Items where Subject is "Subjects > Nutrition"

2022

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production Abierto Inglés Age-related macular degeneration (AMD) is a serious degenerative disease affecting the eyes, and is the main cause of severe vision loss among people >55 years of age in developed countries. Its onset and progression have been associated with several genetic and lifestyle factors, with diet appearing to play a pivotal role in the latter. In particular, dietary eating patterns rich in plant foods have been shown to lower the risk of developing the disease, and to decrease the odds of progressing to more advanced stages in individuals already burdened with early AMD. We systematically reviewed the literature to analyse the relationship between the adherence to a Mediterranean diet, a mainly plant-based dietary pattern, and the onset/progression of AMD. Eight human observational studies were analysed. Despite some differences, they consistently indicate that higher adherence to a Mediterranean eating pattern lowers the odds of developing AMD and decreases the risk of progression to more advanced stages of the disease, establishing the way for preventative measures emphasizing dietary patterns rich in plant-foods metadata Gastaldello, Annalisa and Giampieri, Francesca and Quiles, José L. and Navarro-Hortal, María D. and Aparicio Obregón, Silvia and García Villena, Eduardo and Tutusaus, Kilian and De Giuseppe, Rachele and Grosso, Giuseppe and Cianciosi, Danila and Forbes-Hernández, Tamara Y. and Nabavi, Seyed M. and Battino, Maurizio mail UNSPECIFIED, francesca.giampieri@uneatlantico.es, jose.quiles@uneatlantico.es, UNSPECIFIED, silvia.aparicio@uneatlantico.es, eduardo.garcia@uneatlantico.es, kilian.tutusaus@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2022) Adherence to the Mediterranean-Style Eating Pattern and Macular Degeneration: A Systematic Review of Observational Studies. Nutrients, 14 (10). p. 2028. ISSN 2072-6643

Article Subjects > Biomedicine
Subjects > Nutrition Ibero-american International University > Research > Scientific Production Abierto Español Introducción: el objetivo del presente trabajo se centra en reconocer la importancia de las investigaciones que relacionan la biodisponibilidad de fósforo en diferentes grupos de alimentos de origen animal, vegetal e industrial y su efecto en la progresión de la enfermedad renal crónica (ERC). Metodología: la revisión se sustentó en la búsqueda literaria en páginas web como PUBMED, Redalyc, SciELO, SCIHUB y Google Academic. Se seleccionó cada estudio, descartando aquellos que no fueran cuantitativos u originales, estuvieran incompletos, sin metodología clara, realizados en mamíferos o si los resultados no se especificaban en porcentajes. La lectura puso especial énfasis en el índice de biodisponibilidad de fósforo derivado del consumo de distintos productos alimenticios. Se elaboraron tres matrices de acuerdo con el origen del comestible y la biodisponibilidad de fósforo que absorbe el organismo. Resultados: se encontró que los alimentos industrializados y los aditivos muestran una biodisponibilidad de fósforo del 90 % al 100 %, los de origen animal del 40 % al 80 % y los de origen vegetal del 30 %. Conclusiones: los aditivos de los alimentos industrializados promueven la hiperfosfatemia y, con ello, aceleran la progresión de la enfermedad renal crónica, a diferencia de los de origen animal y vegetal, menos perjudiciales para la salud. Esto da pauta a la formación del sector salud para ampliar su conocimiento sobre el tratamiento nutricional del paciente. metadata Martínez Hernández, Eduardo and De La Luz Maya, Rodolfo A. and Ramírez Robledo, María De Los Á and Núñez-Murillo, Gabriela K. and Orozco González, Nelly mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, nelly.orozco@unini.edu.mx (2022) Biodisponibilidad de fósforo en alimentos y su efecto en la enfermedad renal crónica. Población y Salud en Mesoamérica, 19 (2). pp. 293-320.

Article Subjects > Nutrition Ibero-american International University > Research > Scientific Production Abierto Español Introducción: la pandemia por COVID-19 ha obligado a los gobiernos de los países afectados a aplicar medidas preventivas que incluyen la cuarentena o el confinamiento domiciliario. Se ha visto que, en general, esta situación ha afectado los patrones alimentarios de la población. Objetivo: evaluar los cambios en los hábitos alimentarios y en la adquisición de los alimentos durante las diferentes etapas del confinamiento domiciliario ocasionado por COVID-19 en la población adulta de alto nivel educativo en diferentes países de Iberoamérica. Métodos: se realizó un estudio observacional y transversal en el que participaron 9.572 personas de 58 países diferentes con estudios universitarios. El instrumento utilizado para la recolección de datos fue una encuesta diseñada por la Universidad Internacional Iberoamericana de México (UNINI-México) para estudiar los hábitos alimentarios durante el confinamiento domiciliario por COVID-19 como parte del estudio HALCON-COVID-19. Resultados: la mayoría de los encuestados indicaron haber mantenido su peso durante la cuarentena (57,3 %), aunque reportan haber reducido su actividad física (23,9 %) y han eliminado el consumo de alimentos ultraprocesados (53,4 %), de bebidas alcohólicas (43,3 %) y de chocolates y golosinas (41,1 %), mientras que incluyeron en su dieta vegetales (37,7 %), frutas (37 %) y huevos (30,6 %). Conclusiones: las personas que usualmente no comen saludablemente han visto aún más afectada su forma de alimentarse durante el confinamiento, reduciendo su actividad física e incrementando su peso corporal, mientras que aquellas con estilos de vida más sanos no han cambiado sus hábitos o incluso han mantenido sus estilos de vida saludable durante la pandemia. metadata Muñoz Salvador, Luisa and Briones Urbano, Mercedes and Pérez, Yago mail UNSPECIFIED, mercedes.briones@uneatlantico.es, UNSPECIFIED (2022) Cambios en el comportamiento alimentario de personas adultas con elevado nivel académico durante las diferentes etapas del confinamiento domiciliario por COVID-19 en Iberoamérica. Nutrición Hospitalaria. ISSN 0212-1611

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Inglés The aim of this study was to evaluate the influence of the lockdown due to the COVID-19 pandemic, on eating and physical activity behavior, in a university population. A healthy diet such as the Mediterranean Diet (MD) pattern, rich in fruit and vegetables, can prevent degenerative diseases such as obesity, diabetes, cardiovascular diseases, etc. We conducted a cross-sectional study and data were collected by an anonymous online questionnaire. Participants completed a survey consisting of 3 sections: sociodemographic data; dietary behavior and physical activity; the Mediterranean Diet questionnaire (MEDAS-14) and the Emotional Eater Questionnaire (EEQ). A total of 168 participants completed the questionnaire: 66.7% were women, 79.2% were from Spain, 76.8% were students, 76.2% lived in their family home and 66.1% were of normal weight. During lockdown our population shopped for groceries 1 time or less per week (76.8%); maintained the same consumption of fruits (45.2%), vegetables (50.6%), dairy products (61.9%), pulses (64.9%), fish/seafood (57.7%), white meat (77.4%), red and processed meat (71.4%), pastries and snacks (48.2%), rice/pasta/potatoes (70.2%) and nuts (62.5%), spirits (98.8%) and sugary drinks (91.7%). Cooking time increased (73.2%) and the consumption decreased of low alcohol drinks (60.1%), spirits (75%) and sugary drinks (57.1%), and physical activity also diminished (49.4%). University Employees (UE) gained more weight (1.01 ± 0.02) than students (0.99 ± 0.03) (p < 0.05) during the confinement period. A total of 79.8% of the participants obtained a Medium/High Adherence to the MD during lockdown. Emotional and very emotional eaters were higher in the female group (p < 0.01). In the event of further confinement, strategies should be implemented to promote a balanced and healthy diet together with the practice of physical activity, taking special care of the female and UE groups. metadata Sumalla Cano, Sandra and Forbes-Hernández, Tamara and Aparicio-Obregón, Silvia and Crespo-Álvarez, Jorge and Elexpuru Zabaleta, Maria and Gracia Villar, Mónica and Giampieri, Francesca and Elío Pascual, Iñaki mail sandra.sumalla@uneatlantico.es, UNSPECIFIED, silvia.aparicio@uneatlantico.es, jorge.crespo@uneatlantico.es, maria.elexpuru@uneatlantico.es, monica.gracia@uneatlantico.es, francesca.giampieri@uneatlantico.es, inaki.elio@uneatlantico.es (2022) Changes in the Lifestyle of the Spanish University Population during Confinement for COVID-19. International Journal of Environmental Research and Public Health, 19 (4). p. 2210. ISSN 1660-4601

