Biomedicina
A
Adherence to the Mediterranean Diet Is Inversely Associated with the Prevalence of Metabolic Syndrome in Older People from the North of Spain.
Advancements in Dentistry with Artificial Intelligence: Current Clinical Applications and Future Perspectives.
Amyloid β-but not Tau-induced neurotoxicity is suppressed by Manuka honey via HSP-16.2 and SKN-1/Nrf2 pathways in an in vivo model of Alzheimer's disease.
Anti-inflammatory effect of strawberry extract against LPS-induced stress in RAW 264.7 macrophages.
Antimicrobial Resistance Determinants in Genomes and Plasmids from Acinetobacter baumannii Clinical Isolates.
Antimicrobial resistant enteric bacteria are widely distributed among environmental water sources in Dhaka, Bangladesh.
Análisis Del Recurso Humano Disponible y Las Cargas De Trabajo En El Laboratorio Clínico del Hospital Los Chiles, Costa Rica, durante el 2015 al 2019.
Análisis de la gestión actual del programa de pacientes en condición de Hemofilia y Enfermedad de VonWillebrand (EVW) de la IPS Clínica Oasis, en la región Nororiente, Costa Norte y Centro de Colombia durante el año 2020 y primer trimestre 2021.
Análisis de la influencia de programas de salud pública, variables socioeconómicas y sanitarias de Chile, sobre las tasas de mortalidad por neumonía adquirida en la comunidad, periodo 1985-2021.
Análisis de las acciones en promoción de la salud, del profesional de enfermería que labora en el primer nivel de atención del sistema de salud del seguro social campesino, Azogues-Ecuador, enero-abril 2022.
Análisis del Ecoturismo en Punta Cana, Republica Dominicana.
Are by-products from beeswax recycling process a new promising source of bioactive compounds with biomedical properties?
A Comparative Analysis of a Self-Reported Adverse Events Analysis after Receiving One of the Available SARS-CoV-2 Vaccine Schemes in Ecuador.
A Comparison of the Clinical Characteristics of Short-, Mid-, and Long-Term Mortality in Patients Attended by the Emergency Medical Services: An Observational Study.
A Comprehensive Review of Recent Advances in Artificial Intelligence for Dentistry E-Health.
A Computerized Analysis with Machine Learning Techniques for the Diagnosis of Parkinson’s Disease: Past Studies and Future Perspectives.
An Effective Method for Lung Cancer Diagnosis from CT Scan Using Deep Learning-Based Support Vector Network.
A Hybrid Convolutional Neural Network Model for Diagnosis of COVID-19 Using Chest X-ray Images.
A Pilot Study of the Photoprotective Effects of Strawberry-Based Cosmetic Formulations on Human Dermal Fibroblasts.
A Systematic Review and Meta-Analysis of Premenstrual Syndrome with Special Emphasis on Herbal Medicine and Nutritional Supplements.
A lightweight deep learning approach for COVID-19 detection using X-ray images with edge federation.
B
Barriers to and facilitators of adherence to pelvic floor muscle exercises and vaginal dilator use among gynecologic cancer patients: a qualitative study.
Biodisponibilidad de fósforo en alimentos y su efecto en la enfermedad renal crónica.
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Calidad asistencial percibida y satisfacción de las personas mayores atendidas en el servicio de urgencias en Sonora México.
Calidad de la atención del personal de enfermería que labora en el Centro Obstétrico del Hospital General Docente de Calderón, Quito - Ecuador durante el periodo 2022.
Calidad de vida y determinantes sociales de pacientes mexicanas con cáncer de mama, 2023.
Caracterización de eventos adversos y propuesta de plan de acción para la mejora continua de la calidad asistencial en el hospital General Quevedo periodo 2021.
Caracterização da violência autoprovocada em Itaipulândia/Paraná- Brasil, no período de 2013 a 2019.
Chronotype and Cancer: Emerging Relation Between Chrononutrition and Oncology from Human Studies.
Clasificación de riesgos en el manejo y transporte de cargas para la prevención de los problemas osteomusculares en los trabajadores de exportadora de cacao Verapaz.
Clinical Taste Perception Test for Patients With End-Stage Kidney Disease on Dialysis.
