSN 0077-8923

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Cerrado Inglés Among gynaecological cancers, ovarian cancer represents the leading cause of death in women. Current treatment for ovarian cancer entails surgery followed by combined chemotherapy with platinum and taxane, which are associated, particularly cisplatin, with severe side effects. While this treatment approach appears to be initially effective in a high number of patients, nearly 70% of them suffer a relapse within a few months after initial treatment. Therefore, more effective and better-tolerated treatment options are clearly needed. In recent years, several natural compounds (such as curcumin, epigallocatechin 3-gallate (EGCG), resveratrol, sulforaphane and Withaferin-A), characterized by long-term safety and negligible and/or inexistent side effects, have been proposed as possible adjuvants of traditional chemotherapy. Indeed, several in vitro and in vivo studies have shown that phytocompounds can effectively inhibit tumor cell proliferation, stimulate autophagy, induce apoptosis, and specifically target ovarian cancer stem cells (CSCs), which are generally considered to be responsible for tumor recurrence in several types of cancer. Here we review current literature on the role of natural products in ovarian cancer chemoprevention, highlighting their effects particularly on the regulation of inflammation, autophagy, proliferation and apoptosis, chemotherapy resistance, and ovarian CSC growth. metadata Pistollato, Francesca and Calderón Iglesias, Rubén and Ruiz Salces, Roberto and Aparicio Obregón, Silvia and Crespo Alvare, Jorge and Dzul Lopez, Luis and Giampieri, Francesca and Battino, Maurizio mail UNSPECIFIED, ruben.calderon@uneatlantico.es, roberto.ruiz@uneatlantico.es, silvia.aparicio@uneatlantico.es, jorge.crespo@uneatlantico.es, luis.dzul@unini.edu.mx, UNSPECIFIED, maurizio.battino@uneatlantico.es (2017) The use of natural compounds for the targeting and chemoprevention of ovarian cancer. Cancer Letters, 411. pp. 191-200. ISSN 0304-3835

2016

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Cerrado Inglés Doxorubicin (Dox), one of the most used chemotherapeutic agents, is known to generate oxidative stress and block DNA synthesis, which result in severe dose-limiting toxicity. A strategy to protect against Dox toxic effects could be to use dietary antioxidants of which fruits and vegetable are a rich source. In this context, strawberry consumption is associated with the maintenance of good health and the prevention of several diseases, thanks to the antioxidant capacities of its bioactive compounds. The aim of the present study was to evaluate the protective effects of strawberry consumption against oxidative stress induced by Dox in rats. Animals were fed with strawberry enriched diet (15% of the total calories) for two months and Dox (10 mg/kg; i.p.) was injected at the end of the experimental period. Strawberry consumption significantly inhibited ROS production and oxidative damage biomarkers accumulation in plasma and liver tissue and alleviated histopathological changes in rat livers treated with Dox. The reduction of antioxidant enzyme activities was significantly mitigated after strawberry consumption. In addition, strawberry enriched diet ameliorated liver mitochondrial antioxidant levels and functionality. In conclusion, strawberry intake protects against Dox-induced toxicity, at plasma, liver and mitochondrial levels thanks to its high contents of bioactive compounds. metadata Giampieri, Francesca and Alvarez-Suarez, Jose M. and Gasparrini, Massimiliano and Forbes- Hernandez, Tamara Y. and Afrin, Sadia and Bompadre, Stefano and Rubini, Corrado and Zizzi, Antonio and Astolfi, Paola and Santos-Buelga, Celestino and González-Paramás, Ana M. and Quiles, Josè L. and Mezzetti, Bruno and Battino, Maurizio mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, tamara.forbes@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2016) Strawberry consumption alleviates doxorubicin-induced toxicity by suppressing oxidative stress. Food and Chemical Toxicology, 94. pp. 128-137. ISSN 0278-6915