Article Subjects > Biomedicine
Subjects > Nutrition Ibero-american International University > Research > Scientific Production Abierto Inglés The authors regret the incorrect publication of the actual affiliation for the author José Ramos-Vivas in the original article. The corrected affiliation is provided below: Luis Monzón-Atienzaa, Jimena Bravoa, Álvaro Fernández-Monteroa, Ives Charlie-Silvab, Daniel Monteroa, José Ramos-Vivasa,d,e, Jorge Galindo-Villegasc,*, Félix Acostaa aGrupo de Investigaci'on en Acuicultura (GIA), Instituto Ecoaqua, Universidad de Las Palmas de Gran Canaria, Spain bDepartment of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil cFaculty of Biosciences and Aquaculture, Nord University, Bodø, Norway dResearch Group on Foods, Nutritional Biochemistry and Health, Universidad Europea del Atlántico, 39011 Santander, Spain eDepartment of Project Management, Universidad Internacional Iberoamericana, Campeche 24560, Mexico The authors would like to apologise for any inconvenience caused. metadata Monzón-Atienza, Luis and Bravo, Jimena and Fernández-Montero, Álvaro and Charlie-Silva, Ives and Montero, Daniel and Ramos Vivas, Jose and Galindo-Villegas, Jorge and Acosta, Félix mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, jose.ramos@uneatlantico.es, UNSPECIFIED, UNSPECIFIED (2022) Corrigendum to “Dietary supplementation of Bacillus velezensis improves Vibrio anguillarum clearance in European sea bass by activating essential innate immune mechanisms” [Fish Shellfish Immunol. 124 (2022) 244–253]. Fish & Shellfish Immunology. ISSN 10504648

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Inglés Background: The aim of this study was to relate the adherence to nut consumption (30 g) three or more days per week to the prevalence of abdominal obesity and metabolic syndrome (MetS) in an elderly population from the north of Spain. Methods: The study consists of an observational, descriptive, cross-sectional, and correlational study conducted in 556 non-institutionalised individuals between 65 and 79 years of age. To define the consumption recommendation of nuts the indication of the questionnaire MEDAS-14 was followed. The diagnosis of MetS was conducted using the International Diabetes Federation (IDF) criteria. Results: In 264 subjects aged 71.9 (SD: ±4.2) years old, 39% of whom were men, the adherence to nut consumption recommendations was 40.2%. Of these individuals, 79.5% had abdominal obesity. The prevalence of MetS was 40.2%, being 47.6% in men and 35.4% in women (p < 0.05). A nut consumption lower than recommended was associated with a 19% higher prevalence of abdominal obesity (Prevalence Ratio: 1.19; 95% CI: 1.03−1.37; p < 0.05) and a 61% higher prevalence of MetS (Prevalence Ratio: 1.61; 95% CI: 1.16−2.25; p = 0.005) compared to a consumption of ≥3 servings per week. Conclusion: An inverse relationship was established between nut consumption and the prevalence of abdominal obesity and metabolic syndrome. metadata Cubas-Basterrechea, Gloria and Elío Pascual, Iñaki and Sumalla Cano, Sandra and Aparicio Obregón, Silvia and González-Antón, Carolina Teresa and Muñoz-Cacho, Pedro mail UNSPECIFIED, inaki.elio@uneatlantico.es, sandra.sumalla@uneatlantico.es, silvia.aparicio@uneatlantico.es, UNSPECIFIED, UNSPECIFIED (2022) The Regular Consumption of Nuts Is Associated with a Lower Prevalence of Abdominal Obesity and Metabolic Syndrome in Older People from the North of Spain. International Journal of Environmental Research and Public Health, 19 (3). p. 1256. ISSN 1660-4601

Article Subjects > Nutrition Ibero-american International University > Research > Scientific Production Abierto Inglés The aim of the present study was to develop and validate a test to evaluate dietitian's clinical competence (CC) about nutritional care in patients with early chronic kidney disease (CKD). The study was conducted through five steps: (1) CC and its dimensions were defined; (2) test items were elaborated, and choice of response format and scoring system was selected; (3) content and face validity were established; (4) test was subjected to a pilot test and those items with inadequate performance were removed; (5) criterion validity and internal consistency for final validation were established. A 120-items test was developed and applied to 207 dietitians for validation. Dietitians with previous CKD training obtained higher scores than those with no training, confirming the test validity criterion. According to item analysis, Cronbach's α was 0⋅85, difficulty index 0⋅61 ± 0⋅22, discrimination index 0⋅26 ± 0⋅15 and inter-item correlation 0⋅19 ± 0⋅11, displaying adequate internal consistency. metadata Márquez-Herrera, Roxana M. and Cortés-Sanabria, Laura and Cueto-Manzano, Alfonso M. and Martínez-Ramírez, Héctor R. and Rojas-Campos, Enrique and Orozco González, Nelly and González-Palacios, Aaron mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, nelly.orozco@unini.edu.mx, UNSPECIFIED (2022) Reliability and validity of a clinical competence test for dietitians caring patients with early chronic kidney disease. Journal of Nutritional Science, 11. ISSN 2048-6790

Article Subjects > Nutrition Ibero-american International University > Research > Scientific Production Abierto Inglés Background & aims Evidence suggests that multiple-behavior interventions (with a specialist) have a greater impact on public health than single-behavior interventions, particularly in a chronic patient. However, there is little understanding of some very basic principles concerning multiple health behavior change, especially in situations such as kidney transplantation, which requires a great willingness to change negative lifestyle behaviors to achieve intermediate and long-term success. We compared healthy lifestyles and nutritional status according to the willingness to change dietary and exercise behavior in dialysis patients from a living donor kidney transplant program. Methods 400 dialysis patients had a dietetic, anthropometric, protein-energy wasting [subjective global assessment (SGA)] and biochemical evaluation. Lifestyle was evaluated with an adapted instrument to measure lifestyle in chronic disease. Willingness to change behaviors was evaluated by the trans-theoretical model; 2 groups were formed: willingness to change dietary and exercise behaviors and unwillingness to change. Results Willingness to change dietary behavior was 50% and exercise 25%. Patients with willingness to change dietary and exercise behaviors had better healthy lifestyle scores, and higher frequency of healthy food consumption. Healthy lifestyle score (R2 = 0.37, p < 0.0001) was predicted by older age, higher educational degree, shorter time on dialysis, and the highest willingness to change dietary and exercise behaviors. Conclusions Willingness to change dietary and exercise behaviors was associated with healthy lifestyle, as well as with higher frequency of healthy food consumption and with lower frequency of unhealthy food consumption. metadata Orozco González, Nelly and Cortés-Sanabria, Laura and Márquez-Herrera, Roxana M. and Martín-del-Campo-López, Fabiola and Gómez-García, Erika F. and Rojas-Campos, Enrique and Gómez-Navarro, Benjamín and Cueto-Manzano, Alfonso M. mail nelly.orozco@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2022) Willingness to change diet and exercise behavior is associated with better lifestyle in dialysis patients close to a kidney transplant. Clinical Nutrition ESPEN, 47. pp. 277-282. ISSN 24054577