Clinical epidemiology of dengue and COVID-19 co-infection among the residents in Dhaka, Bangladesh, 2021-2023: A cross-sectional study.
Clinical phenotypes and short-term outcomes based on prehospital point-of-care testing and on-scene vital signs.
Clinical phenotypes and short-term outcomes based on prehospital point-of-care testing and on-scene vital signs.
Conflictos de intereses de los médicos de Chile con la industria ligada a la salud.
Consortium Framework Using Blockchain for Asthma Healthcare in Pandemics.
Correction to: Systematic Review of Telemedicine and eHealth Systems Applied to Vascular Surgery.
Correction: Prediction of leukemia peptides using convolutional neural network and protein compositions.
Corrigendum to “Dietary supplementation of Bacillus velezensis improves Vibrio anguillarum clearance in European sea bass by activating essential innate immune mechanisms” [Fish Shellfish Immunol. 124 (2022) 244–253].
Criterios Éticos De Hospitalización En Personas Adultas Mayores En El Contexto De La Pandemia (COVID – 19) En Un Hospital De Quito – Ecuador, Desde Marzo Del 2020 A Enero Del 2021.
Cuidado informal en personas mayores con demencia, rol del hombre cuidador.
Cytotoxicity and Antimicrobial Resistance of Aeromonas Strains Isolated from Fresh Produce and Irrigation Water.
D
Desarrollo de competencias en Salud Visual para rehabilitación protésica de pacientes con anoftálmia.
Desarrollo de una galleta con harinas de haba (Vicia faba), chapulines (Sphenarium purpurascens charpentier) y totomoxtle de maíz (Zea mayz) y evaluación sensorial en niños de la Primaria Enrique C. Rebsamen de Oriental Puebla.
Design and Development of Smart Weight Measurement, Lateral Turning and Transfer Bedding for Unconscious Patients in Pandemics.
Determinación y comparación de distintas medidas antropométricas y las ecuaciones de estimación de peso en pacientes del Hospital General en Zacapu Michoacán: Propuesta de implementación de la fórmula de estimación de peso al personal de salud para que la empleen en su práctica clínica.
DiabSense: early diagnosis of non-insulin-dependent diabetes mellitus using smartphone-based human activity recognition and diabetic retinopathy analysis with Graph Neural Network.
Diagnosing epileptic seizures using combined features from independent components and prediction probability from EEG data.
Dietary counseling, meal patterns, and diet quality in patients with type 2 diabetes mellitus with/without chronic kidney disease.
Diseño de material didáctico como herramienta para mejorar la comprensión del lengua en niños de inicial 2 de la unidad educativa “Chone”diseño de material didáctico como herramienta para mejorar la comprensión del lengua en niños de inicial 2 de la unidad educativa “Chone”.
Diseño de un plan estratégico para la prevención de sobrepeso y obesidad infantil en Quevedo-Ecuador.
Diseño de un programa educativo para fomentar el autocuidado en pacientes con Diabetes Mellitus en el Centro de Salud Cevallos Provincia de Tungurahua-Ecuador.
Diseño de un protocolo de manejo perioperatorio en cirugías abdominales para pacientes del servicio de cirugía del hospital Alianza, Quito-Ecuador, 2021.
Diseño del programa de vigilancia epidemiológica para la prevención de síndromes dolorosos asociados a riesgos ergonómicos en la empresa Agrojaba S.A.S en el municipio de Palmira, Colombia.
Diseño e implementación de un modelo de atención de enfermería basado en modelo de sistemas de Betty Neuman para pacientes dializados y su familia.
E
Editorial: Host-bacteria interactions in fish pathogens.
Educational interventions on breast cancer in men and women: a necessity in primary healthcare.
Efecto de la suplementación parenteral con ácidos grasos omega-3 sobre marcadores de pronóstico clínico médicos, nutricionales y bioquímicos en sujetos con estado crítico.
Efectos del Kéfir Moderno sobre el Peso, Estatura, Gasto Energético y Trastornos Intestinales y Respiratorios Asociados en la Parálisis Cerebral Hipertónica.
Efectos del ejercicio físico sobre marcadores antropométricos, fuerza muscular y presión arterial en pacientes con hemodiálisis: una revisión narrativa.
Effects of caloric restriction on immunosurveillance, microbiota and cancer cell phenotype: Possible implications for cancer treatment.