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Cerrado Inglés Glioblastoma multiforme (GBM) are extremely lethal and still poorly treated primary brain tumors, characterized by the presence of highly tumorigenic cancer stem cell (CSC) subpopulations, considered responsible for tumor relapse. In order to successfully eradicate GBM growth and recurrence, new anti-cancer strategies selectively targeting CSCs should be designed. CSCs might be eradicated by targeting some of their cell surface markers and transporters, inducing their differentiation, impacting their hyper-glycolytic metabolism, inhibiting CSC-related signaling pathways and/or by targeting their microenvironmental niche. In this regard, phytocompounds such as curcumin, isothiocyanates, resveratrol and epigallocatechin-3-gallate have been shown to prevent or reverse cancer-related epigenetic dysfunctions, reducing tumorigenesis, preventing metastasis and/or increasing chemotherapy and radiotherapy efficacy. However, the actual bioavailability and metabolic processing of phytocompounds is generally unknown, and the presence of the blood brain barrier often represents a limitation to glioma treatments. Nowadays, nanoparticles (NPs) can be loaded with therapeutic compounds such as phytochemicals, improving their bioavailability and their targeted delivery within the GBM tumor bulk. Moreover, NPs can be designed to increase their tropism and specificity toward CSCs by conjugating their surface with antibodies specific for CSC antigens, with ligands or with glucose analogues. Here we discuss the use of phytochemicals as anti-glioma agents and the applicability of phytochemical-loaded NPs as drug delivery systems to target GBM. Additionally, we provide some examples on how NPs can be specifically formulated to improve CSC targeting. metadata Pistollato, Francesca and Bremer-Hoffmann, Susanne and Basso, Giuseppe and Sumalla Cano, Sandra and Elío Pascual, Iñaki and Masías Vergara, Manuel and Giampieri, Francesca and Battino, Maurizio mail francesca.pistollato@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, sandra.sumalla@uneatlantico.es, inaki.elio@uneatlantico.es, manuel.masias@uneatlantico.es, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es (2016) Targeting Glioblastoma with the Use of Phytocompounds and Nanoparticles. Targeted Oncology, 11 (1). pp. 1-16. ISSN 1776-2596

2015

Article Subjects > Biomedicine Ibero-american International University > Research > Scientific Production Abierto Inglés Strawberry polyphenols have been extensively studied over the last two decades for their beneficial properties. Recently, their possible use in ameliorating skin conditions has also been proposed; however, their role in preventing UVA-induced damage in cosmetic formulation has not yet been investigated. Skin is constantly exposed to several environmental stressors, such as UVA radiation, that induce oxidative stress, inflammation and cell death via the production of reactive oxygen species (ROS). In the present study, we assessed the potential photoprotective capacity of different strawberry-based formulations, enriched with nanoparticles of Coenzyme Q10 and with sun protection factor 10 (SPF10), in human dermal fibroblasts (HuDe) exposed to UVA radiation. We confirmed that strawberries are a very rich source of polyphenols, anthocyanins and vitamins, and possess high total antioxidant capacity. We also showed that strawberry extracts (25 μg/mL–1 mg/mL) exert a noticeable photoprotection in HuDe, increasing cell viability in a dose-dependent way, and that these effects are potentiated by the presence of CoQ10red (100 μg/mL). We have demonstrated for the first time that the topical use of strawberry extract may provide good photoprotection, even if more in-depth studies are strongly encouraged in order to evaluate the cellular and molecular effects of strawberry protection. metadata Gasparrini, Massimiliano and Forbes-Hernandez, Tamara Y. and Afrin, Sadia and Alvarez-Suarez, José and Gonzàlez-Paramàs, Ana and Santos-Buelga, Celestino and Bompadre, Stefano and Quiles, José and Mezzetti, Bruno and Giampieri, Francesca mail UNSPECIFIED, tamara.forbes@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2015) A Pilot Study of the Photoprotective Effects of Strawberry-Based Cosmetic Formulations on Human Dermal Fibroblasts. International Journal of Molecular Sciences, 16 (8). pp. 17870-17884. ISSN 1422-0067

Article Subjects > Biomedicine
Subjects > Nutrition
Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Cerrado Inglés In the last decade, specific dietary patterns, mainly characterized by high consumption of vegetables and fruits, have been proven beneficial for the prevention of both metabolic syndrome (MetS)-related dysfunctions and neurodegenerative disorders, such as Alzheimer’s disease (AD). Nowadays, neuroimaging readouts can be used to diagnose AD, investigate MetS effects on brain functionality and anatomy, and assess the effects of dietary supplementations and nutritional patterns in relation to neurodegeneration and AD-related features. Here we review scientific literature describing the use of the most recent neuroimaging techniques to detect AD- and MetS-related brain features, and also to investigate associations between consolidated dietary patterns or nutritional interventions and AD, specifically focusing on observational and intervention studies in humans. metadata Pistollato, Francesca and Sumalla Cano, Sandra and Elío Pascual, Iñaki and Masías Vergara, Manuel and Giampieri, Francesca and Battino, Maurizio mail francesca.pistollato@uneatlantico.es, sandra.sumalla@uneatlantico.es, inaki.elio@uneatlantico.es, manuel.masias@uneatlantico.es, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es (2015) The Use of Neuroimaging to Assess Associations Among Diet, Nutrients, Metabolic Syndrome, and Alzheimer’s Disease. Journal of Alzheimer's Disease, 48 (2). pp. 303-318. ISSN 13872877

This list was generated on Fri Sep 30 23:40:21 2022 UTC.