2021

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Cerrado Inglés BACKGROUND:In Spain, there are several studies published on the relationship between eating habits and lifestyle among university students; but only a few of them are focused on online postgraduate students. OBJECTIVE:Herein we aimed to evaluate the degree of adherence to the Mediterranean diet pyramid (2010 edition), non-communicable diseases (NCDs), and lifestyle in online postgraduate students aged 20–65 years belonging to the food area of the Fundación Universitaria Iberoamericana (FUNIBER). METHODS:We performed a descriptive cross-sectional study including 100 online post-graduate students aged 20–65 years who were recruited by an accidental non-probabilistic sampling method consisting of a questionnaire on their sociodemographic characteristics, NCDs, lifestyle, and a 3-day food intake record (3-d). RESULTS:The profile of the students was 74% women, with a mean age of 36.6 (±10.5) years and body mass index (BMI) of 22.6 kg / m2 (±3.3). 71% of the volunteers presented normal weight, while 20% were overweight. Indeed, only a low percentage of the volunteers presented hypertension (1%), cardiovascular disease (0%), diabetes mellitus 1 (2%), diabetes mellitus 2 (3%), hypercholesterolemia (9%), and hyperuricemia (2%). Concerning lifestyle, (77%) of students were non-smokers, (78%) consumed beverages with caffeine, (51%) did not consume alcoholic beverages, and nearly all of them (84%) frequently (3 times /week) practiced physical activity. 68% of the recruited students exhibited adherence to “Medium diet quality diet (4–7)” followed by (26%) with a “Poor diet quality (<3)” and “Optimal diet quality” (6%). CONCLUSIONS:Spanish postgraduate students of the nutritional area, have good health and a healthy lifestyle but are moving away from the MD model, should be established campaigns for the improvement of eating habits of the postgraduate university population. metadata Elío Pascual, Iñaki and Jarrin, Sandra and Elexpuru Zabaleta, Maria and Crespo-Álvarez, Jorge and Dominguez Azpíroz, Irma and Tutusaus, Kilian and Ruiz Salces, Roberto and Calderón Iglesias, Rubén and Sumalla Cano, Sandra mail inaki.elio@uneatlantico.es, sandra.jarrin@uneatlantico.es, maria.elexpuru@uneatlantico.es, jorge.crespo@uneatlantico.es, irma.dominguez@uneatlantico.es, kilian.tutusaus@uneatlantico.es, roberto.ruiz@uneatlantico.es, ruben.calderon@uneatlantico.es, sandra.sumalla@uneatlantico.es (2021) Adherence to the pyramid of the Mediterranean diet (2010), non-communicable diseases and lifestyle in online postgraduate Spanish students in the food area. Mediterranean Journal of Nutrition and Metabolism, 14 (2). pp. 191-205. ISSN 1973798X

Article Subjects > Nutrition Ibero-american International University > Research > Scientific Production Abierto Español La diabetes mellitus tipo 2 (DM2) es uno de los principales problemas epidemiológicos debido a la naturaleza compleja de la enfermedad. En el plano de atención individual, es necesario llevar a cabo intervenciones nutricionales y promover hábitos de alimentación saludables, utilizando herramientas que permitan una adecuada adherencia a dichas medidas. El objetivo de esta revisión es identificar, a través del análisis de la literatura, las estrategias dietéticas para el control de la DM2 y compararlas según su eficacia para lograr la adherencia del paciente. metadata Orozco González, Nelly and Vieyra-Angeles, Carolina and Rojo-López, Marina Idalia and Aguilar-Aguayo, Leticia and Camacho-López, Saby mail nelly.orozco@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2021) Adherencia a las intervenciones dietéticas en pacientes con diabetes mellitus tipo 2: una revisión narrativa de la literatura. Revista de Nutrición Clínica y Metabolismo, 4 (3). pp. 51-61. ISSN 2619564X

Article Subjects > Nutrition Ibero-american International University > Research > Scientific Production Abierto Inglés Background: DNA methylation is the best epigenetic mechanism for explaining the interactions between nutrients and genes involved in intrauterine growth and development programming. A possible contributor of methylation abnormalities to congenital heart disease is the folate methylation regulatory pathway; however, the mechanisms and methylation patterns of VSD-associated genes are not fully understood. Objective: To determine if maternal dietary intake of folic acid (FA) is related to the methylation status (MS) of VSD-associated genes (AXIN1, MTHFR, TBX1, and TBX20). Methods: Prospective case–control study; 48 mothers and their children were evaluated. The mothers’ dietary variables were collected through a food frequency questionnaire focusing on FA and the consumption of supplements with FA. The MS of promoters of genes was determined in the children. Results: The intake of FA supplements was significantly higher in the control mothers. In terms of maternal folic acid consumption, significant differences were found in the first trimester of pregnancy. Significant differences were observed in the MS of MTHFR and AXIN1 genes in VSD and control children. A correlation between maternal FA supplementation and MS of AXIN1 and TBX20 genes was found in control and VSD children, respectively. Conclusions: A lower MS of AXIN1 genes and a higher MS of TBX20 genes is associated with FA maternal supplementation. metadata González-Peña, Sandra M. and Calvo-Anguiano, Geovana and Martínez-de-Villarreal, Laura E. and Ancer-Rodríguez, Patricia R. and Lugo-Trampe, José J. and Saldivar-Rodríguez, Donato and Hernández-Almaguer, María D. and Calzada-Dávila, Melissa and Guerrero-Orjuela, Ligia S. and Campos-Acevedo, Luis D. mail UNSPECIFIED (2021) Maternal Folic Acid Intake and Methylation Status of Genes Associated with Ventricular Septal Defects in Children: Case–Control Study. Nutrients, 13 (6). p. 2071. ISSN 2072-6643

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Inglés In recent times, scientific attention has been paid to different foods and their bioactive components for the ability to inhibit the onset and progress of different types of cancer. Nigella sativa extract, powder and seed oil and its main components, thymoquinone and α-hederin, have showed potent anticancer and chemosensitizing effects against various types of cancer, such as liver, colon, breast, renal, cervical, lung, ovarian, pancreatic, prostate and skin tumors, through the modulation of various molecular signaling pathways. Herein, the purpose of this review was to highlight the anticancer activity of Nigella sativa and it constitutes, focusing on different in vitro, in vivo and clinical studies and projects, in order to underline their antiproliferative, proapoptotic, cytotoxic and antimetastatic effects. Particular attention has been also given to the synergistic effect of Nigella sativa and it constitutes with chemotherapeutic drugs, and to the synthesized analogs of thymoquinone that seem to enhance the chemo-sensitizing potential. This review could be a useful step towards new research on N. sativa and cancer, to include this plant in the dietary treatments in support to conventional therapies, for the best achievement of therapeutic goals. metadata Ansary, Johura and Giampieri, Francesca and Forbes-Hernandez, Tamara Y. and Regolo, Lucia and Quinzi, Denise and Gracia Villar, Santos and Garcia Villena, Eduardo and Tutusaus, Kilian and Alvarez-Suarez, José M. and Battino, Maurizio and Cianciosi, Danila mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, santos.gracia@uneatlantico.es, eduardo.garcia@uneatlantico.es, kilian.tutusaus@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2021) Nutritional Value and Preventive Role of Nigella sativa L. and Its Main Component Thymoquinone in Cancer: An Evidenced-Based Review of Preclinical and Clinical Studies. Molecules, 26 (8). p. 2108. ISSN 1420-3049