Effects of phytochemicals on thyroid function and their possible role in thyroid disease.
El Aprendizaje colaborativo online como herramienta didáctica en Espacios de Enseñanza de Educación Superior (EEES) en los estudiantes de Postgrado de Medicina Interna.
Elaboración de propuesta de mejora mediante el uso de las Tecnologías de Información y Comunicación como Recurso Didáctico en el Proceso de Aprendizaje de Estudiantes Externos de Medicina de la Universidad de las Américas en el año 2021 del Hospital Militar de Quito en el servicio de columna vertebral – traumatología.
Empowering Lower Limb Disorder Identification through PoseNet and Artificial Intelligence.
Enhanced detection of diabetes mellitus using novel ensemble feature engineering approach and machine learning model.
Enhanced interpretable thyroid disease diagnosis by leveraging synthetic oversampling and machine learning models.
Equilibrio Ocupacional y percepción de salud en la “nueva normalidad”: Relatos postcuarentena de personas mayores en situación de discapacidad de un Centro Comunitario de Rehabilitación.
Estado Nutricional, Hábitos Alimentarios y El Consumo De Alimentos Desencadenantes De Síntomas Gastrointestinales En Pacientes De 30 a 50 Años Con Síndrome De Intestino Irritable Que Asisten a La Unidad De Especialidad Médica UNEME SORID, En La Ciudad De Chetumal, Quintana Roo – México, Durante El Año 2022.
Estrategias motivacionales para el personal de enfermería que labora en áreas críticas del Hospital Verdi Cevallos Balda.Noviembre2021-Enero2022.
Evaluación de la atención en Salud, diseño documentación y medición de procesos en los Servicios auxiliares de diagnostico del Centro de Salud A San Lorenzo.
Evaluación de la calidad de servicios de atención al paciente en el consultorio privado médico-estético MEDICINESTHETIC, en la ciudad de Guayaquil durante el periodo 2020-2021.
Evaluación de la calidad de servicios de salud en el departamento médico de la empresa privada sálica del ecuador, ubicado en la parroquia Posorja, en el periodo de agosto y septiembre de 2021.
Evaluación de la calidad en los procesos del servicio de Radiología e Imagen en un Hospital Regional, con la finalidad de certificación.
Evaluación de los conocimientos de salud bucal y estado bucodental en adolescentes escolares de edades entre 15 y 18 años del Colegio Nehemías, en el municipio de Masatepe, Masaya, Nicaragua. Segundo semestre 2021.
Evaluación de los riesgos biológicos y ergonómicos en la salud del personal de enfermería encargado de la atención de pacientes de una unidad de hemodiálisis en la ciudad de Guayaquil, marzo 2020 – agosto 2021.
Evaluation du plateau technique médical de néonatologie en Afrique subsaharienne : cas du Sénégal.
Evaluation of the Analgesic Efficacy of a Bioelectronic Device in Non-Specific Chronic Low Back Pain with Neuropathic Component. A Randomized Trial.
Evolving epidemiology, clinical features, and genotyping of dengue outbreaks in Bangladesh, 2000–2024: a systematic review.
Exploring factors influencing the severity of pregnancy anemia in India: a study using proportional odds model.
F
Factores de la intención de revisita de los pacientes del sistema de atención primaria de la salud de la ciudad de Rosario, Argentina mediante modelamiento con ecuaciones estructurales por el método de mínimos cuadrados parciales (SEM PLS).
Factores de riesgo de enfermedades crónicas no transmisibles en pacientes usuarios de UCSF la presita versus personal de salud que labora en UCSF la presita de la ciudad de San Miguel.
Factores de riesgo para accidente cerebrovascular en adultos jóvenes.
Factores determinantes de la inasistencia de las embarazadas a consulta odontológica en el Subcentro de Salud Llacao, Cuenca - Ecuador.
Factores determinantes en el uso de métodos anticonceptivos en la población de 15 a 19 años en la delegación Cuauhtémoc, Ciudad de México.
Fatores Influenciadores na Escolha do Tipo de Parto de Gestantes da Estratégia Saúde da Família Caramuru, no Município de Itaipulândia-Pr, no Ano de 2021.
Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action.