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Detection of Upper Limb Asymmetries in Athletes According to the Stage of the Season—A Longitudinal Study

Abstract: Sports injuries can affect the performance of athletes. For this reason, functional tests are used for injury assessment and prevention, analyzing physical or physiological imbalances and detecting asymmetries. The main aim of this study was to detect the asymmetries in the upper limbs (right and left arms) in athletes, using the OctoBalance Test (OB), depending on the stage of the season. Two hundred and fifty-two participants (age: 23.33 ± 8.96 years old; height: 178.63 ± 11.12 cm; body mass: 80.28 ± 17.61 kg; body mass index: 24.88 ± 4.58; sports experience: 12.52 ± 6.28 years), practicing different sports (rugby, athletics, football, swimming, handball, triathlon, basketball, hockey, badminton and volleyball), assessed with the OB in medial, superolateral, and inferolateral directions in both arms, in four moments of the season (May 2017, September 2017, February 2018 and May 2018). ANOVA test was used with repeated measures with a p ≤ 0.05, for the analysis of the different studied variances. Significant differences were found (p = 0.021) in the medial direction of the left arm, between the first (May 2017) and fourth stages (May 2018), with values of 71.02 ± 7.15 cm and 65.03 ± 7.66 cm. From the detection of asymmetries, using the OB to measure, in the medial, superolateral and inferolateral directions, mobility and balance can be assessed. In addition, it is possible to observe functional imbalances, as a risk factor for injury, in each of the stages into which the season is divided, which will help in the prevention of injuries and in the individualization of training.

Producción Científica

Álvaro Velarde-Sotres mail alvaro.velarde@uneatlantico.es, Antonio Bores-Cerezal mail antonio.bores@uneatlantico.es, Marcos Mecías-Calvo mail marcos.mecias@uneatlantico.es, Martín Barcala Furelos mail martin.barcala@uneatlantico.es, Silvia Aparicio Obregón mail silvia.aparicio@uneatlantico.es, Julio Calleja-González mail ,

Velarde-Sotres

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The Regular Consumption of Nuts Is Associated with a Lower Prevalence of Abdominal Obesity and Metabolic Syndrome in Older People from the North of Spain

Background: The aim of this study was to relate the adherence to nut consumption (30 g) three or more days per week to the prevalence of abdominal obesity and metabolic syndrome (MetS) in an elderly population from the north of Spain. Methods: The study consists of an observational, descriptive, cross-sectional, and correlational study conducted in 556 non-institutionalised individuals between 65 and 79 years of age. To define the consumption recommendation of nuts the indication of the questionnaire MEDAS-14 was followed. The diagnosis of MetS was conducted using the International Diabetes Federation (IDF) criteria. Results: In 264 subjects aged 71.9 (SD: ±4.2) years old, 39% of whom were men, the adherence to nut consumption recommendations was 40.2%. Of these individuals, 79.5% had abdominal obesity. The prevalence of MetS was 40.2%, being 47.6% in men and 35.4% in women (p < 0.05). A nut consumption lower than recommended was associated with a 19% higher prevalence of abdominal obesity (Prevalence Ratio: 1.19; 95% CI: 1.03−1.37; p < 0.05) and a 61% higher prevalence of MetS (Prevalence Ratio: 1.61; 95% CI: 1.16−2.25; p = 0.005) compared to a consumption of ≥3 servings per week. Conclusion: An inverse relationship was established between nut consumption and the prevalence of abdominal obesity and metabolic syndrome.

Producción Científica

Gloria Cubas-Basterrechea mail , Iñaki Elío Pascual mail inaki.elio@uneatlantico.es, Sandra Sumalla Cano mail sandra.sumalla@uneatlantico.es, Silvia Aparicio Obregón mail silvia.aparicio@uneatlantico.es, Carolina Teresa González-Antón mail , Pedro Muñoz-Cacho mail ,

Cubas-Basterrechea

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Changes in the Lifestyle of the Spanish University Population during Confinement for COVID-19