Article Subjects > Nutrition Ibero-american International University > Research > Scientific Production Cerrado Inglés A procedure easy to upscale industrially aimed at obtaining resistant starch (RS) type III (RS-III) was optimized, using a native faba bean from Mexico (Vicia faba L. creole) as RS source for the first time. Pullulanase debranching treatment (6–18 enzyme units (U)/g starch; 0–27 h) and retrogradation process (−30 °C, 2 °C or 20 °C; 1–6 days) was optimized for faba beans. Optimal conditions were determined at 18 U/g for 27 h and a retrogradation process at 20 °C for 6 days. Obtained faba bean RS was also compared with RS obtained from conventional sources, beans (Phaseolus vulgaris L. Jamapa) and maize, under these optimal conditions. Beans (faba beans, 64.88%; beans, 64.84%) yielded greater RS-III than maize (58.44%). The retrogradation process increased the crystallinity structure of the RS samples compared to their respective NS. Typical legume C pattern (faba bean and beans) and cereal A pattern (maize) of samples changed to an irregular polymorphic morphology type B + V, caused by retrogradation, and increasing RS content. As consequence, the digestibility of the retrograded samples was significantly reduced (approximately 50%) and increasing the amount of slow digestible starch fraction (SDS). metadata Suárez-Diéguez, Teodoro and Pérez-Moreno, Fidel and Ariza-Ortega, José Alberto and López-Rodríguez, Guadalupe and Nieto, Juan Antonio mail UNSPECIFIED (2021) Obtention and characterization of resistant starch from creole faba bean (Vicia faba L. creole) as a promising functional ingredient. LWT, 145. p. 111247. ISSN 00236438

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Inglés Presently, biopreservation through protective bacterial cultures and their antimicrobial products or using antibacterial compounds derived from plants are proposed as feasible strategies to maintain the long shelf-life of products. Another emerging category of food biopreservatives are bacteriophages or their antibacterial enzymes called “phage lysins” or “enzybiotics”, which can be used directly as antibacterial agents due to their ability to act on the membranes of bacteria and destroy them. Bacteriophages are an alternative to antimicrobials in the fight against bacteria, mainly because they have a practically unique host range that gives them great specificity. In addition to their potential ability to specifically control strains of pathogenic bacteria, their use does not generate a negative environmental impact as in the case of antibiotics. Both phages and their enzymes can favor a reduction in antibiotic use, which is desirable given the alarming increase in resistance to antibiotics used not only in human medicine but also in veterinary medicine, agriculture, and in general all processes of manufacturing, preservation, and distribution of food. We present here an overview of the scientific background of phages and enzybiotics in the food industry, as well as food applications of these biopreservatives. metadata Ramos Vivas, Jose and Elexpuru Zabaleta, Maria and Sámano Celorio, María Luisa and Pascual Barrera, Alina Eugenia and Forbes-Hernandez, Tamara Y. and Giampieri, Francesca and Battino, Maurizio mail jose.ramos@uneatlantico.es, maria.elexpuru@uneatlantico.es, marialuisa.samano@uneatlantico.es, alina.pascual@unini.edu.mx, tamara.forbes@unini.edu.mx, UNSPECIFIED, UNSPECIFIED (2021) Phages and Enzybiotics in Food Biopreservation. Molecules, 26 (17). p. 5138. ISSN 1420-3049

Thesis Subjects > Nutrition Ibero-american International University > Research > Doctoral Thesis Abierto Español La Universidad Centroamericana (UCA) en el Programa “Campus Saludable”, incorpora el concepto de promoción de la salud y estilo de vida saludable para facilitar el desarrollo humano y mejorar la calidad de vida de la población universitaria. El objetivo del estudio fue analizar el impacto de este programa en la adopción y etapa del cambio de comportamiento alimentario de la dieta utilizando el modelo transteórico. El estudio es descriptivo y transversal, participaron 119 personas, 60 estudiantes y 59 trabajadores. Los datos se analizaron en el programa SPSS 20 mediante frecuencia, porcentajes, pruebas chi cuadrado y t de Student. Las etapas de cambio de la dieta, se evaluaron según un algoritmo de 5 clasificaciones: precontemplación, contemplación, preparación, acción y mantenimiento. Mediante una encuesta electrónica se indagaron motivaciones, barreras, percepciones, preferencias de consumo de alimentos y la adopción de comportamientos alimentarios como: aumento en el consumo de frutas y vegetales, disminución de grasas y azúcares, realización del desayuno y utilización del tamaño de las porciones. Las motivaciones de tener buena salud y hábitos alimentarios saludables son las más mencionadas por ambos grupos, para favorecer la adopción de los comportamientos alimentarios saludables. El 93 % de los participantes adoptaron algún comportamiento alimentario y de acuerdo al modelo transteórico, en tres de estos la mayor parte lograron alcanzar las etapas de acción y mantenimiento. Se encontró diferencia significativa entre estudiantes y trabajadores en la realización del desayuno (p<0.05), en cuanto al sexo, el aumento de frutas y vegetales no mostró diferencia significativa (p>0.05). metadata Reyes Cardoza, Carmen Maria mail cmreyes6@gmail.com (2021) Programa "Campus Saludable" y cambios en la dieta y los comportamientos alimentarios adoptados por sus beneficiarios estudiantes y trabajadores de la Universidad Centroamericana de Nicaragua. Doctoral thesis, Universidad Internacional Iberoamericana México.

Article Subjects > Biomedicine
Subjects > Nutrition Ibero-american International University > Research > Scientific Production Abierto Inglés Protein-energy wasting (PEW) and poor health-related quality of life (HRQoL) are independently associated with morbi-mortality in continuous ambulatory peritoneal dialysis (CAPD). PEW may reduce HRQoL; however, we hypothesized HRQoL is affected differentially by PEW degrees or by individual criteria of nutritional status. Aim To evaluate HRQoL according to PEW severity and nutritional status indicators in CAPD. This is a cross-sectional study in 151 patients. Subjective global assessment (SGA) was employed, and nutritional status classified as normal, mild-moderate PEW, and severe PEW. HRQoL was evaluated using Kidney Disease Quality of Life Short Form™, including physical (PCS), mental (MCS) and kidney disease (KDCS) components, and their subscales. Dietary intake, anthropometric and biochemical variables were measured. Forty-six percent of patients were well-nourished, 44% had mild-moderate PEW, and 10% severe PEW. Compared with well-nourished patients, those with mild-moderate (p = 0.06) and severe (p = 0.005) PEW had lower HRQoL score [68 (52–75), 55 (45–72), 46 (43–58), respectively]. PCS, MCS, and KDCS and their subscales had lower values as PEW was more severe. Patients with obesity and hypoalbuminemia had significantly lower HRQoL overall and component scores than their counterparts. Dietary intake was not associated with quality of life. In multivariate analysis obesity, PEW (by SGA), hypoalbuminemia, and low educational level predicted poor HRQoL (χ2 58.2, p < 0.0001). As conclusion, PEW severity was related with worse HRQoL, either as overall score or in every component or subscale in CAPD patients. Poor HRQoL was predicted independently by PEW severity and obesity; additional predictors were hypoalbuminemia and low education. metadata Orozco González, Nelly and Márquez-Herrera, Roxana M. and Cortés-Sanabria, Laura and Cueto-Manzano, Alfonso M. and Gutiérrez-Medina, Margarita and Gómez-García, Erika F. and Rojas-Campos, Enrique and Paniagua-Sierra, José R. and Martín del Campo, Fabiola mail nelly.orozco@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2021) Severity of protein-energy wasting and obesity are independently related with poor quality of life in peritoneal dialysis patients. Nefrología. ISSN 02116995