Funcionalidad motriz, estado nutricional e índices antropométricos de riesgo cardiometabólico en adolescentes chilenos de 12 a 15 años.
Fundus image classification using feature concatenation for early diagnosis of retinal disease.
G
Genetic Resistance Determinants in Clinical Acinetobacter pittii Genomes.
Gestión adecuada de los residuos hospitalarios en Livet Medical Center, Guayaquil-Ecuador durante el período de abril a junio de 2021.
Guía Didáctica para el proceso de enseñanza aprendizaje en la carrera de medicina, asignatura de pediatría de la Universidad Estatal de Guayaquil, Cantón Guayaquil, Provincia del Guayas, Ecuador.
I
Impacto del perfil epidemiológico, sociocultural y económico sobre el crecimiento, morbilidad y mortalidad de la infección por SARS CoV2, en el Noreste de México.
Implementación de herramienta digital de evaluación del riesgo obstétrico en Veracruz, México en el periodo de julio a octubre del año 2021.
Importancia de las Visitas domiciliarias en prevención de úlceras por presión en adultos mayores.
Influencia de las medidas de bioseguridad implementadas por la pandemia COVID19 en la disminución de infecciones nosocomiales en el área de hospitalización de Pediatría en el Hospital General Guasmo Sur, en el período 2019-2020.
Ingesta de nuez (Juglans regia), para modificar el porcentaje de grasa corporal y el índice de masa corporal en médicos especialistas que realizan trabajo nocturno.
Isoflavones Effects on Vascular and Endothelial Outcomes: How Is the Gut Microbiota Involved?
K
Kinetics of the invasion of a non-phagocytic fish cell line, RTG-2 by Yersinia ruckeri serotype O1 biotype 1.
L
La participación ocupacional significativa del adulto mayor en el contexto institucional.
Lipid Accumulation in HepG2 Cells Is Attenuated by Strawberry Extract through AMPK Activation.
M
Molecular Interactions between Dietary Lipids and Bone Tissue during Aging.
Molecular epidemiology, transmission and clinical features of 2022‐mpox outbreak: A systematic review.
Multidrug resistance pattern and molecular epidemiology of pathogens among children with diarrhea in Bangladesh, 2019–2021.
Multipath Routing in Wireless Body Area Sensor Network for Healthcare Monitoring.
N
Nerve Root Compression Analysis to Find Lumbar Spine Stenosis on MRI Using CNN.
Nivel de Conocimiento y Actitudes Sobre el COVID-19 en Personal de Enfermería de un Centro de Salud Público de Nagua, República Dominicana, 2021.
Nivel de habilidades para realizar el trabajo de investigación científica y su relación con los conocimientos en metodología de la investigación y cultura estadística para la propuesta de un programa estratégico en internos de nutrición y dietética de la Universidad Técnica de Manabí, Ecuador 2021.
Nutritional patterns associated with the maintenance of neurocognitive functions and the risk of dementia and Alzheimer’s disease: A focus on human studies.
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Percepción de la satisfacción de los usuarios del Hospital de Niños Dr. Roberto Gilbert Elizalde en relación a la atención recibida en el servicio de Hospitalización. Guayaquil 2021.
Percepción del cuidado asistencial en personas con demencia, por parte del personal de enfermería, en Costa Rica en el año 2021.
Perfil paliativo en adultos mayores con demencia avanzada.
Performance of the 4C and SEIMC scoring systems in predicting mortality from onset to current COVID-19 pandemic in emergency departments.
Performance of the 4C and SEIMC scoring systems in predicting mortality from onset to current COVID-19 pandemic in emergency departments.
Phage Therapy as a Focused Management Strategy in Aquaculture.
Plan de Gestión Integrada: Medio ambiente, Calidad y Prevención, para los Laboratorios de Química y Biología de la Facultad Multidisciplinaria Oriental (FMO) de la Universidad de El Salvador.
Plan estratégico de Marketing digital para una Unidad de Rehabilitación Cardíaca.
Plan estratégico preventivo para reducir el estrés laboral en el personal de enfermería del servicio de Neurología del Hospital de Especialidades Carlos Andrade Marín de la ciudad de Quito en el periodo de Mayo – Noviembre 2021.
Prediction of leukemia peptides using convolutional neural network and protein compositions.