The aim of this study was to evaluate the influence of the lockdown due to the COVID-19 pandemic, on eating and physical activity behavior, in a university population. A healthy diet such as the Mediterranean Diet (MD) pattern, rich in fruit and vegetables, can prevent degenerative diseases such as obesity, diabetes, cardiovascular diseases, etc. We conducted a cross-sectional study and data were collected by an anonymous online questionnaire. Participants completed a survey consisting of 3 sections: sociodemographic data; dietary behavior and physical activity; the Mediterranean Diet questionnaire (MEDAS-14) and the Emotional Eater Questionnaire (EEQ). A total of 168 participants completed the questionnaire: 66.7% were women, 79.2% were from Spain, 76.8% were students, 76.2% lived in their family home and 66.1% were of normal weight. During lockdown our population shopped for groceries 1 time or less per week (76.8%); maintained the same consumption of fruits (45.2%), vegetables (50.6%), dairy products (61.9%), pulses (64.9%), fish/seafood (57.7%), white meat (77.4%), red and processed meat (71.4%), pastries and snacks (48.2%), rice/pasta/potatoes (70.2%) and nuts (62.5%), spirits (98.8%) and sugary drinks (91.7%). Cooking time increased (73.2%) and the consumption decreased of low alcohol drinks (60.1%), spirits (75%) and sugary drinks (57.1%), and physical activity also diminished (49.4%). University Employees (UE) gained more weight (1.01 ± 0.02) than students (0.99 ± 0.03) (p < 0.05) during the confinement period. A total of 79.8% of the participants obtained a Medium/High Adherence to the MD during lockdown. Emotional and very emotional eaters were higher in the female group (p < 0.01). In the event of further confinement, strategies should be implemented to promote a balanced and healthy diet together with the practice of physical activity, taking special care of the female and UE groups.

Producción Científica

Sandra Sumalla Cano mail sandra.sumalla@uneatlantico.es, Tamara Forbes-Hernández mail , Silvia Aparicio-Obregón mail silvia.aparicio@uneatlantico.es, Jorge Crespo-Álvarez mail jorge.crespo@uneatlantico.es, Maria Elexpuru Zabaleta mail maria.elexpuru@uneatlantico.es, Mónica Gracia Villar mail monica.gracia@uneatlantico.es, Francesca Giampieri mail francesca.giampieri@uneatlantico.es, Iñaki Elío Pascual mail inaki.elio@uneatlantico.es,

Sumalla Cano

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Psychometric Properties of the Emotional Exhaustion Scale (ECE) in Chilean Higher Education Students

The main objective of this study was to estimate the psychometric properties of the Emotional Fatigue Scale (ECE) in a sample of 1308 Chilean university students and confirm the unifactorial structure of the scale. Exploratory and confirmatory factor analyses were carried out. The ECE assessment had an internal consistency of 0.893 (Cronbach’s Alpha). An exploratory factor analysis with Varimax rotation and a confirmatory analysis were performed, obtaining the factor that explains 52.3% of the variance. The results indicated that the ECE has adequate psychometric properties for use with higher education students in Chile. The ECE scale has good psychometric properties to be applied in the Chilean university context. Its usage may be very relevant to contribute to higher education institutions to emphasize students’ mental health and prevent possible severe pathologies in future professionals. It is suggested to use the ECE scale together with the EES-Int, which is the only interpretation table for this instrument.

Producción Científica

Jonathan Martínez-Líbano mail , María-Mercedes Yeomans mail , Juan-Carlos Oyanedel mail ,

Martínez-Líbano

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Reliability and validity of a clinical competence test for dietitians caring patients with early chronic kidney disease

The aim of the present study was to develop and validate a test to evaluate dietitian's clinical competence (CC) about nutritional care in patients with early chronic kidney disease (CKD). The study was conducted through five steps: (1) CC and its dimensions were defined; (2) test items were elaborated, and choice of response format and scoring system was selected; (3) content and face validity were established; (4) test was subjected to a pilot test and those items with inadequate performance were removed; (5) criterion validity and internal consistency for final validation were established. A 120-items test was developed and applied to 207 dietitians for validation. Dietitians with previous CKD training obtained higher scores than those with no training, confirming the test validity criterion. According to item analysis, Cronbach's α was 0⋅85, difficulty index 0⋅61 ± 0⋅22, discrimination index 0⋅26 ± 0⋅15 and inter-item correlation 0⋅19 ± 0⋅11, displaying adequate internal consistency.

Producción Científica

Roxana M. Márquez-Herrera mail , Laura Cortés-Sanabria mail , Alfonso M. Cueto-Manzano mail , Héctor R. Martínez-Ramírez mail , Enrique Rojas-Campos mail , Nelly Orozco González mail nelly.orozco@unini.edu.mx, Aaron González-Palacios mail ,

Márquez-Herrera