2020

Article Subjects > Biomedicine
Subjects > Nutrition Ibero-american International University > Research > Scientific Production Cerrado Inglés Objective: The aim of this study was to validate a direct taste perception test (TPT) and evaluate its performance in patients on dialysis. Methods: This cross-sectional study was carried out in a tertiary-care hospital. A TPT was validated on 112 healthy subjects and applied on 43 patients on hemodialysis and 32 patients on peritoneal dialysis. All participants were presented a 10-mL sample to identify and rate intensity of primary tastes: sweet (sucrose 2%), sour (citric acid 0.1%), bitter (caffeine 0.06%), salty (sodium chloride 0.5%), and umami (sodium glutamate 0.25%). The internal consistency and repeatability of TPT was assessed by Cronbach's alpha and intraclass correlation coefficient. Chi-square and Mann-Whitney U tests were used to compare groups. Results: TPT had Cronbach's alpha of 0.77. Intraclass correlation coefficient was 0.74 for sweet, P < .0001; 0.57 for salty, P = .001; 0.62 for sour, P < .0001; 0.78 for bitter, P < .0001; and 0.76 for umami, P < .0001. Compared with controls, patients on peritoneal dialysis were less able to identify sweet and umami tastes (P < .05) and marginally (P = .06) sour taste, whereas patients on hemodialysis were marginally (P = .06) less able to identify sweet and salty tastes. Bitter was not differently identified between groups. According to the visual analog scale (0-10), all patients on dialysis perceived sour taste less intensely than control subjects (P < .05). Conclusions: This TPT for patients on dialysis had adequate reliability to identify five primary tastes in a clinical setting. Except for bitter taste, perception of all the primary tastes was altered in patients on dialysis compared with control subjects. A broader use of this test would help identify taste alterations and implement strategies for malnutrition. metadata Márquez-Herrera, Roxana M. and Núñez-Murillo, Gabriela K. and Ruíz-Gurrola, Claudia G. and Gómez-García, Erika F. and Orozco-González, Claudia N. and Cortes-Sanabria, Laura and Cueto-Manzano, Alfonso M. and Rojas-Campos, Enrique mail UNSPECIFIED (2020) Clinical Taste Perception Test for Patients With End-Stage Kidney Disease on Dialysis. Journal of Renal Nutrition, 30 (1). pp. 79-84. ISSN 10512276

2019

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Cerrado Inglés Significance: In eukaryotes, autophagy represents a highly evolutionary conserved process, through which macromolecules and cytoplasmic material are degraded into lysosomes and recycled for biosynthetic or energetic purposes. Dysfunction of the autophagic process has been associated with the onset and development of many human chronic pathologies, such as cardiovascular, metabolic, and neurodegenerative diseases as well as cancer. Recent Advances: Currently, comprehensive research is being carried out to discover new therapeutic agents that are able to modulate the autophagic process in vivo. Recent evidence has shown that a large number of natural bioactive compounds are involved in the regulation of autophagy by modulating several transcriptional factors and signaling pathways. Critical Issues: Critical issues that deserve particular attention are the inadequate understanding of the complex role of autophagy in disease pathogenesis, the limited availability of therapeutic drugs, and the lack of clinical trials. In this context, the effects that natural bioactive compounds exert on autophagic modulation should be clearly highlighted, since they depend on the type and stage of the pathological conditions of diseases. Future Directions: Research efforts should now focus on understanding the survival-supporting and death-promoting roles of autophagy, how natural compounds interact exactly with the autophagic targets so as to induce or inhibit autophagy and on the evaluation of their pharmacological effects in a more in-depth and mechanistic way. In addition, clinical studies on autophagy-inducing natural products are strongly encouraged, also to highlight some fundamental aspects, such as the dose, the duration, and the possible synergistic action of these compounds with conventional therapy. metadata Giampieri, Francesca and Afrin, Sadia and Forbes-Hernandez, Tamara Y. and Gasparrini, Massimiliano and Cianciosi, Danila and Reboredo-Rodriguez, Patricia and Varela-Lopez, Alfonso and Quiles, Jose L. and Battino, Maurizio mail UNSPECIFIED, UNSPECIFIED, tamara.forbes@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2019) Autophagy in Human Health and Disease: Novel Therapeutic Opportunities. Antioxidants & Redox Signaling, 30 (4). pp. 577-634. ISSN 1523-0864

Article Subjects > Social Sciences
Subjects > Nutrition Ibero-american International University > Research > Scientific Production Abierto Español Introducción: Las estrategias nutricionales y dietéticas tienen por objetivo mejorar la salud. Los estudios de costos económicos permiten evaluar intervenciones, así como observar los costos y los beneficios. Se han desarrollado estrategias nutricionales cuyo costo sea bajo y cuya efectividad sea alta para disminuir la incidencia de enfermedades, por lo que desempeñan un papel importante en la recuperación y preservación de la salud. Material y métodos: Se realizó una búsqueda sistemática en las diferentes bases de datos, en la cual se incluyeron artículos costo-efectividad desde el punto de vista institucional, de intervenciones nutricionales y dietéticas desde 1980 a 2018. Los estudios se agruparon de acuerdo al tipo de intervención. Se comparó el objetivo de cada estudio con las diferencias de los estudios de simulación y de los estudios clínico-económicos. Resultados: Se incluyeron 34 artículos. Todos eran ensayos clínicos aleatorizados, tanto en los estudios tomados de la literatura para hacer los estudios de simulación como en los estudios clínico-económico. Conclusiones: No todas las publicaciones reportan las unidades de efectividad en el mismo sistema monetario, ni definen efectividad de la misma manera, sin embargo, las estrategias de intervención nutricionales y dietéticas demuestran ser efectivas al reducir los días de hospitalización y al mejorar los pronósticos vitales y el estado de salud en general de los pacientes, por lo que su costo no solo es amortizable, sino que debería considerarse como parte esencial de las intervenciones sanitarias. metadata Rojo-López, Marina and Franco-Jimenez, J. Alfonso and Orozco González, Nelly mail marina.rojo@unini.edu.mx, UNSPECIFIED, nelly.orozco@unini.edu.mx (2019) Costo-efectividad de las intervenciones nutricias y dietéticas en salud. Población y Salud en Mesoamérica. ISSN 1659-0201

Thesis Subjects > Biomedicine
Subjects > Physical Education and Sport
Subjects > Nutrition Ibero-american International University > Research > Doctoral Thesis Cerrado Español Actualmente la obesidad infantil es considerada como la pandemia del siglo XXI, con una alta prevalencia mundial, aumentando de 32 millones en 1990 a 41 millones en el año 2016. Es de origen multifactorial con intervención de factores genéticos, ambientales y conductuales. Está asociada a una amplia gama de complicaciones multiorgánicas graves y a un creciente riesgo de desarrollar tempranamente enfermedades crónicas no transmisibles como la diabetes mellitus y enfermedades cardiovasculares que son la principal causa de mortalidad y discapacidad en la adultez. Según la OMS, si continúa esta alta prevalencia, se estima que habrá 70 millones de niños con obesidad infantil para el año 2025. Las estrategias más efectivas de prevención son las que asocian varios componentes y para que sean más eficaces deben incorporar a la familia e iniciarse precozmente. El objetivo de esta investigación fue diseñar un Plan Estratégico de Prevención de Sobrepeso y Obesidad infantil en el Hospital General del Instituto Ecuatoriano de Seguridad Social (IESS) Quevedo, el cual, permitió brindar un tratamiento oportuno con la finalidad de prevenir las complicaciones a corto, mediano y largo plazo. Se evaluó la efectividad del Plan Estratégico mediante la validación del cuestionario con el programa informático Statistical Package for the Social Sciences (SPSS), corroborando el efecto que las intervenciones educativas tuvieron en la modificación o adquisición de hábitos alimentarios y actividad física. Se obtuvieron importantes resultados: las charlas del Club de Nutrición Infantil tuvieron una gran acogida entre los afiliados, los temas impartidos permitieron aclarar conceptos acerca de una nutrición saludable, y conocer cómo mejorar su estilo de vida. Además, se concientizó a los afiliados acerca de la importancia de disminuir el consumo de sal, azúcares refinadas y grasas saturadas, y aumentar el consumo de agua, frutas, verduras y legumbres que se pudo comprobar posterior a la intervención educativa. metadata Díaz Olmedo, Cecilia Maribel mail cm.diaz@hotmail.es (2019) Diseño de un plan estratégico para la prevención de sobrepeso y obesidad infantil en Quevedo-Ecuador. Doctoral thesis, Universidad Internacional Iberoamericana México.