Prehospital acute life-threatening cardiovascular disease in elderly: an observational, prospective, multicentre, ambulance-based cohort study.
Prehospital qSOFA, mSOFA, and NEWS2 performance for sepsis prediction: A prospective, multi-center, cohort study.
Prevalence and genetic diversity of rotavirus in Bangladesh during pre-vaccination period, 1973-2023: a meta-analysis.
Prevalence and impact of long COVID-19 among patients with diabetes and cardiovascular diseases in Bangladesh.
Prevalencia de la anemia ferropénica y factores asociados en niños menores de 3 años atendidos en el Centro de Salud Tipo B de Nobol en el año 2019.
Prickly pear fruits from "Opuntia ficus-indica" varieties as a source of potential bioactive compounds in the Mediterranean diet.
Programa para la prevención de intoxicaciones en niños en edad escolar (6-12 años) en la gran área metropolitana (GAM) de Costa Rica durante el año 2022-2023.
Propuesta de modelo de atencion para reduccion de estancia hospitalaria, complicaciones, mortalidad y costos en pacientes con fractura de cadera, en Hospital General de El Salvador, 2012-2020.
Propuesta de reestructuración de la Sección Microbiología del Servicio de Laboratorio del Hospital Regional Concepción Dr. Miguel Belascuain de la ciudad de Concepción, Tucumán, Argentina, 2021.
Propuesta de un manual de especificaciones para promover el agilismo dentro de los procesos del departamento técnico de la empresa CORP-GTB CIA. LTDA.
Protective Effect of Strawberry Extract against Inflammatory Stress Induced in Human Dermal Fibroblasts.
Pupilometer efficacy in monitoring anxiety in undergraduate medical students during high-fidelity clinical simulation.
R
Relación entre el apego a la dieta y la educación nutricional en pacientes con diálisis del Hospital General de Atlacomulco y el Hospital General de San Felipe del Progreso, Estado de México.
Resveratrol and vascular health: evidence from clinical studies and mechanisms of actions related to its metabolites produced by gut microbiota.
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SARSMutOnto: An Ontology for SARS-CoV-2 Lineages and Mutations.
Satisfacción de los usuarios hospitalizados en el Instituto de Neurociencias de la ciudad de Guayaquil, Ecuador en los años 2019 y 2020.
Satisfacción laboral del personal de enfermería sobre el cuidado de pacientes comprometidos con SARS-CoV-2 en el periodo Marzo-Diciembre 2020 en La Pampa Argentina.
Satisfacción laboral en médicos rurales del primer nivel de atención de salud del Ministerio de Salud Pública, Ecuador, en el periodo febrero – marzo 2022.
Satisfacción laboral y desempeño laboral en los profesionales de Enfermería que laboran en el área Tocoquirúrgico del Hospital Teodoro Maldonado Carbo de Guayaquil, durante mayo – julio del 2021.
Severity of protein-energy wasting and obesity are independently related with poor quality of life in peritoneal dialysis patients.
Severity of protein-energy wasting and obesity are independently related with poor quality of life in peritoneal dialysis patients.
Side effects associated with homogenous and heterogenous doses of Oxford–AstraZeneca vaccine among adults in Bangladesh: an observational study.
Side effects associated with homogenous and heterogenous doses of Oxford–AstraZeneca vaccine among adults in Bangladesh: an observational study.
Sistema de vigilancia epidemiológica para CO-VID-19 y su aplicación en el cantón de Parrita, Puntarenas, Costa Rica.
Smart Physiotherapy: Advancing Arm-Based Exercise Classification with PoseNet and Ensemble Models.
StackIL10: A stacking ensemble model for the improved prediction of IL-10 inducing peptides.
Strawberry (cv. Romina) Methanolic Extract and Anthocyanin-Enriched Fraction Improve Lipid Profile and Antioxidant Status in HepG2 Cells.
Strawberry consumption alleviates doxorubicin-induced toxicity by suppressing oxidative stress.
Strawberry extracts efficiently counteract inflammatory stress induced by the endotoxin lipopolysaccharide in Human Dermal Fibroblast.
Strawberry-Based Cosmetic Formulations Protect Human Dermal Fibroblasts against UVA-Induced Damage.
Systematic Review of Machine Learning applied to the Prediction of Obesity and Overweight.
Systematic Review of Telemedicine and eHealth Systems Applied to Vascular Surgery.
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The Application of Digital Technologies and Artificial Intelligence in Healthcare: An Overview on Nutrition Assessment.
The Molecular Basis of Different Approaches for the Study of Cancer Stem Cells and the Advantages and Disadvantages of a Three-Dimensional Culture.
The Molecular Weaponry Produced by the Bacterium Hafnia alvei in Foods.
Targeting Glioblastoma with the Use of Phytocompounds and Nanoparticles.
The Use of Neuroimaging to Assess Associations Among Diet, Nutrients, Metabolic Syndrome, and Alzheimer’s Disease.
The healthy effects of strawberry bioactive compounds on molecular pathways related to chronic diseases.
The use of natural compounds for the targeting and chemoprevention of ovarian cancer.
The world’s deadliest outbreak during the COVID-19 Pandemic: A proposed analytical approach to estimate Daily Excess mortality rates in Ecuador.
U
Upholding or Breaking the Law of Superposition in Pharmacokinetics.
V
Ventilator pressure prediction employing voting regressor with time series data of patient breaths.
Virtual histopathology methods in medical imaging - a systematic review.
Voxel Extraction and Multiclass Classification of Identified Brain Regions across Various Stages of Alzheimer’s Disease Using Machine Learning Approaches.
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White Blood Cell Classification Using Texture and RGB Features of Oversampled Microscopic Images.
<a class="ep_document_link" href="/17569/1/Food%20Frontiers%20-%202025%20-%20Romero%E2%80%90Marquez%20-%20Olive%20Leaf%20Extracts%20With%20High%20%20Medium%20%20or%20Low%20Bioactive%20Compounds%20Content.pdf"><img class="ep_doc_icon" alt="[img]" src="/style/images/fileicons/text.png" border="0"/></a>
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Alzheimer's disease (AD) involves β-amyloid plaques and tau hyperphosphorylation, driven by oxidative stress and neuroinflammation. Cyclooxygenase-2 (COX-2) and acetylcholinesterase (AChE) activities exacerbate AD pathology. Olive leaf (OL) extracts, rich in bioactive compounds, offer potential therapeutic benefits. This study aimed to assess the anti-inflammatory, anti-cholinergic, and antioxidant effects of three OL extracts (low, mid, and high bioactive content) in vitro and their protective effects against AD-related proteinopathies in Caenorhabditis elegans models. OL extracts were characterized for phenolic composition, AChE and COX-2 inhibition, as well as antioxidant capacity. Their effects on intracellular and mitochondrial reactive oxygen species (ROS) were tested in C. elegans models expressing human Aβ and tau proteins. Gene expression analyses examined transcription factors (DAF-16, skinhead [SKN]-1) and their targets (superoxide dismutase [SOD]-2, SOD-3, GST-4, and heat shock protein [HSP]-16.2). High-OL extract demonstrated superior AChE and COX-2 inhibition and antioxidant capacity. Low- and high-OL extracts reduced Aβ aggregation, ROS levels, and proteotoxicity via SKN-1/NRF-2 and DAF-16/FOXO pathways, whereas mid-OL showed moderate effects through proteostasis modulation. In tau models, low- and high-OL extracts mitigated mitochondrial ROS levels via SOD-2 but had limited effects on intracellular ROS levels. High-OL extract also increased GST-4 levels, whereas low and mid extracts enhanced GST-4 levels. OL extracts protect against AD-related proteinopathies by modulating oxidative stress, inflammation, and proteostasis. High-OL extract showed the most promise for nutraceutical development due to its robust phenolic profile and activation of key antioxidant pathways. Further research is needed to confirm long-term efficacy.