2018

Thesis Subjects > Nutrition Ibero-american International University > Research > Doctoral Thesis Cerrado Portugués Já lá vão décadas em que a pobreza, insegurança alimentar e malnutrição em África foram sempre vistas como sendo problemas das zonas rurais. A partir do final do século XX, devido a rápida urbanização na África Subsaariana, as zonas urbanas foram sendo severamente atingidas pela pobreza, de maneira que os meios de subsistência, segurança alimentar e nutricional foram se tornando escassos. Moçambique é exemplo desses países, estando entre 10 países mais pobres do mundo, de 185 países avaliados pelo Programa das Nações Unidas para o Desenvolvimento. Os índices globais de desnutrição globais continuam elevados. “Atualmente, vivem no mundo cerca de 7 bilhões de habitantes, dos quais perto de 11% são desnutridas correspondendo à 795 milhões de indivíduos, dos quais, 220 milhões encontram-se na África Subsaariana” (FAO, FIDA, & PMA, 2015, p.8-11). O baixo consumo de frutas e hortaliças é tido como o maior fator para a baixa ingestão de micronutrientes, portanto, de desnutrição mundial. O consumo diário de 400 g de frutas e hortaliças ajuda a aliviar a deficiência de micronutrientes e a prevenir doenças crônicas associadas à alimentação e estilos de vida urbanos não saudáveis. O tamanho do agregado familiar mostra uma associação negativa com a procura de hortaliças e frutas. O sexo do chefe do agregado familiar é também determinante para o consumo de hortaliças e frutas. Famílias chefiadas por mulheres tendem a consumir mais hortaliças e frutas que às chefiadas por homens. A agricultura urbana e periurbana desempenha um papel importante no combate a insegurança alimentar e nutricional. Cerca de 15 a 20% da alimentação mundial provém da agricultura urbana e periurbana e 130 milhões de produtores urbanos vivem em África. A presente pesquisa pretende melhorar a alimentação das populações dos bairros periurbanos da cidade de Nampula contribuindo com a redução dos índices de desnutrição nesta cidade metadata Chiambiro Zano, Filipe mail UNSPECIFIED (2018) Agricultura urbana e peri-urbana: uma resposta alimentar a cresecente urbanização da cidade de Nampula. Doctoral thesis, Universidad Internacional Iberoamericana México.

Article Subjects > Biomedicine
Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Cerrado Inglés Ample epidemiological evidence suggests a strong correlation among diet, lifestyle factors and the onset and consolidation of dementia and Alzheimer’s disease (AD). It has been demonstrated that AD, diabetes, obesity, insulin resistance, and cardiovascular disease are strongly interconnected pathologies. Preventive strategies and nutritional interventions seem to be promising approaches to delay neurocognitive decline and reduce the risk of AD and other non-psychiatric co-morbidities. In this regard, healthy dietary patterns, characterized by high intake of plant-based foods, probiotics, antioxidants, soy beans, nuts, and omega-3 polyunsaturated fatty acids, and a low intake of saturated fats, animal-derived proteins, and refined sugars, have been shown to decrease the risk of neurocognitive impairments and eventually the onset of AD. Here we review the role of some nutrients and, in particular, of healthy dietary patterns, such as the Mediterranean diet and other emerging healthy diets, DASH (Dietary Approach to Stop Hypertension) and MIND (Mediterranean-DASH dietIntervention for Neurodegenerative Delay), for the maintenance of cognitive performance, focusing specifically on human studies. The beneficial effects associated with overall diet composition, rather than single nutrient supplementations, for the prevention or the delay of AD and dementia are discussed. metadata Pistollato, Francesca and Calderón Iglesias, Rubén and Ruiz Salces, Roberto and Aparicio-Obregón, Silvia and Crespo-Álvarez, Jorge and Dzul Lopez, Luis Alonso and Manna, Piera Pia and Giampieri, Francesca and Battino, Maurizio mail francesca.pistollato@uneatlantico.es, ruben.calderon@uneatlantico.es, roberto.ruiz@uneatlantico.es, silvia.aparicio@uneatlantico.es, jorge.crespo@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2018) Nutritional patterns associated with the maintenance of neurocognitive functions and the risk of dementia and Alzheimer’s disease: A focus on human studies. Pharmacological Research, 131. pp. 32-43. ISSN 10436618

Article Subjects > Nutrition Ibero-american International University > Research > Scientific Production Abierto Inglés This research is carried out as an alternative for the bakery industry when looking for new sources of vegetable flour to be used in the preparation of breads and cookies, because the wheat production in Ecuador is not enough. On the other hand, the cocoa industries in the country produce a high quantity of cocoa shells that are considered as agroindustrial waste, which come from the two main varieties of cocoa, Nacional Arriba and CCN51. That is why, as a product of the grinding of these husks, flour was obtained that was used for the production of breads and biscuits with different dosage percentages based on various bibliographical sources and the authors' own experiences. In the case of the breads, the dosage used was 10% and 20%, while for the cookies a dosage of 70% and 80% was applied. Both the breads and the cookies were evaluated fortheir sensorial quality, by means of untrained judges using a hedonic scale from 1 to 5. The results confirm a high sensory quality in the cookies compared with the sensory quality obtained in the breads. metadata El Salous, A and Pascual Barrera, Alina Eugenia mail UNSPECIFIED, alina.pascual@unini.edu.mx (2018) Sensorial Quality ofBreads and Cookies Prepared with Flour from The Shells of Two Varieties of Cocoain Ecuador. Italian Journal of Food Science. pp. 1-10.

2017

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Cerrado Inglés Dietary polyphenols have been recently proposed as activators of the AMP-activated protein kinase (AMPK) signaling pathway and this fact might explain the relationship between the consumption of polyphenol-rich foods and the slowdown of the progression of aging. In the present work, the effects of strawberry consumption were evaluated on biomarkers of oxidative damage and on aging-associated reductions in mitochondrial function and biogenesis for 8weeks in old rats. Strawberry supplementation increased antioxidant enzyme activities, mitochondrial biomass and functionality, and decreased intracellular ROS levels and biomarkers of protein, lipid and DNA damage (P<0.05). Furthermore, a significant (P<0.05) increase in the expression of the AMPK cascade genes, involved in mitochondrial biogenesis and antioxidant defences, was also detected after strawberry intake. These in vivo results were then verified in vitro on HepG2 cells, confirming the involvement of AMPK in the beneficial effects exerted by strawberry against aging progression. metadata Giampieri, Francesca and Alvarez-Suarez, Josè M. and Cordero, Mario D. and Gasparrini, Massimiliano and Forbes-Hernandez, Tamara Y. and Afrin, Sadia and Santos-Buelga, Celestino and González-Paramás, Ana M. and Astolfi, Paola and Rubini, Corrado and Zizzi, Antonio and Tulipani, Sara and Quiles, Josè L. and Mezzetti, Bruno and Battino, Maurizio mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, tamara.forbes@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2017) Strawberry consumption improves aging-associated impairments, mitochondrial biogenesis and functionality through the AMP-activated protein kinase signaling cascade. Food Chemistry, 234. pp. 464-471. ISSN 03088146

2016

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Inglés Accumulation of proteinaceous amyloid β plaques and tau oligomers may occur several years before the onset of Alzheimer disease (AD). Under normal circumstances, misfolded proteins get cleared by proteasome degradation, autophagy, and the recently discovered brain glymphatic system, an astroglial-mediated interstitial fluid bulk flow. It has been shown that the activity of the glymphatic system is higher during sleep and disengaged or low during wakefulness. As a consequence, poor sleep quality, which is associated with dementia, might negatively affect glymphatic system activity, thus contributing to amyloid accumulation. The diet is another important factor to consider in the regulation of this complex network. Diets characterized by high intakes of refined sugars, salt, animal-derived proteins and fats and by low intakes of fruit and vegetables are associated with a higher risk of AD and can perturb the circadian modulation of cortisol secretion, which is associated with poor sleep quality. For this reason, diets and nutritional interventions aimed at restoring cortisol concentrations may ease sleep disorders and may facilitate brain clearance, consequentially reducing the risk of cognitive impairment and dementia. Here, we describe the associations that exist between sleep, cortisol regulation, and diet and their possible implications for the risk of cognitive impairment and AD. metadata Pistollato, Francesca and Sumalla Cano, Sandra and Elío Pascual, Iñaki and Masias Vergara, Manuel and Giampieri, Francesca and Battino, Maurizio mail francesca.pistollato@uneatlantico.es, sandra.sumalla@uneatlantico.es, inaki.elio@uneatlantico.es, manuel.masias@uneatlantico.es, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es (2016) Associations between Sleep, Cortisol Regulation, and Diet: Possible Implications for the Risk of Alzheimer Disease. Advances in Nutrition: An International Review Journal, 7 (4). pp. 679-689. ISSN 2156-5376

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Inglés We describe the biological effects of a polyphenol-rich strawberry extract (PRSE), obtained from the “Alba” variety, on the highly aggressive and invasive basal-like breast cancer cell line A17. Dose-response and time-course experiments showed that PRSE is able to decrease the cellular viability of A17 cells in a time- and dose-dependent manner. PRSE effect on cell survival was investigated in other tumor and normal cell lines of both mouse and human origin, demonstrating that PRSE is more active against breast cancer cells. Cytofluorimetric analysis of A17 cells demonstrated that sub-lethal doses of PRSE reduce the number of cells in S phase, inducing the accumulation of cells in G1 phase of cell cycle. In addition, the migration of A17 cells was studied monitoring the ability of PRSE to inhibit cellular mobility. Gene expression analysis revealed the modulation of 12 genes playing different roles in the cellular migration, adhesion and invasion processes. Finally, in vivo experiments showed the growth inhibition of A17 cells orthotopically transplanted into FVB syngeneic mice fed with PRSE. Overall, we demonstrated that PRSE exerts important biological activities against a highly invasive breast cancer cell line both in vitro and in vivo suggesting the strawberry extracts as preventive/curative food strategy. metadata Amatori, Stefano and Mazzoni, Luca and Alvarez-Suarez, José M. and Giampieri, Francesca and Gasparrini, Massimiliano and Forbes-Hernandez, Tamara Y. and Afrin, Sadia and Errico Provenzano, Alfredo and Persico, Giuseppe and Mezzetti, Bruno and Amici, Augusto and Fanelli, Mirco and Battino, Maurizio mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, tamara.forbes@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2016) Polyphenol-rich strawberry extract (PRSE) shows in vitro and in vivo biological activity against invasive breast cancer cells. Scientific Reports, 6 (1). ISSN 2045-2322

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Inglés It has been hypothesized that alterations in the composition of the gut microbiota might be associated with the onset of certain human pathologies, such as Alzheimer disease, a neurodegenerative syndrome associated with cerebral accumulation of amyloid-β fibrils. It has been shown that bacteria populating the gut microbiota can release significant amounts of amyloids and lipopolysaccharides, which might play a role in the modulation of signaling pathways and the production of proinflammatory cytokines related to the pathogenesis of Alzheimer disease. Additionally, nutrients have been shown to affect the composition of the gut microbiota as well as the formation and aggregation of cerebral amyloid-β. This suggests that modulating the gut microbiome and amyloidogenesis through specific nutritional interventions might prove to be an effective strategy to prevent or reduce the risk of Alzheimer disease. This review examines the possible role of the gut in the dissemination of amyloids, the role of the gut microbiota in the regulation of the gut–brain axis, the potential amyloidogenic properties of gut bacteria, and the possible impact of nutrients on modulation of microbiota composition and amyloid formation in relation to the pathogenesis of Alzheimer disease. metadata Pistollato, Francesca and Sumalla Cano, Sandra and Elío Pascual, Iñaki and Masias Vergara, Manuel and Giampieri, Francesca and Battino, Maurizio mail francesca.pitollato@uneatlantico.es, sandra.sumalla@uneatlantico.es, inaki.elio@uneatlantico.es, manuel.masias@uneatlantico.es, franscesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es (2016) Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease. Nutrition Reviews, 74 (10). pp. 624-634. ISSN 0029-6643

Other Subjects > Nutrition Ibero-american International University > Research > Projects I+D+I Cerrado Español El objetivo de PEPANPI es el de poder ofrecer el primer servicio de mejora avanzada de productos alimentarios a partir del cual se puedan mejorar cuatro aspectos fundamentales del alimento: calidad nutricional, organoléptica, sanitaria y comercial. En particular, se aborda el desarrollo de alimentos de segunda generación en el ámbito de harinas y derivados. Para ello la empresa solicita la colaboración de la Universidad Europea del Atlántico dada su especialización en los ámbitos de la agroalimentación y de la nutrición humana. Objetivo del Proyecto: Desarrollo de alimentos de segunda generación en el ámbito de harinas y derivados. Financiación: Este proyecto ha sido cofinanciado por la Sociedad de Desarrollo Regional de Cantabria (SODERCAN) y el el Programa Operativo FEDER de Cantabria en el marco del programa denominado I+C= +C 2016 (Investigación + Conocimiento= +Cantabria) que tiene por objetivo el fortalecimiento del tejido industrial de la región. Inicio: 18/11/2016 Fin: 17/11/2018 metadata Centro de Investigación y Tecnología Industrial de Cantabria, CITICAN mail citican@devnull.uneatlantico.es (2016) Servicio para el diseño de alimentos funcionales de segunda generación: aplicaciones a la industria agroalimentaria. Repositorio de la Universidad. (Unpublished)

2015

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Cerrado Inglés Oxidative stress is implicated in several infectious diseases. In this regard, lipopolysaccharide (LPS), an endotoxic component, induces mitochondrial dysfunction and oxidative stress in several pathological events such as periodontal disease or sepsis. In our experiments, LPS-treated fibroblasts provoked increased oxidative stress, mitochondrial dysfunction, reduced oxygen consumption and mitochondrial biogenesis. After comparing coenzyme Q10 (CoQ10) and N-acetylcysteine (NAC), we observed a more significant protection of CoQ10 than of NAC, which was comparable with other lipophilic and hydrophilic antioxidants such as vitamin E or BHA respectively. CoQ10 improved mitochondrial biogenesis by activating PGC-1α and TFAM. This lipophilic antioxidant protection was observed in mice after LPS injection. These results show that mitochondria-targeted lipophilic antioxidants could be a possible specific therapeutic strategy in pharmacology in the treatment of infectious diseases and their complications. metadata Bullón, Pedro and Román-Malo, Lourdes and Marín-Aguilar, Fabiola and Alvarez-Suarez, José Miguel and Giampieri, Francesca and Battino, Maurizio and Cordero, Mario D. mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, josemanuel.alvarez@unini.edu.mx, UNSPECIFIED, maurizio.battino@uneatlantico.es, UNSPECIFIED (2015) Lipophilic antioxidants prevent lipopolysaccharide-induced mitochondrial dysfunction through mitochondrial biogenesis improvement. Pharmacological Research, 91. pp. 1-8. ISSN 10436618