Jose M. Romero‐Marquez mail , María D. Navarro‐Hortal mail , Alfonso Varela‐López mail , Rubén Calderón Iglesias mail ruben.calderon@uneatlantico.es, Juan G. Puentes mail , Francesca Giampieri mail francesca.giampieri@uneatlantico.es, Maurizio Battino mail maurizio.battino@uneatlantico.es, Cristina Sánchez‐González mail , Jianbo Xiao mail , Roberto García‐Ruiz mail , Sebastián Sánchez mail , Tamara Y. Forbes‐Hernández mail , José L. Quiles mail jose.quiles@uneatlantico.es,
Romero‐Marquez
<a href="/17570/1/eFood%20-%202025%20-%20Navarro%E2%80%90Hortal%20-%20Effects%20of%20a%20Garlic%20Hydrophilic%20Extract%20Rich%20in%20Sulfur%20Compounds%20on%20Redox%20Biology%20and.pdf" class="ep_document_link"><img class="ep_doc_icon" alt="[img]" src="/style/images/fileicons/text.png" border="0"/></a>
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Garlic is a horticultural product highly valued for its culinary and medicinal attributes. The aim of this study was to evaluate the composition of a garlic hydrophilic extract as well as the influence on redox biology, Alzheimer's Disease (AD) markers and aging, using Caenorhabditis elegans as experimental model. The extract was rich in sulfur compounds, highlighting the presence of other compounds like phenolics, and the antioxidant property was corroborated. Regarding AD markers, the acetylcholinesterase inhibitory capacity was demonstrated in vitro. Although the extract did not modify the amyloid β-induced paralysis degree, it was able to improve, in a dose-dependent manner, some locomotive parameters affected by the hyperphosphorylated tau protein in C. elegans. It could be related to the effect found on GFP-transgenic stains, mainly regarding to the increase in the gene expression of HSP-16.2. Moreover, an initial investigation into the aging process revealed that the extract successfully inhibited the accumulation of intracellular and mitochondrial reactive oxygen species in aged worms. These results provide valuable insights into the multifaceted impact of garlic extract, particularly in the context of aging and neurodegenerative processes. This study lays a foundation for further research avenues exploring the intricate molecular mechanisms underlying garlic effects and its translation into potential therapeutic interventions for age-related neurodegenerative conditions.
María D. Navarro‐Hortal mail , Jose M. Romero‐Marquez mail , Johura Ansary mail , Cristina Montalbán‐Hernández mail , Alfonso Varela‐López mail , Francesca Giampieri mail francesca.giampieri@uneatlantico.es, Jianbo Xiao mail , Rubén Calderón Iglesias mail ruben.calderon@uneatlantico.es, Maurizio Battino mail maurizio.battino@uneatlantico.es, Cristina Sánchez‐González mail , Tamara Y. Forbes‐Hernández mail , José L. Quiles mail jose.quiles@uneatlantico.es,
Navarro‐Hortal
<a href="/17572/1/s12909-025-07070-5.pdf" class="ep_document_link"><img class="ep_doc_icon" alt="[img]" src="/style/images/fileicons/text.png" border="0"/></a>
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Background In recent years, medical education has increasingly embraced gamification as a method for teaching clinical skills. In Peru, social isolation resulting from the COVID-19 pandemic forced universities and academic institutions to restructure their teaching methods, while there are no reports about the impact of this strategies in Peruvian students. In this study we evaluated the feasibility and patterns of use of a novel video game based didactic activity in undergraduate students from a School of Medicine in Peru. Method We conducted a retrospective pilot study in medical students who used the Full Code Medical Simulation platform. We retrieved scoring data obtained from this platform for selected cases of clinical courses with an appropriate number of users [clinical medicine (CM) I (7 cases), CM II (17 cases), surgery I (6 cases) and surgery II (6 cases)]. cases)]. We also evaluated patterns of use and the association between academic performance and the Full Code scores. Results A total of 590 students were included in the study. We found a direct correlation between the student’s course grade and Full Code score in all courses (CM I: p < 0.001, CM II: p < 0.05, Surgery I: p < 0.05 and Surgery II: p < 0.05). CM II course students who dedicated more time to completing cases received better grades (p < 0.05). The pattern of use of Full code were similar in students regardless their academic performance. In addition, students with higher academic performance were more likely to have higher scores in the platform (p < 0.001). Conclusion The use of gamification in clinical simulation was highly feasible in students of medicine regardless their academic performance. Prospective and interventional studies are needed to assess if the Full Code platform directly affect the learning outcomes.
Maria Amalia Salafia mail , María Elena Perez-Ochoa mail ,
Salafia
<a class="ep_document_link" href="/17573/1/s41598-025-96332-9.pdf"><img class="ep_doc_icon" alt="[img]" src="/style/images/fileicons/text.png" border="0"/></a>
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Novel hybrid transfer neural network for wheat crop growth stages recognition using field images
Wheat is one of the world’s most widely cultivated cereal crops and is a primary food source for a significant portion of the population. Wheat goes through several distinct developmental phases, and accurately identifying these stages is essential for precision farming. Determining wheat growth stages accurately is crucial for increasing the efficiency of agricultural yield in wheat farming. Preliminary research identified obstacles in distinguishing between these stages, negatively impacting crop yields. To address this, this study introduces an innovative approach, MobDenNet, based on data collection and real-time wheat crop stage recognition. The data collection utilized a diverse image dataset covering seven growth phases ‘Crown Root’, ‘Tillering’, ‘Mid Vegetative’, ‘Booting’, ‘Heading’, ‘Anthesis’, and ‘Milking’, comprising 4496 images. The collected image dataset underwent rigorous preprocessing and advanced data augmentation to refine and minimize biases. This study employed deep and transfer learning models, including MobileNetV2, DenseNet-121, NASNet-Large, InceptionV3, and a convolutional neural network (CNN) for performance comparison. Experimental evaluations demonstrated that the transfer model MobileNetV2 achieved 95% accuracy, DenseNet-121 achieved 94% accuracy, NASNet-Large achieved 76% accuracy, InceptionV3 achieved 74% accuracy, and the CNN achieved 68% accuracy. The proposed novel hybrid approach, MobDenNet, that synergistically merges the architectures of MobileNetV2 and DenseNet-121 neural networks, yields highly accurate results with precision, recall, and an F1 score of 99%. We validated the robustness of the proposed approach using the k-fold cross-validation. The proposed research ensures the detection of growth stages with great promise for boosting agricultural productivity and management practices, empowering farmers to optimize resource distribution and make informed decisions.
Aisha Naseer mail , Madiha Amjad mail , Ali Raza mail , Kashif Munir mail , Aseel Smerat mail , Henry Fabian Gongora mail henry.gongora@uneatlantico.es, Carlos Eduardo Uc Ríos mail carlos.uc@unini.edu.mx, Imran Ashraf mail ,
Naseer
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Client engagement solution for post implementation issues in software industry using blockchain
In the rapidly advanced and evolving information technology industry, adequate client engagement plays a critical role as it is very important to understand the client’s concerns, and requirements, have the records, authorizations, and go-ahead of previously agreed requirements, and provide the feasible solution accordingly. Previously multiple solutions have been proposed to enhance the efficiency of client engagement, but they lack traceability, trust, transparency, and conflict in agreements of previous contracts. Due to the lack of these shortcomings, the client requirement is getting delayed which is causing client escalations, integrity issues, project failure, and penalties. In this study, we proposed the UniferCollab framework to overcome the issues of collaboration between various teams, transparency, the record of client authorizations, and the go-ahead on previous developments by implementing blockchain technology. We store the data on the permissible network in the proposed approach. It allows us to compile all the requirements and information shared by clients on permissible blockchain to secure a large amount of data which enhances the traceability of all the requirements. All the authorizations from the client generate push notifications for any changes in their current system executed through smart contracts. It removes the ambiguity between various development teams if the client has only shared the requirement with one team. The data is stored in the decentralized network from where information is gathered which resolves the traceability, transparency, and trust issues. Lastly, evaluations involved a total of 800 hypertext transfer protocol (HTTP) requests tested using Postman with blockchain block sizes ranging from 0.568 KB to 550 KB and an average size increase of 280 KB was observed as new blocks were added. The longest chain in the network was observed during 800 repetitions of blockchain operations. Latency analysis revealed that delays in processing HTTP requests were influenced by decentralized node processing, local machine response times, and internet bandwidth through various experiments. Results show that the proposed framework resolves all client engagement issues in implementation between all stakeholders which enhances trust, and transparency improves client experience and helps us manage disputes effectively.
Muhammad Shoaib Farooq mail , Khurram Irshad mail , Danish Riaz mail , Nagwan Abdel Samee mail , Ernesto Bautista Thompson mail ernesto.bautista@unini.edu.mx, Daniel Gavilanes Aray mail daniel.gavilanes@uneatlantico.es, Imran Ashraf mail ,
Farooq