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Inglés Environmental and lifestyle factors are known to play an important role during gestation, determining newborns' health status and influencing their risk of being subject to certain noncommunicable diseases later in life. In particular, maternal nutritional patterns characterized by a low intake of plant-derived foods could increase the risk of gestation-related issues, such as preeclampsia and pregravid obesity, increase genotoxicant susceptibility, and contribute to the onset of pediatric diseases. In particular, the risk of pediatric wheeze, diabetes, neural tube defects, orofacial clefts, and some pediatric tumors seems to be reduced by maternal intake of adequate amounts of vegetables, fruits, and selected antioxidants. Nevertheless, plant-based diets, like any other diet, if improperly balanced, could be deficient in some specific nutrients that are particularly relevant during gestation, such as n–3 (ω-3) fatty acids, vitamin B-12, iron, zinc, and iodine, possibly affecting the offspring's health state. Here we review the scientific literature in this field, focusing specifically on observational studies in humans, and highlight protective effects elicited by maternal diets enriched in plant-derived foods and possible issues related to maternal plant-based diets. metadata Pistollato, Francesca and Sumalla Cano, Sandra and Elio Pascual, Iñaki and Masias Vergara, Manuel and Giampieri, Francesca and Battino, Maurizio mail francesca.pistollato@uneatlantico.es, sandra.sumalla@uneatlantico.es, inaki.elio@uneatlantico.es, manuel.masias@uneatlantico.es, UNSPECIFIED, maurizio.battino@uneatlantico.es (2015) Plant-Based and Plant-Rich Diet Patterns during Gestation: Beneficial Effects and Possible Shortcomings. Advances in Nutrition, 6 (5). pp. 581-591. ISSN 2161-8313

Article Subjects > Biomedicine
Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Cerrado Inglés In the last decade, specific dietary patterns, mainly characterized by high consumption of vegetables and fruits, have been proven beneficial for the prevention of both metabolic syndrome (MetS)-related dysfunctions and neurodegenerative disorders, such as Alzheimer’s disease (AD). Nowadays, neuroimaging readouts can be used to diagnose AD, investigate MetS effects on brain functionality and anatomy, and assess the effects of dietary supplementations and nutritional patterns in relation to neurodegeneration and AD-related features. Here we review scientific literature describing the use of the most recent neuroimaging techniques to detect AD- and MetS-related brain features, and also to investigate associations between consolidated dietary patterns or nutritional interventions and AD, specifically focusing on observational and intervention studies in humans. metadata Pistollato, Francesca and Sumalla Cano, Sandra and Elío Pascual, Iñaki and Masías Vergara, Manuel and Giampieri, Francesca and Battino, Maurizio mail francesca.pistollato@uneatlantico.es, sandra.sumalla@uneatlantico.es, inaki.elio@uneatlantico.es, manuel.masias@uneatlantico.es, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es (2015) The Use of Neuroimaging to Assess Associations Among Diet, Nutrients, Metabolic Syndrome, and Alzheimer’s Disease. Journal of Alzheimer's Disease, 48 (2). pp. 303-318. ISSN 13872877

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Cerrado Inglés Berries are a relevant source of micronutrients and nonessential phytochemicals, such as polyphenol compounds, that play a synergistic and cumulative role in human health promotion. Several systematic analyses showed that berry phenolics are able to detoxify reactive oxygen and nitrogen species, blocking their production, to intervene in the cell cycle, participating in the transduction and expression of genes involved in apoptosis, and to repair oxidative DNA damage. As a consequence, the improvement of the nutritional quality of berries has become a new quality target of breeding and biotechnological strategies, to control or to increase the content of specific health-related compounds in fruits. This work reviews, on the basis of the in vitro and in vivo evidence, the main berries' phytochemical compounds and their possible mechanisms of action on pathways involved in several type of diseases, with particular attention to cancer, inflammation, neurodegeneration, diabetes and cardiovascular diseases. © 2015 Society of Chemical Industry metadata Mazzoni, Luca and Perez-Lopez, Patricia and Giampieri, Francesca and Alvarez-Suarez, José M. and Gasparrini, Massimiliano and Forbes-Hernandez, Tamara Y. and Quiles, José L. and Mezzetti, Bruno and Battino, Maurizio mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, tamara.forbes@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2015) The genetic aspects of berries: from field to health. Journal of the Science of Food and Agriculture, 96 (2). pp. 365-371. ISSN 00225142

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Cerrado Inglés In the last decades cancer has been considered as an epigenetic dysfunction, given the profound role of diet and lifestyle in cancer prevention and the determination of cancer risk. A plethora of recent publications have addressed the specific role of several environmental factors, such as nutritional habits, behavior, stress and toxins in the regulation of the physiological and cancer epigenome. In particular, plant-derived bioactive nutrients have been seen to positively affect normal cell growth, proliferation and differentiation and also to revert cancer related epigenetic dysfunctions, reducing tumorigenesis, preventing metastasis and/or increasing chemo and radiotherapy efficacy. Moreover, virtually all cancer types are characterized by the presence of cancer stem cell (CSC) subpopulations, residing in specific hypoxic and acidic microenvironments, or niches, and these cells are currently considered responsible for tumor resistance to therapy and tumor relapse. Modern anti-cancer strategies should be designed to selectively target CSCs and modulate the hypoxic and acidic tumor microenvironment, and, to this end, natural bioactive components seem to play a role. This review aims to discuss the effects elicited by plant-derived bioactive nutrients in the regulation of CSC self-renewal, cancer metabolism and tumor microenvironment. metadata Pistollato, Francesca and Giampieri, Francesca and Battino, Maurizio mail francesa.pistollato@uneatlantico.es, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es (2015) The use of plant-derived bioactive compounds to target cancer stem cells and modulate tumor microenvironment. Food and Chemical Toxicology, 75. pp. 58-70. ISSN 02786915

2014

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Inglés Strawberry bioactive compounds are widely known to be powerful antioxidants. In this study, the antioxidant and anti-aging activities of a polyphenol-rich strawberry extract were evaluated using human dermal fibroblasts exposed to H2O2. Firstly, the phenol and flavonoid contents of strawberry extract were studied, as well as the antioxidant capacity. HPLC-DAD analysis was performed to determine the vitamin C and β-carotene concentration, while HPLC-DAD/ESI-MS analysis was used for anthocyanin identification. Strawberry extract presented a high antioxidant capacity, and a relevant concentration of vitamins and phenolics. Pelargonidin- and cyanidin-glycosides were the most representative anthocyanin components of the fruits. Fibroblasts incubated with strawberry extract and stressed with H2O2 showed an increase in cell viability, a smaller intracellular amount of ROS, and a reduction of membrane lipid peroxidation and DNA damage. Strawberry extract was also able to improve mitochondrial functionality, increasing the basal respiration of mitochondria and to promote a regenerative capacity of cells after exposure to pro-oxidant stimuli. These findings confirm that strawberries possess antioxidant properties and provide new insights into the beneficial role of strawberry bioactive compounds on protecting skin from oxidative stress and aging. metadata Giampieri, Francesca and Alvarez-Suarez, José and Mazzoni, Luca and Forbes-Hernandez, Tamara Y. and Gasparrini, Massimiliano and Gonzàlez-Paramàs, Ana and Santos-Buelga, Celestino and Quiles, José and Bompadre, Stefano and Mezzetti, Bruno and Battino, Maurizio mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, tamara.forbes@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2014) Polyphenol-Rich Strawberry Extract Protects Human Dermal Fibroblasts against Hydrogen Peroxide Oxidative Damage and Improves Mitochondrial Functionality. Molecules, 19 (6). pp. 7798-7816. ISSN 1420-3049